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Articles by Naresh Singh Gill
Total Records ( 3 ) for Naresh Singh Gill
  Rashmi Arora , Naresh Singh Gill , Sukhwinder Kaur and Ajay Deep Jain
  Abrus precatorius Linn. is a leguminous plant of the fabaceae family whose stem, bark, leave and roots are widely used for medicinal purposes in tropical and subtropical regions of the world. The plant parts are purgative, emetic, tonic, anti-phlogistic, aphrodisiac and anti-ophthalmic agents. The purpose of the present investigation was to study antioxidant, anti-inflammatory and analgesic activity of Abrus precatorius Linn. ethanolic seed extracts by soxhlet method. The free radical scavenging activity of extract was carried out by 1,1-diphenyl-2-picrylhydrazyl method and anti-inflammatory activity by carrageenan induced rat paw edema and analgesic activity carried out by tail flick and tail immersion method. The extract showed significant activity i.e., 80.1±0.34% at 300 μg mL-1. The extract was evaluated for its anti-inflammatory activity it showed significant anti-inflammatory activity i.e., 62.68% at 375 mg kg-1 by carrageen induced method. Further, the extract was evaluated for analgesic activity and the extract showed significant activity at 300 mg kg-1 after 90 min interval by tail flick and tail immersion method. As ethanolic extract of Abrus precatorius Linn. was found to have potent antioxidant, anti-inflammatory and analgesic potential. The present study concludes that seeds of Abrus precatorius Linn. can be used as good natural antioxidant to treat free radical induced disease.
  Naresh Singh Gill and Bhartendu Sharma
  The antioxidant activity of Murraya koenigii (L.) Spreng (Family: Rutaceae), leaves was investigated in male wistar rats. Potassium dichromate was used to induce oxidative stress. The traditional medical literature describes its potential role as a source of many vitamins, flavonoids, phenols and domestic remedy for many human disorders. The whole plant is considered to be tonic, antidiarrhoeal, febrifuge, blood purifier and as stomachic. In the present study animals were divided into four groups Group I (Control), Group II (Potassium dichromate), Group III (Murraya koenigii+Potassium dichromate) and Group IV (Murraya koenigii). in vivo antioxidant activity of Murraya koenigii inhibited the toxicity of potassium dichromate. The GSH content in liver (1.79±0.019) and kidney (1.967±0.013) of Group IV rats significantly (p<0.05) increased whereas, hepatic malondialdehyde content in liver (2.44±0.29) and kidney (2.34±0.057) was significantly (p<0.05) reduced as compare to control. However, Chromate significantly (p<0.05) decreased the reduced glutathione (GSH) content and increases hepatic malondialdehyde (MDA) content in both liver and kidney as compared to control. Further post treatment with Murraya koenigii (Group III) significantly (p<0.05) increase the GSH content in liver (1.54±0.013) and kidney (1.27±0.011) as compared to Group II whereas, hepatic malondialdehyde content in liver (4.24±0.71) and kidney (3.86±0.038) was significantly (p<0.05) reduced as compare to Group II(Potassium dichromate) These results clearly indicate that Murraya koenigii leaves have significant potential as a natural antioxidant agents.
  Naresh Singh Gill and Manoj Bali
  The 9-beta-methyl-19-norlanosta-5-ene cucurbitane glycoside from Cucumis sativus seeds was evaluated for its antioxidant, antiulcer activity. Isolation was done by simple chromatographic technique. The evaluation of antioxidant activity by 1, 1-diphenyl-1-picrylhydrazyl and hydrogen peroxide method further more it was evaluated for antiulcer activity using pyloric ligation, water immersion and non steroidal anti-inflammatory drug (indomethacin) induced gastric ulcer model. The triterpenoid glycosides showed maximum antioxidant activity i.e., 73.21±3.11 and 71.63±2.51% by 1,1-diphenyl-1-picrylhydrazyl, hydrogen peroxide method at 300 μg mL-1, respectively as compared to ascorbic acid. Further, it was evaluated for anti ulcerogenic activity, the compound showed optimum percentage inhibition i.e., 56.6, 68.5 and 62.6% by pyloric ligation, water immersion stress and non steroidal anti-inflammatory drug (indomethacin) induced ulcer modal at 300 μg mL-1 against ranitidine in rats. Thus, it can be concluded that the isolated triterpenoid glycosides may be responsible for the antioxidant and antiulcer activity.
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