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Articles by P.I. Jewo
Total Records ( 4 ) for P.I. Jewo
  L.C. Saalu , A.A. Osinubi , P.I. Jewo , A.O. Oyewopo and G.O. Ajayi
  The therapeutic value of Doxorubicin (DOX) as anticancer antibiotic is limited by its organotoxicity. It has been shown that free radicals are involved in doxorubicin-induced toxicity. Doxorubicin causes the generation of free radicals and the induction of oxidative stress, associated with cellular injury. Because of the great importance of DOX in cancer therapy, researchers have expended great efforts trying to prevent or attenuate the side effects of DOX administration. There has, however, been only a little success in this regard. In this study the ameliorating role of antioxidant-rich ethanolic seed extract of Citrus paradisi (CP) on DOX-induced testicular oxidative stress and impaired sperm parameters was investigated. Three experimental groups of Wistar rats were used; CP-alone group that received orally CP 10 mg kg-1 b.wt. daily for 14 days followed by intraperitoneal (i.p.) Normal Saline (NS) 2.5 mg kg-1 b.wt. DOX-alone group that had ip DOX 10 mg kg-1 b.wt. as a single dose. CP plus DOX-group that were similarly given DOX, but also had oral CP 10 mg kg-1 b.wt. pretreatment for 14 days. There was also a corresponding control group. The animals were autopsied 8 weeks after DOX or NS injections. Results showed that DOX-induced reduction in sperm motility and epididymal sperm concentrations as well as increase in total abnormal sperm rates were all normalized in the group pretreated with CP. Pretreatment with CP ameliorated the testicular content of Glutathione (GSH) and Auperoxide Dismutase (SOD), Catalase (CAT) and Glutathione Peroxidase (GPx) activities. Similarly, CP treatment attenuated the DOX-induced increase in testicular lipid peroxidation reflected by malondialdehyde (MDA) levels. These data indicate that CP protects the rat testis against DOX-induced oxidative stress and deranged sperm characteristics.
  L.C. Saalu , P.I. Jewo , I.O. Fadeyibi and S.O. Ikuerowo
  Experimental animal models have been extensively used to assess the effect of unilateral varicocele on ipsilateral testicular histology and function. There is therefore an enormous body of evidence on the detrimental effects of varicocele on the affected testis. A vacuum however still exists in our knowledge of the effects of unilateral varicocele on the contralateral testicular morphology and function. The present study evaluated the effect of left unilateral varicocele on the right testicular anatomy and physiology in Sgrague-Dawley rats (Rattus norvegicus). Fifty five immature rats were divided into two groups (group A, 45 rats and group B, 10 rats). Group A rats were rendered experimentally varicocelized by the complete ligation of their left main spermatic veins. Group B rats were sham operated to serve as control. Sixteen weeks after varicocele induction, bilateral testicular weight, bilateral testicular volume, bilateral caudal epididymal sperm characteristics, bilateral testicular histomorphometry and fertilizing capacity were all tested. The results show that left testicular weight and volume were significantly lower (p<0.05) than the right testicular weight and volume in varicocelized rats. The right testicular weights and volumes in varicocele rats were however also significantly lower (p<0.05) compared to the testicular weights and volumes of the control group. Further the sperm content and percentage motility were significantly lower (p<0.05) in the left epididymides than the right epididymides of the varicocele rats. However, the caudal epididymal sperm concentration and percentage sperm motility were significantly lower (p<0.05) bilaterally in the varicocele group compared to the control rats. Histomorphological profiles of the groups of animals parallel the sperm parameter findings. Present results indicate a bilateral derangement of testicular morphology and function with unilateral varicocele.
  L.C. Saalu , P.I. Jewo , O.E. Yama and J.A. Oguntola
  Hydroxyurea (HDU) is approved for reducing the frequency of painful crises and the need for blood transfusions in adults with sickle cell disease who experience recurrent moderate to severe pain. Treatment with HDU is however, associated with known side effects such as cytotoxicity and myelosuppression. In the present study we evaluated the effect of a clinically relevant dose of HDU used in the treatment in sickle cell disease on the seminiferous tubules of rats. Adult male Sprague -Dawley rats were orally treated with 25 mg HDU kg-1 body weight/day for 28 consecutive days. Control rats received the vehicle for HDU which was normal saline 2.5 mL kg-1 body weight. Groups of rats were sacrificed variously on the next day, the 56th and the 112 day after the last dosing with HDU or saline. The testis were recovered, weighed and subjected to histopathology. The gross anatomical parameters assessed included the testicular weights and volumes while stereological parameters estimated includes diameter and cross-sectional area of the seminiferous tubules; number of profiles per unit area and numerical density of seminiferous tubules. The results show that treatment with HDU exhibited significant atrophic degeneration in the seminiferous tubules compared with controls. There was an initial manifestation of progressive worsening of the testicular profiles with passage of time, as the animals sacrificed on day 56 demonstrated greater toxicity than those autopsied a day after day 28. However, the animals sacrificed on day 112 showed some improvement in their testicular profiles, suggesting some degree of self-reversal or recovery of the effect. We conclude that HDU has a deleterious effect on the rat testis even at the clinically relevant dose used in management of sickle cell disease.
  I.O. Fadeyibi , L.C. Saalu , P.I. Jewo , A.S. Benebo and S.A. Ademiluyi
  The aim of this study is to investigate the histopathological features of the testis of Burns patients where the burns did not involve the perineum. The present study is a case series report of the testicular histopathological changes of adult patients that died from major burns not involving the perineum. All adult male patients that sustained major burns, were managed at Lagos State University Teaching Hospital (LASUTH) and satisfied the inclusion criteria were recruited into the study. Testicular specimens were obtained during the routine postmortem examinations of patients that died from burns. Histological evaluation of the testes was done by light microscopy. There was mild to moderate testicular interstitial oedema with markedly reduced Leydig and Sertoli cells. Cells of the Spermatogenic series were present and of normal appearances. However, cells of the Spermiogenic series were scanty and no mature spermatozoon was observed. These findings show that major burns result in indirect derangement in the testicular morphology.
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