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Articles by Mohd Fadzelly Abu Bakar
Total Records ( 4 ) for Mohd Fadzelly Abu Bakar
  Asmah Rahmat , Susi Edrini , Abdah Md. Akim , Patimah Ismail , Taufiq Yap Yun Hin and Mohd Fadzelly Abu Bakar
  The antiproliferative activities of Strobilanthes crispus was evaluated using (3-[4,5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazoliumbromide) (MTT) assay against several cancer cell lines and Chang liver (normal) cell lines. The methanolic extracts of Strobilanthes crispus displayed the strongest cytotoxic effect on colon cancer (Caco-2) followed by human breast cancer hormone non-dependent (MDA-MB-231) and liver cancer (HepG-2) with IC50 values of 22.3, 27.2 and 29.3 μg mL-1, respectively. The chloroform extract of this plant was shown to also have cytotoxic effect against Caco-2 and HepG-2 with IC50 values of 25.1 and 28.0 μg mL-1, respectively. β-sitosterol and stigmasterol were isolated from the leaves of Strobilanthes crispus. β-sitosterol displayed cytotoxic properties against Caco-2, HepG-2 and MCF-7 with IC50 values of 20.0, 53.0 and 71.2 μM, respectively. Whereas, stigmasterol inhibited the proliferation of Caco2, HepG2, MCF-7 and MDA-MB-231 with IC50 values of 132.5, 182.5, 156.0 and 185.9 μM, respectively. There was no cytotoxic effect observed on normal cell lines (Chang liver) in all samples tested.
  Mohd Fadzelly Abu Bakar , Arnida Hani Teh , Asmah Rahmat , Fauziah Othman , Normah Hashim and Sharida Fakurazi
  Regarding to the promising pharmacotherapeutic properties of Strobilanthes crispus (Acanthaceae) plant, we report here, the development of nutraceutical herbal tea from S. crispus young and old leaves and evaluate the potential antiproliferative properties and antioxidant activity in vitro. Unfermented and fermented tea (Camellia sinensis) preparation was applied for development of S. crispus tea. Antiproliferative properties of S. crispus tea extracts were determined by the microculture tetrazolium salt (MTT) assay against human breast cancer cell lines (hormone dependent, MCF-7; non-hormone dependent, MDA-MB-231). The results showed that S. crispus tea only inhibit the proliferation of human hormone dependent breast cancer cell lines (MCF-7) but not the non-hormone dependent breast cancer cell lines (MDA-MB-231). The antioxidant activity was determined using FRAP (Ferric Reducing/Antioxidant Power) and DPPH free radical scavenging assay. The results showed that the hot water extract of S. crispus tea showed high antioxidant activity especially S. crispus unfermented tea from old leaves. But the tea from the leaves of C. sinensis displayed better antioxidant activity.
  Asmah Rahmat , Bibi Rohaniza Baharudin and Mohd Fadzelly Abu Bakar
  The antidiabetic effect of crude extract of Andrographis paniculata leaves were studied on normal and alloxan induced hyperglycaemic rats. Oral administration of Andrographis paniculata leaf extract (10 mg kg-1 body weight) for 8 weeks resulted in significant reduction in glucose level as well as increased in body weight in alloxan induced hyperglycaemic rats but not in normal rats, which clearly shows the antidiabetic properties of Andrographis paniculata crude extract. The effect of the extract at dose 10 mg kg-1 body weights was more effective than tested hypoglycaemic agent (glibenclamide) at dose 10 mg kg-1 body weights in restoring the values of these parameters.
  Asmah Rahmat , Susi Edrini , Patimah Ismail , Taufiq Yap Yun Hin and Mohd Fadzelly Abu Bakar
  The aimed of this study is to extract the essential oil from Strobilanthes crispus (Acanthaceae) and Lawsonia inermis Linn (Lythraceae) and to investigate the chemical constituents, antioxidant activity and cytotoxicity effects of these oils on several cancer cell lines and normal cell lines. From GC-MS analysis revealed that the presence of at least 28 components for Strobilanthes crispus and 23 components in Lawsonia inermis. The total antioxidant activity from (FTC) and (TBA) methods showed that the essential oils of both plants have higher antioxidant activity compared to α-tocopherol. The essential oil from Lawsonia inermis displayed the strongest cytotoxic effect on liver cancer cell lines (HepG2) with IC50 (concentration that inhibit 50% of cell proliferation) value of 24 μg mL-1. However, the essential oil from Strobilanthes crispus did not give any cytotoxic value against all the cell lines tested. No cytotoxic effects of both oils in normal cell lines. The essential oils from both plants can be used as nutraceutical supplement to increase antioxidant needed in body to enhance defence systems, especially towards the incidence of degenerative diseases. The essential oil from Lawsonia inermis can be used as supplement in cancer patients especially in liver cancer patients.
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