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Articles by Noraznawati Ismail
Total Records ( 2 ) for Noraznawati Ismail
  Ibrahim M.S. Eldeen , Jochen Ringe and Noraznawati Ismail
  Background and Objective: Bruguiera cylindrica is a mangrove tree species. It has various medicinal uses including usage for, lower blood pressure, bleeding, hemorrhage and ulcers. This study aimed to investigate the anti-inflammatory and anti-rheumatoid arthritis effects of the plant. Materials and Methods: Extracts obtained from the leaves and roots of the plant were evaluated for their inhibitory effects against the enzymes: Cyclooxygenase-2, 5-Lipoxygenase and Acetylcholinesterase using the in vitro bioassay models. The GC-MS was used to determine the major active constituents. Synovial fibroblast cells were induced using TNF-α and IL-1 β and MTT cell viability assay was used to determine the cell viability of both, the normal and the induced cells. Results: The DCM leave extract showed the highest inhibitory effects against the 3 enzymes tested. Fraction 6 (the main constituent was 1,2-Benzenedicarboxylic acid), possessed the strong activity against the 3 enzymes with inhibition percentage of 96% (IC50 = 56), 91% (IC50 = 44) and 89% (IC50 = 25) against 5-lipox, AChE and COX-2 enzymes, respectively. Fractions 1 and 3 (containing pyrrolidine related compound) showed inhibitory effects against the three enzymes with inhibition percentages ranging between 89 and 75%. The tested materials showed no cytotoxic effects at the highest concentration used (50 μg mL1) against the normal synovial cells but they possessed activities against the induced RA cell. The results indicated that the activities were dose-dependent. Conclusion: The metabolites obtained from B. cylindrica in this study possessed inhibitory effects on pro-inflammatory enzymes and cell viability of the induced RA cell line. These results provide scientific validation of the bio-efficacy of B. cylindrica as a source of potential bioactive substances for the treatment of inflammatory and arthritis-related diseases. Further study is needed to assess the observed bio-efficacy on an in vivo experiment.
  Arif Azizi Che Harun , Nor Aini Huda Mohammad , Mhd Ikhwanuddin , Noraznawati Ismail , Zaharah Ibrahim and Nor Azman Kasan
  Background and Objective: Biological flocculant or bioflocculant have been used in aquaculture industry as it can be applied easily and are environmentally friendly. Biofloc technology has been used in aquaculture using bioflocculant concept or mechanisms. This study was aimed to test and applied bioflocculant-producing bacteria isolated from biofloc for flocculation process potentially used as inoculum for rapid formation of biofloc. Materials and Methods: For the purpose of this study, isolated bacteria from the biofloc sample were identified as bioflocculant-producing bacteria using yeast peptone glucose agar as it shows highly mucoid and ropy colonies morphology. From six species of bioflocculant-producing bacteria [(Bacillus infantis (B. infantis), Bacillus cereus (B. cereus), Bacillus safensis (B. safensis), Halomonas venusta (H. venusta), Nitratireductor aquimarinus (N. aquimarinus) and Pseudoalteromonas], there was 64 consortium of bioflocculant-producing bacteria were produced using the sum of combination calculation. These 64 consortium were tested for flocculation activity using kaolin clay suspension method. One-way analysis of variance (ANOVA) with post hoc and Tukey test was used to compare the differences of flocculation activity of each bacterial consortium. Results: Out of the 64 consortium, there were 19 consortium showed more than 80% of flocculation activity. The most consortium that has more than 80% flocculation activity derived from consortiums of single and combination of two bioflocculant-producing bacteria species. Consortium of B. infantis and B. cereus found to have the highest flocculation activity followed by single species of B. infantis and N. aquimarinus which were 94.3, 92.9 and 90.6%, respectively. Conclusion: In this study, each consortium of bioflocculant-producing bacteria produced different types of extracellular polymeric substances thus affecting ability in flocculation activity test. Information on extracellular polymeric substances produced by different consortium of bioflocculant-producing bacteria will potentially to be used as inoculum for rapid formation of biofloc.
 
 
 
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