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Articles by O.S. Akinsomisoye
Total Records ( 8 ) for O.S. Akinsomisoye
  Y. Raji , S.O. Ifabunmi , O.S. Akinsomisoye , A.O. Morakinyo and A.K. Oloyo
  This work was undertaken to investigate the individual effects and probable mechanism of action of chlorpromazine hydrochloride (largactil) and thioridazine hydrochloride (melleril) on male reproductive functions, in albino rats. A total of 45 adult male albino Wistar-strain rats were used. Five rats served as the control while the remaining forty rats were divided into four groups, of 10 rats each. Rats in group I were treated with 2.3 mg kg-1 BW, while those of group II received 5.7 mg kg-1 BW of chlorpromazine. Rats in group III, were treated with 1.7 mg kg-1 BW, while those of group IV received 2.3 mg kg-1 BW of thioridazine. Control rats received vehicle of the drugs (i.e. distilled water). Drugs and vehicle were administered orally on a daily basis. Five rats, in each of the four drug-treated groups served as the recovery rats. Sperm characteristics evaluation, serum levels of testosterone and histopathological alterations in the testis were assessed both after four weeks of continuous drug administrations and four weeks of drug withdrawal. Chlorpromazine and thioridazine significantly caused a reduction in the absolute weights of the testis, epididymis and seminal vesicles (p<0.01) at high and low doses. Weight of the prostate gland was also reduced significantly (p<0.05) at the high dose. The epididymal sperm motility, viability (life/death ratio) and counts were significantly reduced (p<0.01) at high dose of chlorpromazine and thioridazine. Moreover, sperm morphological abnormalities were significantly increased (p<0.01) at both doses of the drugs. Reduction in serum levels of testosterone for both drugs was statistically significant (p<0.01). The histopathological alterations observed in the testis includes moderate to severe degeneration of seminiferous tubular epithelium. Fertility and other associated changes were restored within four weeks of cessation of treatment. Chlorpromazine and thioridazine appear to have reversible antifertility actions in male albino rats. These actions were probably mediated within the testis and epididymis.
  Y. Raji , M.A Gbadegesin , O.A Osonuga , Rahmat A. Adisa , O.S. Akinsomisoye , F.O Awobajo , Olufadekemi T. Kunle-Alabi , P.R.C. Esegbue Peters , I.O Osonuga and A.F. Lamidi
  Aqueous extract of Spondias mombin in different dilutions was employed to assess its impact on male reproductive, haematologic and biochemical indices of male albino rats. A single daily intragastric administration of 8.4, 16.8 and 33.6 mg kg-1 b.w day-1 of the extract for four weeks did not cause any adverse effect on body and organ weights except the weight of the liver that showed a slight increase. There was a marked dose-dependent reduction (p<0.05) in epididymal sperm progressive motility, sperm count, viability (live/dead ratio) and a dose-dependent increase (p<0.05) in percentage abnormal spermatozoa. Abnormalities like double heads, double tails, detached heads and broken tails were frequently observed. Epididymal α-glucosidase activity was significantly reduced (p<0.05). However, prostatic acid phosphatase activity and citric acid levels and seminal fructose concentrations remained unchanged following Spondias mombin treatment. Blood analysis showed that red cell and white cell counts and haematocrit (Hct) levels were in the normal range. Bilirubin, serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), urea and protein concentrations were slightly altered by the extract of Spondias mombin. Discontinuation of the extract resulted in full recovery within four weeks of treatment cessation. The results suggest that aqueous extract of the bark of Spondias mombin has reversible antifertility action, the testis and the epididymis probably being the prime sites of action.
  Y. Raji , A.O. Morakinyo , O.S. Akinsomisoye , A.K. Oloyo , P.R.C. Esegbue-Peters and Olufadekemi T. Kunle-Alabi
  This study was carried out to investigate the impact of oral administration of chloroform extract of Carica papaya seed (CPE) on implantation and pregnancy in female albino rats. The study was divided into three experimental sections. Each section was subdivided into 4 groups treated, respectively with 25, 50 and 100 mg kg 1 b.w CPE and 2.5% tween 80 in normal saline (vehicle for CPE; control). Rats in section 1 were treated with CPE for two weeks before mating (pre-coital). Rats in section 2 were administered CPE from day 1 of pregnancy till term (post coital) while rats in section 3 received the extract for two weeks before mating and thereafter throughout term (pre and post-coital). Implantation sites and resorptions were determined in some of the pregnant rats after laparotomy. The gestation period, litter size and fetal weight were recorded in the remaining rats. The litters were also observed for any morphological alterations. The extract treated rats had significant decreases in litter size and implantation count (p<0.01). The percentage resorptions increased in a dose dependent manner while the fetal weight and morphology remain unchanged when compared with the normal untreated control groups. The percentage resorptions were high in CPE treated rats when compared with the control group. None of the 100 mg kg 1 b.w CPE treated female rats had litters. The results suggest that the chloroform extract of Carica papaya seed has anti-implantation and abortifacient properties in female albino rats.

  Y. Raji , I.O. Osonuga , O.S. Akinsomisoye , O.A. Osonuga and O.O. Mewoyeka
  Male Wister albino rats were exposed to artemether by gavage at dosages of 25, 50 and 75 mg kg-1 day-1 for 1, 2 and 3 days. The control groups received sterile water (control 1) and 5% ethanol (vehicle for artemether, control 2). The maximum volume injected in all groups was 0.5 mL. Rats administered the highest dose for three days were mated with female rats to determine the fertilizing capacity of their epididymal sperms and fertility status. Artemether significantly reduced (p<0.05) the progressive sperm motility, viability, sperm count and serum testosterone levels in dose and duration dependent manners, factors that may impair fertility. None of the untreated cohabited female rats got pregnant throughout the period of the study. These changes were restored in recovery experiments. The results suggest that artemether could induce reversible infertility in rats.
