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Articles by Nikmah Utami Dewi
Total Records ( 2 ) for Nikmah Utami Dewi
  Nurdin Rahman , Nikmah Utami Dewi and Bohari
  Background and Objective: Antioxidants are a necessary nutrient component of the body to prevent and cope with oxidative stress. Avocado leaf allegedly has a natural antioxidant that can meet the needs of antioxidants which are still limited, especially for people with degenerative diseases. This study aimed to identify and analyze the phytochemical content and antioxidant power of avocado leaf extract. Materials and Methods: The type of research is pure experiment. The avocado leaf extraction preparation was macerated using 96% ethanol solvent with a ratio of 1:10 (w/v) for 3×24 h. Phytochemical types analyzed were flavonoids, saponins, polyphenols, tannins, alkaloids and steroids. Measurement of antioxidant activity using DPPH (1,1-Diphenyl-2-picrylhydrazyl) method on avocado leaf extract and vitamin C (control group). Data analysis was unpaired t-test, one-way ANOVA test and linear regression test with significant value was p<0.01. Results: Positive avocado leaf extract contains flavonoids, saponins, tannins and steroids. Antioxidant activity avocado starch extract (absorbance DPPH = 0.797) is strong with IC50 of 72.61 mg L–1 and vitamin C as positive control is also very strong with IC50 (mg L–1) of 23.03. Conclusion: Avocado leaf extract contains phytochemical substances with a strong antioxidant that can be used to prevent and cope with oxidative stress.
  Nurdin Rahman , Sri Mulyani Sabang , Nikmah Utami Dewi and Bohari
  Background and Objective: Preclinical testing of the use of avocado leaf extract for decreasing blood glucose level is still limited. This study aimed to analyze the effect of avocado leaf extract on fasting blood glucose level in male white rats. Materials and Methods: This study was a pre-experiment with six groups of pretest posttest with control group. The samples were male white rats (Rattus norvegicus) of Wistar strain, ±3 months old, with the treatment groups: Group 1: Feed+Streptozotocin (STZ)+10% sucrose+avocado leaf extract dose of 100 mg kg1 b.wt., Group 2: Feed+STZ+10% sucrose+avocado leaf extract dose 150 mg kg1 b.wt., Group 3: Feed+STZ+10% sucrose+avocado leaf extract dose 200 mg kg1 b.wt., Group 4: Feed+STZ+10% sucrose, Group 5: Feed+STZ+10% sucrose+glibenclamide and Group 6: Feed. Data analysis used ANOVA and paired t-test with p<0.05. Results: The early fasting blood glucose level of the white rats was 58-97 mg dL1 (p = 0.897). Giving STZ increases the fasting blood glucose level to 83-128 mg dL1 (p = 0.136). Meanwhile, giving avocado leaf extract on day 14 decreased 68-77 mg dL1 (p = 0.000). Group 2 experienced a significant decrease on day 7, which was 28.22 mg dL1 (p = 0.028) and day 14, which was 31.33 mg dL1 (p = 0.015). Conclusion: Avocado leaf extract with a dose of 150 mg kg1 b.wt. is effective in reducing the high fasting blood glucose level in white rats.
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