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| Articles
by
P. Chinnaswamy |
Total Records (
4 ) for
P. Chinnaswamy |
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P. Uma Devi
and
P. Chinnaswamy
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The aim of the present study was to estimate the effect of age and gender
on the levels of primary and secondary antioxidants and Malondialdehyde
in red blood cells of the selected Schizophrenia patients. In our present
study, the activities of six free radical scavenging enzymes (super oxide
dismutase (SOD), catalase (CAT)), glutathione peroxidase (GSH-Px), glutathione
Transferase (GST), glucose-6-phosphate dehydrogenase (G6PD), Caeruloplasmin
ferroxidase (Cp) and the level of thiobarbituric acid-reactive substances
(TBARS) as an index of lipid per oxidation were analyzed in the different
age groups of schizophrenia patients. Role of gender was also analyzed
in both schizophrenia and control subjects. It was observed from the results
that there was a significant increase in erythrocyte MDA levels and activity
of SOD and a significant decrease in erythrocyte CAT,GSH- Px, Cp-ferroxidase
and G6PD levels in patients with schizophrenia, when compared to controls
(p<0.01). The results have also shown that among different age groups,
highly significant oxygen free radical production, evidenced by increased
levels of MDA and decreased levels of antioxidant enzymes activity was
found in adult and elderly schizophrenia patients, which supports the
more pronounced oxidative stress in adult and elderly schizophrenia patients
when compared to young schizophrenia patients. The statistically more
significant increase (p<0.001) in the activity of SOD in elderly schizophrenia
subjects may be a compensatory regulation in response to increased oxidative
stress in elders. The decreased concentrations of the CAT, GSH-Px, G6PD
and Cp-ferroxidase support the hypothesis that lipid per oxidation is
an important causative factor in the pathogenesis of schizophrenia. These
data reveal that antioxidant defense mechanisms might be impaired a lot
in normal elderly people and schizophrenia patients with age group above
30 (i.e., adults and elders). As for as gender concerned, we observed
a significant raise in the levels MDA, SOD and significant decrease in
the levels of selected antioxidant enzymes in schizophrenia male and female
subjects when compared with the respective control male and female subjects
(p<0.01). But we found statistically more significant increase in the
levels of MDA and highly significant decrease in the levels of the secondary
antioxidant enzymes G6PD and Cp ferroxidase (p<0.001) were found in
schizophrenia males when compared with schizophrenia females. Supplementation
of antioxidants may prevent further oxidative injury in elderly schizophrenia
patients. |
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M. Sathya
and
P. Chinnaswamy
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Bladder cancer is the one of the most common genito urinary tract malignancy and
more than 90% of bladder cancer is of urothelial carcinomas that ranks fourth
among cancers occurring in males. Although, over 50% of cases are diagnosed
by biopsy at an early stage. The prognosis is sometimes difficult to assess
because of heterogeneity, multifocality and tumor recurrence. In the present
study, among 70 urinary bladder tumor patients, 61 (87%) were of Transitional Cell
Carcinoma (TCC) and 9 (13%) of adenocarcinoma. Similarly, in the observed TCC
patients, high grade is observed in 44 cases (63%) whereas low grade was in
17 cases (24%). The study also revealed among the TCC, 18 (25%) patients have
shown the muscle invasion, 61 (87%) with lamina propria invasion and 18 (25%)
patients with lymph vascular space invasion. |
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P. Uma Devi
,
S. Murugan
,
S. Suja
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S. Selvi
,
P. Chinnaswamy
and
E. Vijayanand
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The aim of this study is to evaluate the antibacterial
efficacy of Achyranthes bidentata against seven different microorganisms
such as Escherichia coli, Bacillus subtilin, Proteus vulgaris,
Salmonella typhi, Staphylococcus aureus, Pseudomonas species and
Klebsiella pneumoniae. The values of zone of inhibition were measured and
compared with standard values. All the extracts of root, stem, leaves and
flowers showed high sensitive to Proteus, Escherichia coli,
Bacillus subtilin, Salmonella typhi, Klebsiella pneumoniae, moderate and
less sensitivity to Staphylococcus aureus and Pseudomonas species. The
antiperoxidative effect of various parts of Achyranthes bidentata was also
done. Goat liver was used as the lipid source. This in vitro
evaluation was done by the measurement of thiobarbituric acid reactive
substances (TBARS) in the experimental mixtures of tissue homogenates. The
results suggest that the ethanolic extracts of Achyranthes bidentata root
and flowers possessed significant in vitro lipid peroxidation
inhibiting activities, which is possibly attributed to its free radical
scavenging properties. All the parts of plant extracts were subjected to
qualitative analysis to find out phytoconstituents present in them.
Results showed the presence of alkaloids, flavonoids, phenols, and
steroids and the absence of saponins, glycosides and tannins. |
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S. Selvi
,
P. Uma Devi
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S. Suja
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S. Murugan
and
P. Chinnaswamy
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The modulation of the mushroom used now-a-days in the
field of medicine, is the way where this is partly achieved. Among these,
the `antioxidants` which are capable of deactivating the free radicals
follow either enzymatic or non-enzymatic pathways. The aim of this project
is to incorporate the non-enzymatic antioxidant in fresh and dried form of
powered samples of the oyster mushroom (P. leurotus florida) and
milky mushroom (Calocybe indica). This study revealed the presence
of non-enzymatic antioxidant in the selected samples and the striking
feature of this work is to maximize the usage of mushrooms in the powdered
form when there is certain unstable conditions for the usage of mushroom
in the fresh form. |
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