  O.A. Osonuga , I.O. Osonuga , O.S. Akinsomisoye , Y. Raji and O.G. Ademowo
  Efforts in this study were directed at comparing changes in Packed Cell Volume (PCV) in the cause of treatment of severe malaria patients with artemether and quinine in Ikenne Local Government area of Ogun State, Southwest, Nigeria. Thirty two patients in the study were randomly assigned to receive either artemether or quinine under medical supervision. 16 patients were allocated into two treatment groups. Patients in the quinine group received quinine 10 mg kg-1 in 5% dextrose-saline infusion intravenously at 8 h intervals but changed to oral quinine ( 10 mg kg-1 b.w; 8 h intervals) for 7 days . The patients in the artemether group received 1.6 mg kg-1 artemether twice at day 0 and then 1.6 mg kg-1 daily for the next four days through deep intramuscular route. The patients were then followed up for 14 days. The results this study showed that the PCV of the patients was 25.9% (range of 14-41%) at day 0. The mean PCV of the patients was 26.25% and 25.56% following quinine and artemether treatments, respectively. The mean PCV at day 14 was 34.5 and 38.2%, respectively for quinine and artemether. The results from this study indicate that artemether relative to quinine has a faster and sustained recovery from malaria induced anaemia.
  Y. Raji , O.A. Osonuga , O.I Shittu , O.S. Akinsomisoye , V.A. Togun and Mistura O. Azeez
  A study of 542 randomly selected female students of the University of Ibadan and Ladoke Akintola University, Ogbomoso, both located in the southwestern Nigeria was carried out to determine the current menarcheal age and predicting factors influencing its onset. Mean age at menarche was found to be 13.66±1.82 years. 49.3% attained menarche between the ages of 13 and 14 years, 75.7% between 12 and 15 years, 8.1% at 16 while 6.1% had their first menstruation at age 11 years. There was a significant linear relationship (p = 0.004) between the age at menarche and body weight. The body surface area and height showed an insignificant inverse relationship with age at menarche. Socio-economic status of the parents had no influence on the age at menarche. Simple and multiple regression models for predicting age at menarche were derived from body weight, height and body surface area.
  Y. Raji , O.A Osonuga , S.B Olaleye , K.I. Adedokun , O.S. Akinsomisoye and O.O Mewoyeka
  Comparative reproductive activities of chloroquine, mefloquine and sulphadoxine-pyrimethamine were explored in albino Wistar rats and semen from West African Dwarf Buck (WADB) with a view to elucidating the mechanism of action of these drugs on malereproduction. Five adult male rats were administered 0.5 mL distilled water and served as the control. Five rats each were administered orally chloroquine (10 mg kg -1 b.w.), mefloquine (10 mg kg -1 b.w.) and sulphadoxine-pyrimethamine (5 mg kg -1 b.w.) orally, for four weeks. Each group had it`s own recovery group. Sperm counts, motility and morphology were reduced in rats treated with these drugs in the order mefloquine (p<0.05)> chloroquine > sulphadoxine-pyrimethamine. There was an appreciable recovery in the motility of sperms in all recovery groups. Semen samples from WADB were extended separately with chloroquine, mefloquine and sulphadoxine-pyrimethamine. Extender 1 (first control) had no PENSTRIP (Penicillin and Streptomycin combination) while extender 2 (standard extender; second control) had PENSTRIP. Semen in extenders 3, 4 and 5 were treated with chloroquine, mefloquine and sulphadoxine-pyrimethamine, respectively. Spermatozoa progressive motility in these extenders examined under the microscope at 24 h for 5 days significantly reduced in mefloquine (p<0.01), slightly with chloroquine and unchanged with sulphadoxine-pyrimethamine. The pH of the extenders was significantly reduced in duration dependent manner in mefloquine while it remained unchanged with chloroquine and sulphadoxine-pyrimethamine. The results suggest the safety of sulphadoxine-pyrimethamine and chloroquine in preservation of semen ex vivo while the negative impact of mefloquine could reside within the testis or epididymis.
  Y. Raji , A.O. Morakinyo , A.K. Oloyo , O.S. Akinsomisoye , Olufadekemi , T. Kunle-Alabi , P.R.C. Esegbue-Peters and F.O. Awobajo
  The impact of oral administration of 100 mg kg 1 b.w of chloroform extract of Carica papaya seed (CPE) on oestrous cycle, fertility and serum 17 -oestradiol levels, in female rats was investigated. Ten proestrous rats received 2.5% tween 80 in normal saline (vehicle for CPE) and served as the control in each part of the study. In the oestrous cycle study, ten proestrous rats were treated with CPE for 14 days. The phases and frequencies of the oestrous cycles of the rats were determined daily for another 14 days while CPE treatment continued. In the fertility study, ten proestrous rats were treated as in the oestrous cycle study for 14 days and were thereafter cohabited with fertile untreated male rats for another 14 days while CPE treatment lasted. CPE did not adversely affect body weight of the rats. However there was a significant decrease (p<0.05) in the weight of the ovary, but not in the uterus. There was a significant decrease (p<0.01) in serum 17 -oestradiol levels in CPE treated rats. The oestrous cycle became irregular, with prolonged diestrous phase from the 3rd week of CPE treatment. There were disorganization and degeneration in the ovary. The uterus showed signs of vacuolation and mild disorganization. The extract treated rats produced a significant decrease in litter number (p<0.01) but the fetal weight and morphology remain unchanged relative to the control. The results suggest that chloroform extract of Carica papaya seed has antifertility properties, possibly acting via inhibition of oestrogen secretion.
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