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Articles by Oyelola B. Oloyede
Total Records ( 2 ) for Oyelola B. Oloyede
  Musa O. Salawu , Oyelola B. Oloyede , Adenike T. Oladiji , Nasiru O. Muhammad and Musa T. Yakubu
  Context: Archachatina marginata Swainson (Achatinidae) is found in Nigeria, West Africa. Its hemolymph is applied as a disinfectant to blades and fresh cuts of circumcision in Yorubaland. The hemolymph is also used in traditional medicine practice. Investigation into its anti-endotoxin response is being studied for the first time. Objective: This study determined whether endotoxin causes measurable and concentration-dependent protein coagulation in the separate hemolymph fractions and in hemocyte lysate (HL)/plasma mixtures. Materials and methods: Endotoxin was prepared by inoculating 5% w/v dextrose with locally isolated Escherichia coli cells and incubated for 48 h before sterilization. Pyrogenicity was determined by rabbit test method and use the of LAL kit. Hemolymph fractions were exposed to endotoxin while controls were exposed to endotoxin-free water (0.025 EU/ml). HL/plasma (1:1 v/v) was exposed to varied endotoxin concentrations. Results: Data indicated significantly higher protein coagulates induced by endotoxin in all the hemolymph fractions (P < 0.05). Maximum protein coagulation in mixture of HL/plasma 1:1 was recorded. Exposure of HL/plasma at optimal ratio to varied endotoxin caused linear protein coagulation up to 1.0 EU/ml, beyond which it dropped significantly and unresponsive to further increase in endotoxin doses. Discussion and conclusion: There was endotoxin-induced protein coagulation, which is endotoxin concentration-dependent. The optimal coagulation observed for 1:1 HL/plasma mixture suggests stronger interaction between the hemocytes and the plasma in response to endotoxin. There are LPS-binding proteins in the plasma and hemocytes of A. marginata. This finding may be employed in detection and quantification of endotoxin in future.
  Taofik O. Sunmonu , Olufemi D. Owolabi and Oyelola B. Oloyede
  The impact of short term exposure to waterborne anthracene on the activities of Gamma Glutamyl Transferase (GGT), Alanine aminotransferase (ALT) and Alkaline aminotransferase (ALP) in the liver and stomach mucosa of juvenile African catfish, Heterobranchus bidorsalis Geoffroy Saint Hilaire, 1809 was investigated. Fish specimens weighing 73.00±2.50 g (n = 72) were grouped into six of twelve fishes each in 30 L aquarium. Each group was exposed to different concentrations (0 (control), 0.25, 0.50. 0.75, 1.00 and 1.25 g L-1) of anthracene for 54 h. The results showed that there was a significant (p<0.05) inhibition of all the enzymes’ (GGT, ALT, ALP) activities in both the liver and stomach of H. bidorsalis in relation to the control. Inhibition of each enzyme increased with increase in concentration of anthracene, with the highest inhibition of 79.96% (GGT), 89.74% (ALT) and 46.26% (ALP) and lowest inhibition of 13.98% (GGT), 22.80% (ALT) and 31.44% (ALP) recorded at the concentration of 1.25 and 0.25 g L-1, respectively. The decrease in the activities of the enzymes could be due to their possible leakage into general blood circulation or could be as a result of organ dysfunction, thus indicating that anthracene could induce oxidative stress on H. bidorsalis. Percentage mortality ranged between 0 and 44.44%, with the highest mortality recorded at the highest tested concentration of anthracene. The results suggest that GGT, ALT and ALP can be used as potential environmental biomarkers for anthracene-induced hepatotoxicity and gastrotoxicity in H. bidorsalis.
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