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Articles by Munir A. Sheikh
Total Records ( 2 ) for Munir A. Sheikh
  Yasmin Sharif , Munir A. Sheikh , M. Anjum Zia and Tahira Iqbal
  Following an oral dose of 250 mg of clarithromycin to 14 healthy adult male volunteers, renal clearance and urinary excretion of the drug and that of endogenous creatinine were determined. Before drug administration control samples and after drug administration blood and urine samples were collected, at predetermined time periods. The plasma and urine samples were assayed for endogenous creatinine by spectrophotometric methods and clarithromycin by microbiological assay. Mean ± SE values for the blood and urine pH mean were 7.9±0.08 and 5.7±0.17 respectively. The rate of urine flow (diuresis) was 0.019±0.003 ml/min/kg and creatinine was cleared at rate of 1.95±0.164 ml/min/kg of body weight. Average±SE value for clarithromycin clearance was 0.54±0.08ml/min/kg and mean±SE value for clearance ratio was 0.31±0.061. Cumulative amount of dose excreted until 24 hrs. showed an average value 6.1±0.76 percent. A significant positive correlation between diuresis and renal clearance of clarithromycin indicate the back diffusion or reabsorption of the drug.
  Asma Ashraf , M. Shahid , Munir A. Sheikh , Jamil Qureshi , A. Ghaffar and Samina Kausar
  The study was conducted to determine the fate of herbicide (isoproturon) in the grain, straw and soil samples for the control of jangli jai in the wheat fields. Arelon (45% isoproturon) at a dose of 3.7 L ha-1 to control jangli jai was sprayed. The wheat control rating of isoproturon in control and treated plots were observed as highly significant (P<0.05). Similarly, isoproturon application has also been found to be highly significant (P<0.05) in increasing the grain yield of treated plots. The residue concentration in the whole plants of treated plot was 0.66 and 0.71 ppm, 0.25 and 0.26 ppm in grain, 0.37 and 0.36 ppm in wheat straw and the soil collected from treated plots contained 1.74 and 1.76 ppm residue of isoproturon determined by thin layer chromatography and spectrophotometric techniques, respectively. Grain and wheat straw samples from control plots contained no residues but soil samples contained 0.014 and 0.018 ppm of isoproturon.
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