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Articles by Mohammad Kazem Gharib Naseri
Total Records ( 3 ) for Mohammad Kazem Gharib Naseri
  Mohammad Badavi , Fatemeh Zarea Mehrgerdi , Alireza Sarkaki , Mohammad Kazem Gharib Naseri and Mahin Dianat
  The main objective of this study was to evaluate the potential protective effect of red Grape Seed Extract (GSE) on lead induced hypertension (HTN) and Heart Rate (HR) in male Wistar rats. The rats were randomly assigned to one of 4 groups: Each group received lead acetate (100 ppm in drinking water), GSE (100 mg kg-1, orally) or Lead + GSE for 45 days. Another group assigned as control group provided with tap water and regular pellet food. The Systolic Blood Pressure (SBP) and heart rate were determined by tail plethysmography coupled to a computer system. There was a sustained elevation of SBP in lead exposed rats that significantly increased at day 18 (lead treated, 112.7 ±2.7 mmHg, vs. control, 105.6±2.6 mmHg, n = 10, p<0.05) and reached a maximum level at day 36 (lead treated, 124.9 ±2.3 mmHg, vs. control, 103.6 ±3.1 mmHg, n = 10, p<0.001). However, the other three groups; showed no significant changes in SBP. Furthermore, the heart rate was increased sustainly in lead exposed animals that was statistically significant at days 36 and 45 (lead treated group, 404.5±9.4 vs. control group, 381.7 ±6.7, n = 10, p<0.05). The blood lead level in both lead and lead + GSE treated groups was increased significantly compared with control and GSE treated groups (p<0.001). However, GSE administration had no effect on the blood lead level in lead treated group. According to the result of this study, it may be concluded that GSE could have beneficial effect in protecting the cardiovascular system through its antioxidant activity against oxidative stress.
  Mohammad Kazem Gharib Naseri , Maedeh Arabian , Mohammad Badavi and Akram Ahangarpour
  The aim of present study was to investigate the effect of onion (Allium cepa) peel hydroalcoholic extract (OPE) on rat hypertension induced by high-fructose diet and aorta contractility. The OPE was prepared by maceration method using 70% ethanol. The thoracic aorta from male adult rat (Wistar) was dissected and suspended in Krebs-Henseleit solution under 1 g resting tension. Tissue preparation was contracted by KCl (80 mM) or phenylephrine (Phe, 1 μ M) and then the extract was applied cumulatively (0.0625-2 mg mL-1). Hypertension was induced in negative control and three groups of rats by adding fructose (10% W/V) in drinking water for 6 weeks but control group received tap water. Hypertensive groups received saline or OPE at 200, 400 and 800 mg kg-1 daily for last 3 weeks by gavage. Results showed that OPE reduces aorta contractions induced by KCl or Phe in a concentration-dependent manner (p<0.001). Removing aorta endothelium did not attenuate the OPE activity. Inhibition of nitric oxide, cGMP and prostaglandin synthesis by L-NAME (100 μM), methylene blue (10 μM) and indomethacin (10 μM), respectively, did not attenuate OPE activity. Atropine abolished ACh-induced relaxation in Phe precontracted aorta but not the OPE-induced relaxation. Although the extract did not change heart rate but after 3 weeks reduced the hypertension induced by fructose (p<0.001). Present results indicated that OPE reduces aortic contractions possibly via inhibition of calcium influx but without involving NO, cGMP, endothelium and prostaglandins. The OPE hypotensive effect could be due to extract quercetin content, antioxidant activity and inhibiting vascular smooth muscle cells Ca2+ influx.
  Mohammad Kazem Gharib Naseri , Zahra Gharib Naseri , Maryam Mohammadian and Marzie Omidi Birgani
  The effect of Mentha longifolia (L.) leaf hydroalcoholic extract (MLE) was examined on rat ileal smooth muscle contractions. Last portion of ileum from male adult Wistar rat was mounted in an organ bath containing Tyrode solution. The tissue was contracted by carbachol (CCh, 10 μM), KCl (60 mM) and BaCl2 (4 mM) and then MLE (0.0625-1 mg mL-1) was added to the bath cumulatively. The effect of MLE on KCl-induced contraction was examined after tissue incubation with propranolol (1 μM), naloxone (1 μM) and Nω-nitro-L-arginine methyl ester (L-NAME, 100 μM). The effect of MLE on CaCl2-induced ileal contraction in Ca2+-free with high potassium Tyrode solution was also evaluated. The role of potassium channels was examined by ileum incubation (5 min) with tetraethylammonium (TEA, 1 mM). The results showed that KCl-, CCh and BaCl2-induced ileal contractions were inhibited (p<0.001) by cumulative concentrations of MLE with the same potency. In addition, MLE (0.25-1 mg mL-1) inhibited (p<0.01) ileal contractions induced by CaCl2 (0.45-2.7 mM) in a concentration-related manner. The antispasmodic effect of MLE was affected neither by propranolol, L-NAME nor by naloxone. The MLE concentration-response curve was shifted to the right (p<0.05) by tissue incubation with TEA. From results it may be suggested that Mentha longifolia hydroalcoholic leaf extract induces its spasmolytic activity mainly through disturbance in calcium mobilization and partly by potassium channels activation. Present results show that Mentha longifolia leaf extract exerts relaxant effects on intestinal smooth muscle, consistent with the traditional use of the plant to treat gastrointestinal disorders such as diarrhea and colic.
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