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Articles by N. Ara
Total Records ( 2 ) for N. Ara
  N. Ara , M. Rashid and M.S. Amran
  The leaves extract of Catharanthus roseus was investigated for hypotensive and hypolipidemic effects in Adrenaline-Induced Hypertensive Rats (AIHR) and compared with those of nifedipine in a crossover design. The pharmacologically Active components responsible for hypotensive activities were isolated from plant using bioassay guided purification approach and the structure of the compounds were proposed by spectroscopic methods. Catharanthus roseus leaves extract and commercial drug nifedipine were administered through intraperitoneal (i.p) route for one week. Different biochemical parameters such as heart weight, blood glucose level, serum cholesterol level, serum triglyceride level, body weight and the relationships between them were measured. Catharanthus roseus leaves extract at a dose of 30 mg/155 ± 15 g of body weight was injected in rat at every morning during the treatment period. Clinically effective plasma concentration as a hypotensive drug was obtained after the injection of 0.1 mg/155 ± 15 g of body weight of the drug. The Catharanthus roseus leaves extract made significant changes in each cardiovascular parameter after investigation. Catharanthus roseus leaves extract treated animals have shown the hypotensive effects. Hypotensive effects were also shown by nifedipine.
  N. Ara , M.H. Nur , M.S. Amran , M.I.I. Wahid and M. Ahmed
  The research was conducted to investigate the in vitro antimicrobial and cytotoxic activities of leaves and flowers extract extracted from Lippia alba. Disc diffusion technique was used for in vitro antibacterial and antifungal screening. Zones of inhibition were observed in disc diffusion for antibacterial screening against 4 Gram-positive pathogenic and 6 Gram-negative pathogenic bacteria. Among crude extracts chloroform extract showed good activity against all test organisms. A Large zone of inhibition was observed (18 mm) against Vibrio parahaemolyticus. In antifungal screening, the compound showed mild to moderate zones of inhibition against four tested organisms. A Large zone of inhibition was observed against Aspergillus niger (13 mm). Cytotoxic activities of crude extracts were determined using Brine shrimp lethality Bioassay and LC 50 values of standard Vincristin sulphate as positive control, n-hexane and crude ethanol extracts were found to be 5, 15 and 20 μg mL-1, respectively.
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