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Articles by Mohammad Hosein Farzaei
Total Records ( 2 ) for Mohammad Hosein Farzaei
  Mohammad Hosein Farzaei , Roja Rahimi , Zahra Abbasabadi and Mohammad Abdollahi
  Many medicinal plants have been identified in Traditional Iranian Medicine (TIM) for the treatment of Peptic Ulcer (PU) but they are still unknown to scientific community. In the present study anti PU activity of these remedies were systematically reviewed and identified. For this purpose, medicinal plants proposed for the management of PU in TIM were collected from TIM sources and they were searched in modern medical databases like PubMed, Scirus, Sciencedirect and Google Scholar to find studies confirmed their efficacy. Findings from modern investigations support the claims of TIM about the efficacy of many of these plants in PU. For example, the oleogum resin of Boswellia carterii and B. serrata as a beneficial remedy for PU in TIM were demonstrated to have wound healing, cytoprotective, antisecretory, antacid, prostaglandin production and inflammatory modulating properties. Fruit and leaves of Myrtus communis was found to be antioxidant, anti H. pylori, wound healing, antisecretory, antacid and cytoprotective. The aerial part from Melissa officinalis exerts its beneficial effects in PU by antioxidant, anti H. pylori, prostaglandin elevating, cytoprotective, antisecretory, antacid and leukotriene reducing properties. Furthermore, Polygonum species demonstrated its function on PU with prostaglandin enhancement, inflammatory modulation, wound healing, cytoprotection, antacid, antioxidant and anti-H. pylori activity. In contrast, for some of herbal remedies used in TIM such as Dolichos lablab flower, Symphytum species, Zizyphus spina-christi fruit, Alisma plantago-aquatica, Cupressus sempervirens fruit, Acacia Arabica gum, Cyperus species root, Althaea officinalis flower and Nymphaea alba flower there is no enough evidence in modern medicine to prove their effectiveness in the management of PU. Pharmacological and clinical studies for evaluation of efficacy of these herbs in PU and their possible mechanisms of action are recommended.
  Mohammad Hosein Farzaei , Roja Rahimi , Fatemeh Farzaei and Mohammad Abdollahi
  Diabetes mellitus is a complex metabolic disease associated with impaired insulin secretion, developing insulin resistance as well as β-cell dysfunction, that leads to abnormal glucose, protein and lipid metabolism, inflammatory responses and oxidative damages. Traditional medicines suggest a wide range of remedies for the management of symptomatologies associated with chronic disorders including diabetes mellitus. The aim of the present study is to elicit the most popular traditionally used medicinal plants for diabetes and review literatures in order to scientifically evaluate their efficacy and safety in diabetes mellitus and its complications. In addition, their molecular and cellular mechanisms of action along with active phytochemical agents were highlighted. The findings demonstrated that traditional herbal remedies perform their antidiabetic potential through different cellular and molecular mechanisms, including enhancing insulin secretion, regeneration of pancreatic β-cell, improving insulin resistance, α-glucosidase enzyme inhibitory activity and anti-inflammatory effects as well as attenuating diabetes associated oxidative stress. Suppressing hepatic glucose output and enhancing glucose uptake as key contributors in antidiabetic effect of natural remedies are mediated via stimulating glycolysis, glucose oxidation and glycogenesis, along with reducing glycogen degradation and gluconeogenesis. Since traditional natural remedies are commonly used by diabetic patients, interaction between herbs and conventional antidiabetics has also been highlighted in this study. Overall, traditional herbal remedies are possible antihyperglycemic therapeutic adjuncts and potential source of new orally active agent(s) for management of diabetes; however, more well-designed clinical trials are suggested to recognize higher levels of evidence for the confirmation of their efficacy and safety.
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