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Articles by Mostafa Ghanei
Total Records ( 3 ) for Mostafa Ghanei
  Majid Shohrati , Navvab Shamspour , Fatemeh Babaei , Ali Amini Harandi , Afshin Mohsenifar , Jafar Aslani and Mostafa Ghanei
  Background and aims: The reduced α1-antitrypsin (AAT) activities of some phenotypes have been suggested as contributing to the development of respiratory diseases.
Materials and methods: One hundred patients with respiratory disease following exposure to sulfur mustard were divided into two groups of 50 based on their respiratory symptoms and compared with a healthy control group. AAT phenotypes were determined in the plasma of all patient and control subjects by isoelectric focusing (IEF).
Results: Mean AAT activities in patient and control groups were 3.4 ± 0.3 and 4.2 ± 0.1 μmol min−1 ml−1, respectively (p < 0.001). No phenotypic alterations were detected.
Conclusions: The difference in the clinical pulmonary symptoms of the two groups was attributed to reduced AAT activity, but this was not manifested as phenotypic changes identifiable by IEF.
  Mahvash Jafari and Mostafa Ghanei
  Introduction. Sulfur mustard (SM) is a strong alkylating agent that causes acute and chronic effects on different organs following exposure. Main late respiratory complications are chronic obstructive pulmonary disease, bronchiectasis, asthma, and bronchiolitis obliterans. It seems that oxidative stress plays a major role in pathogenesis of diseases. This study was undertaken to evaluate the long-term effect of SM on plasma, erythrocytes, and brochoalveolar lavage fluid antioxidant defense system in SM-injured patients. Methods. Brochoalveolar lavage fluid, plasma, and erythrocyte samples were taken from 54 patients in the case group exposed to SM and 25 controls with chronic respiratory disease without a history of exposure to SM. Results. Superoxide dismutase, catalase, and glutathione peroxidase activities in lavage fluid, plasma, and erythrocytes were significantly higher in case group. The increased glutathione S-transferase activity in lavage fluid was associated with a depletion of glutathione and an increase of malondialdehyde levels. There was no significant change observed in glutathione reductase activity. Conclusions. The data suggest that oxidative damage might have an important role for patients exposed to SM. SM may induce an oxidative stress response by depleting the antioxidant defense systems and increasing lipid peroxidation in lung cells.
  Mostafa Ghanei , Shiva Alikhani , Iman Adibi , Mehdi Mir Mohammad , Taghi Ramazani and Jafar Aslani
  The aim of this study was to determine the occurrence of emphysema and accuracy of Pulmonary Function Test (PFT), comparing with chest High Resolution Computed Tomography (HRCT), in smokers with history of exposure to toxic fumes (Sulfur Mustard; SM). This was a cross sectional study (2003-2004) on 20 symptomatic smokers with mild SM exposure (Group 1) and 20 smokers without SM exposure (Group 2). PFT and chest HRCT were performed for all patients to detect emphysema. Sensitivity, specificity and positive and negative predictive values were calculated for PFT. Spirometry did not diagnose emphysema in group 1 while chest HRCT diagnosed five patients (sensitivity = 0). Group 2 developed emphysema (11 of 20, 55%) more frequently than group 1 (5 of 20, 20%, p<0.05). No alpha-1 antitrypsin deficiency was found in all 70 individuals. We conclude that smokers with an additional risk factor, such as exposure to toxic fumes, develop emphysema at younger ages while they have normal PFT. Chest HRCT should be regarded as a useful tool in the early diagnosis of emphysema in such cases.
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