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Articles by O.C. Ugbogu
Total Records ( 3 ) for O.C. Ugbogu
  N.A. Obasi , E.I. Akubugwo , O.C. Ugbogu and Glory Otuchristian
  Physico-chemical parameters (pH, EC, %moisture, CEC, TOC, TOM, total nitrogen, %PO43¯, SO42¯) and the chemical fractionation, mobility and bioavailability of heavy metals (Cd, Cu, Mn, Pb, Zn, Fe, Ni and Cr) in refuse waste soils of some dumpsites along Enugu-port Harcourt Expressways, South-East, Nigeria were investigated and compared with control soils from the same terrain using standard analytical methods. Results showed significant (p>0.05) higher changes in the soil physico-chemical properties relative to the controls, thus implicating the waste soils to be more fertile. Also, mean of total extractable metals in the samples analyzed for Cd, Cu, Mn, Pb, Zn, Fe, Ni and Cr ranged from 23.41-107.18, 10.58-238.50, 141.21-442.03, 35.11-635.31, 186.38-505.57, 76.46-371.73, 13.00-221.97 and 13.55-26.77 mg kg-1 dry weight, respectively. Cd followed by Fe and then Pb were mostly found to be in the mobile phase of the samples indicating that the metals were potentially more bio-available to the environment than the other metals studied. Overall, the order of mobility and bioavailability of the metals is Cd>Fe>Pb>Mn>Zn>Cr>Ni>Cu. The implications of these results towards the understanding of the underlying causes of plants species diversity changes and growth, bioaccumulation and bio-toxicity of some edible plants on dumpsites were discussed.
  O.C. Ugbogu , V.O. Nwaugo , A. Orji and N. Ihuoma
  The antimicrobial spectrum of quinolones namely ceporex, ciprofloxacin, tarivid, peflacine and nalidixic acid on Staphylococcus aureus isolated from hospital patients in Okigwe was studied. Out of 79 samples examined Staphylococcus aureus was isolated from 50(71.42%). Out of 17 urethral swab isolates 15(88.27%), 10(58.8%), 12(70.5%), 8(47.05%) and 8(47.05%) were resistant to ceporex, ciprofloxacin, tarivid, peflacine and nalidixic acid, respectively. The percentage of the of the S. aureus isolates resistant to each quinolone was 62, 64, 74, 44 and 88% for ceporex, ciprofloxacin tarivid, peflacine and nalidixic acid, respectively. Isolates from urine, semen and vagina were less resistant to the quinolones.
  E.S. Amadi , A. Oyeka , R.A. Onyeagba , I. Okoli and O.C. Ugbogu
  The antimicrobial effect of cold water, hot water and ethanolic extracts of Spondias mombin and Baphia nittida on cariogenic streptococci isolated from dental caries patients attending the Ebonyi State University Teaching hospital dental clinic Abakaliki was investigated using the agar well diffusion technique. The cold water and ethanolic extracts of Baphia nittida showed inhibition zone diameter (IZD) of 10 and 12 mm respectively at 400 mg mL -1, while the hot water showed no inhibitory effect. All extracts of Spondias mombin did not inhibit the test organism. The cold water and ethanolic extracts of Baphia nittida showed Minimum Inhibitory Concentration (MIC) of 100 and 50 mg mL -1 respectively. The combination of the cold water extracts of the two herbs showed enhanced activity of 13 mm. Phytochemical analysis of Baphia nittida revealed the presence of flavonoids, glycosides, proteins saponins, tannins, carbohydrate and steroidal aglycone. Acute toxicity testing of Baphia nittida at a range of 250-5000 mg kg -1 bw using mice showed no clinical signs of acute toxicity. No chemical toxicity was observed amongst rats given Baphia nittida extracts 500 and 1000 mg kg -1 bw after 30 days. Baphia nittida may be a potential source of an antimicrobial agent for the treatment and management of dental caries.
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