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Articles by Muhammad Iqbal Choudhary
Total Records ( 5 ) for Muhammad Iqbal Choudhary
  Sajid Mehmood , Aziz-Ur- Rahman , Zaheer Ahmad , Nighat Afza , Abdul Malik , Habib Ahmad and Muhammad Iqbal Choudhary
  Monoterpene glycosides have been isolated from the ethyl acetate soluble fraction of Indigofera hetrantha and their structures assigned to be 3,7-dimethyl-2(E),6-octadien-5-one-1-O-β-D-6-O-acetylglucopyranoside (1) and 3,7-dimethyl-2(E), 6-octadien-5-one-1-O-[-β-D-6’’-O-acetylglucopyra-nosyl (1’’ → 6’)-β-D-glucopyranoside] (2), on the basis of spectroscopic analysis including 1D and 2D NMR techniques. Compounds 1 and 2 displayed moderate inhibitory potential against the enzyme lipoxygenase.
  Abdul Wahab , Ejaz Ahmed , Sarfraz Ahmad Nawaz , Ahsan Sharif , Rizwan Ul Haq , Abdul Malik , Muhammad Iqbal Choudhary and Mohsin Raza
  Haloxylon recurvum Bunge ex Boiss (Chenopodiaceae) is distributed chiefly from the Mediterranean region to Central and South Asia and traditionally applied externally for a variety of disorders. We investigated the in vivo toxic potential of crude methanolic extract of the whole plant and its n-hexane, chloroform, butanol, ethylacetate and aqueous soluble fractions by determining their acute toxicity and acute neurotoxicity in mice using Lorke`s method and inverted screen test. In vitro studies were also conducted in order to investigate its antilipoxygenase, antibacterial and antifungal activities. All the fractions showed a narrow margin of safety in mice, except the aqueous fraction, which did not produce any mortality even at the highest tested dose (5000 mg kg-1). At non-lethal doses, only the aqueous fraction (TD50 1264 mg kg-1) was found to produce neurotoxicity in mice. In in vitro lipoxygenase inhibition assay, the ethylacetate fraction showed the most significant inhibitory activity. Crude methanolic extract and its butanol soluble fraction showed the most potent antifungal and antibacterial activity for all the materials tested. Thus, this report verifies the traditionally reported toxicity of this plant, as the majority of its components have exhibited a narrow margin of safety, however, they have been found active in in vitro studies, therefore, further studies are required in order to isolate the most active toxic compounds and differentiate them from these fractions.
  Khalid M. Khan , Nosheen A. Rao , Zia-Ullah , Muhammad Ali , Shahnaz Perveen , Muhammad Iqbal Choudhary , Atta-Ur-Rahman and Wolfgang Voelter
  Acridines are well-known group of compounds with a wide variety of biological properties. We describe herein an expeditious approach to prepare anilinoacridine derivatives from mefenamic acid. It is the first report of a one-pot approach to anilinoacridines in good to excellent yields.
  AZIZUDDIN , SAIFULLAH , Saifullah KHAN , Muhammad Iqbal CHOUDHARY and ATTA- UR-RAHMAN
  Biotransformation of dydrogesterone (1) by using cell suspension cultures of Azadirachta indica yielded a metabolite 20R-hydroxy-9β,10α-pregna-4,6-diene-3-one (2). The structure of this compound was deduced on the basis of various spectroscopic techniques.
  AZIZUDIN and Muhammad Iqbal CHOUDHARY
  Several known secondary metabolites, namely lupeol (1), b-sitosterol (2), stigmasterol (3), and 2,6-dimethoxy-4-hydroxy acetophenone (4) were isolated from a folkloric medicinal plant, Tannacetum polycephalum. The structures of these compounds were elucidated on the basis of various spectroscopic methods.
 
 
 
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