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This study aims to measure Total Antioxidant Capacity (TAC) and
Total Peroxides (TP) in schizophrenia patients with positive, negative
and cognitive symptoms using Ferric Reducing Activity of Plasma (FRAP)
and evaluate its relations with oxidative stress. We measured the plasma
total antioxidant potential and total peroxides in 60 schizophrenia patients
and in 60 well-matched non-schizophrenic control subjects. The association
between the total antioxidative-oxidative potential and the symptoms,
severity of schizophrenia were studied. Total antioxidant capacity/total
peroxide of the clinical samples was measured using latest spectrophotometric
measurement method. Results showed that plasma TAC was found to be lower
in patients with schizophrenia than those of controls. On the contrary,
the patients had high total plasma peroxide levels. Oxidative Stress Index
(OSI) values of the patients were significantly higher than those of controls
(p<0.001). Plasma TAC of each schizophrenia symptoms were significantly
lower than healthy controls (p<0.01 for patients with negative and
cognitive symptoms and p<0.001 for patients with positive symptoms).
When intragroup comparisons were performed, patients with positive symptoms
had significantly very low plasma TAC levels (p<0.001) compared to
other negative (p<0.01) and cognitive subtypes (p<0.01). Plasma
TAC in schizophrenia patients was significantly and inversely correlated
with symptom severity. This study indicates that schizophrenia is associated
with increased oxidative stress, depleted antioxidant status in schizophrenia
subjects and supplementation with more antioxidative supplements could
be considered in treatment.
