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Articles by Neetu Singh
Total Records ( 4 ) for Neetu Singh
  P. Thomas , T.R. Arun , K. Karthik , P.V. Berin , M. Asok Kumar , Neetu Singh , J. Usharani , M. Palanivelu , S.K. Gupta , K. Dhama and K.N. Viswas
  Necrotic enteritis, caused by Clostridium perfringens, is an important bacterial disease of poultry. A suspected case of necrotic enteritis was presented for necropsy from an Indian Kadaknath Fowl flock showing diarrhea and progressive debility. Gross examination revealed necrotic to ulcerative lesions in intestine. The organism was isolated from the intestinal contents, tissue and liver under anerobic conditions. The cultural characteristics and Gram staining were suggestive of C. perfringens. The sequencing of 16s rRNA gene confirmed the isolate as C. perfringens and which was well differentiated from other clostridia associated with avian intestinal tract. This study demonstrates that 16s rRNA gene sequencing can provide rapid and confirmatory identification of C. perfringens. Further, Multiplex Polymerase Chain Reaction (mPCR) was performed for toxinotyping and isolate was found to be positive for α toxin (cpa) and β2 toxin (cpb2), a feature of C. perfringens type A isolates. As some recent studies have highlighted the involvement of NetB toxin in pathogenesis, therefore, PCR was carried out to find the presence of this toxin, the isolate was found to be negative for netB gene. This study emphasizes the molecular characterization and toxinotyping as a rapid tool for detection of C. perfringens from suspected necrotic enteritis cases. Very few reports regarding molecular characterization are available from India, hence it adds to the available data on this important poultry pathogen. Further investigations are required to understand the exact role of NetB toxin in pathogenesis as various studies including the current one reports NetB negative strains involved in necrotic enteritis.
  Pratibha Singh , Neetu Singh and Gautam Palit
  Back ground: Gastro Esophageal Reflux Disease (GERD) is a common disorder, affecting approximately 10-20% of the western population and often has a debilitating effect on the daily lives of patients. Result: GERD can be described as any symptomatic condition or histopathologic alternation resulting from episodes of gastroesophageal reflux. Transient relaxation of the lower oesophageal sphincter is believed to be the primary mechanism of the disease although the underlying cause remains uncertain. GERD usually manifests as heartburn, regurgitation, or dysphagia and predisposes to development of esophagitis, stricture, Barrett’s metaplasia, esophageal adenocarcinoma. The various agents currently used for treatment of GERD include proton pump inhibitors, antacids, H2-blockers, mucoprotective substances and prokinetic agents. Conclusion: This review gives an overview of the pharmacological management of GERD and summarizes the state of the art with these agents.
  Neetu Singh , Pratibha Singh , Gautam Palit and Vijai Lakshmi
  Aim: Preliminary study revealed that gedunin and photogedunin, from Xylocarpus granatum exhibit anti-ulcer property. In an attempt to clarify the mechanism involved in its anti-ulcerogenic potential, an advanced studies to examine their effects on potent gastric acid secretagogues i.e., plasma gastrin and gastric mucosal histamine in pyloric ligation induced ulcer model. In addition, an evaluation of the cytoprotective function of these compounds by assessing the gastric PGE2 levels in alcohol induced gastric ulcer model. Methods: Adult Sprague Dawley rats, weighing 180-220 g procured from National Laboratory Animal Centre, CDRI, were used in the study. Rats were housed three to four per cage, in a room with temperature regulated at 22±2°C, with a 12 h/12 h light/dark cycle (lights on 07:00 h, lights off 19:00 h). Standard chow pellets and water were given ad libitum, except during the period when food deprivation was applied. Compounds of Xylocarpus granatum and standard drugs like omeprazole (10 mg kg-1) and sucralfate (500 mg kg-1) were prepared in 1% carboxymethyl cellulose (CMC) as suspension and administered orally 45 min prior to exposure of ulcerogens to the animals at a volume of 1 mL/200 g of body weight. All animals were deprived of food for 16 h before ulcerogens exposure and were divided into three groups, (n = 6). Control group of animals were treated with vehicle 1% CMC. Compound gedunin and photogedunin (20 mg kg-1, p.o.) were tested against alcohol and pyloric ligation induced gastric ulcer model. Standard anti-ulcer drugs, omeprazole (10 mg kg-1, p.o.) were treated in pyloric ligation model and sucralfate (500 mg kg-1, p.o.) in alcohol induced ulcer model. Results: Gedunin and photogedunin exerted significant acid lowering activity in pyloric ligated rats as evident through reduced free acidity and total acidity as well as in vitro H+K+-ATPase activity. Also, both compounds normalized the plasma gastrin and tissue histamine level compared to ulcerated rats. Contrastingly, both compounds illustrated no significant increase in gastric PGE2 level and mucin content compared to ulcer control rats. Conclusion: Thus, the study suggested that gedunin and photogedunin imparts gastro-protection through antisecretory mechanism.
  Neetu Singh , Rajendra Prasad and Subrato Bhattacharya
  The title compounds Ph3PbSPbPh3 (1) and Ph3SnSSnPh3 (2) were prepared in high yields by a reaction of Na2S, respectively, with Ph3Pb(SOCMe) and Ph3Sn(SOCMe). X-ray crystallographic and density functional studies were made to understand the structure and bonding in these molecules. Though the Pb–Pb distance in 1 is only marginally shorter than the sum of the corresponding van der Waals’ radii, a smaller Pb–S–Pb angle suggests for a Pb···Pb interaction. DFT calculations were performed to analyse the nature of M···M interaction in 1 and 2. Strong intramolecular π–π interactions subsist between the different phenyl rings of the molecules.
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