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Articles by Pan Zhang
Total Records ( 4 ) for Pan Zhang
  Hua Tang , Xin Sheng Liu , Yu Zhen Fang , Li Pan , Zhong Wang Zhang , Peng Zhou , Jian Liang Lv , Shou Tian Jiang , Wen Fa Hu , Pan Zhang , Yong Lu Wang and Yong Guang Zhang
  In recent years, as the genome sequencing technology and protein peptide chemical synthesis technology become mature, especially the proposal of epitopic biology, more and more Foot-and- mouth Disease Virus (FMDV) antigenic epitopes are revealed. Studies on epitopes have greatly promoted the development of new-type vaccines since the early 1980s. Thanks to the consecutive discovery of new epitopes, people can overcome the Major Histocompatibility Complex (MHC) restriction between species more easily. Researchers could also produce poly-vaccine containing epitopes of different serotypes. The selected epitope sequences are highly conserved in different serotypes and this is the key guarantee of cross immune response of vaccine. It is obvious that epitope will play a key role in elaborating new-type FMDV vaccines. This study summarized the epitopes of FMDV.
  Hua Tang , Xin-Sheng Liu , Yu-Zhen Fang , Li Pan , Zhong-Wang Zhang , Peng Zhou , Jian-Liang Lv , Shou-Tian Jiang , Wen-Fa Hu , Pan Zhang , Yong-Lu Wang and Yong-Guang Zhang
  The Foot-and-mouth Disease (FMD), which is the most devastating disease of livestock husbandry, drastically hinders the development of stock raising. At present the main FMD vaccine is still traditional inactivated vaccine, as its good performance in protective activity and immune efficacy, it is widely used in the world for preventing and controlling this disease, especially in developing countries. However, people have realized many disadvantages of inactivated vaccine. In order to resolve these problems, the scientists are conducting some new research about novel FMD vaccine to seek for more secure and effective vaccines. Nowadays, with the rapid development of molecular biology, researchers are paying high emphasis on novel FMD vaccines, such as, synthetic peptide vaccine, epitope-based vaccine, DNA vaccine, chimeric vaccine and so on. There is no doubt that these new-type FMD vaccines will make great contribution to the prevention and control of FMD. This study reviewed the international research progress on the traditional vaccines and novel vaccines of FMD.
  Hua Tang , Xin-Sheng Liu , Yu-Zhen Fang , Li Pan , Zhong-Wang Zhang , Peng Zhou , Jian-Liang Lv , Shou-Tian Jiang , Wen-Fa Hu , Pan Zhang , Yong-Guang Zhang and Yong-Lu Wang
  The Z-curve is a geometrical tool for visualizing and comparing genomes. Since, the curve contains the information carried by the given sequence, DNA sequences could be analyzed systematically. In this study, the ORF5 gene of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) was analyzed by the Z-curve method and the DNAstar (DNASTAR Inc.) computer programs. The results revealed by these two methods were identical. The phylogenetic tree is more digitized and the Z-curve method is more picturesque. It turned out to be that, the Z-curve method shows a widely application prospect in phylogenetic relationships analysis. However, the Z-curve method is still in its premature stage. Novel algorithms are expected to be exploited to extract more information involved in the Z-curves.
  Pan Zhang and Jianlong Wang
  This study was conducted to test the immunostimulatory effect of graded dose of alanine supplementation on inactivated vaccine immunized mice. Animals were randomly divided into five groups: mice were immunized with inactivated vaccines, mice were treated with dietary 0.5% alanine supplementation and immunized with inactivated vaccines, mice were treated with dietary 1.0% alanine supplementation and immunized with inactivated vaccines, mice were treated with dietary 2.0% alanine supplementation and immunized with inactivated vaccines and all the mice immunized with PBS. Results found that alanine supplementation has little significant effect on serum antibody production, serum interleukin-1 beta and 8 levels and survival rate of mice after challenge. However, higher dose of alanine supplementation increased serum GSH-PX activity compared to the lower dose of alanine supplementation. Collectively, dietary alanine supplementation has little effect on the immune parameters in vaccine immunized mice indicating alanine can be used as isonitrogenous control to study the immune regulatory function of other amino acids.
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