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Articles by Mohamed A. Al- Omar
Total Records ( 6 ) for Mohamed A. Al- Omar
  Said A. Said , Abd El-Galil E. Amr , Hassan A. El- Sayed , Mohamed A. Al- Omar and Mohamed M. Abdalla
  Some of synthesized heterocyclic pyrimidine, pyrimidine, furopyridine derivatives and their nucleoside candidates (2-14) were previously prepared and were founded to have some aspects of structural similarity with many anti-inflammatory agents. Therefore, these agents were screened for this property. The evaluation of the anti-inflammatory activities was based on evaluation of the abilities of these compounds in protection against carrageenan-induced edema. The anti-inflammatory activities of the tested compounds further confirmed based on evaluation of the abilities of these compounds to inhibit plasma PGE2. These compounds showed potent anti-inflammatory activity with low toxicity (LD50) comparable to Valdicoxib® as reference anti-inflammatory drugs.
  Abd El-Galil E. Amr , Mohamed A. Al- Omar and Mohamed M. Abdalla
  Here the report antiulcer activity of some 2,6-bis substituted pyrimidothienopyridine (1-9). Eighteen pyrimidothienopyridine derivatives were synthesized and screened as analgesic, anticonvulsant and antiparkinsonian agent before. Many pyrimidines derivatives were synthesized and showed wide diversity of excellent biological activities, the most interesting one amongest these activities the antiulcer activates. It was proven that the antiulcer activities of many pyrimidines derivatives were due to their proton Pump Inhibitor Activities (PPI). Herein and due to structure similarity between the compounds in study and some pyrimidines derivatives showed potent antiulcer activities, the antiulcer activities of these compounds were evaluated using pyloric ligation ulcer model. All the tested compounds showed potent antiulcerogenic activities and the potency descending order was 6b, 6a, 5b, 5a, 7b, 7a, 9b, 9a, 8b, 8a, 2b, 2a, 3b, 3a, 4b, 4a, 1b and 1a. To specify the accurate mechanism of antiulcer activity, many animal models were used the only one that give fruit results was H+/K+-ATPase inhibition in membrane vesicles of stomach mucosa that proved all antiulcer activities of the tested compounds accomplished via H+/K+-ATPase (proton pump) inhibition activities.
  Ahmed M. Naglah , Mohamed A. Al- Omar , Samy M. El- Megharbel and Moamen S. Refat
  Metal complexes have been applied as medicinal agents in the treatment of different human infections and diseases. So, the aim of this study is focused on studying the spectroscopic, thermal and evaluating antimicrobial investigations of ibuprofen analgesic drug complexes formulas with Cu (II), Ni (II), Ag (I), Hg (II), UO2 (II), Cd (II), Ba (II) and Al (III) metal ions. Complexes of Cu (II), Ni (II), Ag (I), Hg (II), UO2 (II), Cd (II), Ba (II) and Al (III) with ibuprofen ligand as to evaluate the biological activity were synthesized and characterized by elemental analysis, conductometry, magnetic susceptibility, UV-VIS, IR, 1H-NMR spectroscopy and thermal analysis. The IR spectral data suggested that the ibuprofen ligand behaves as a monobasic bidentate ligand towards the central metal ion with deprotonated of carboxylic group. From the microanalytical data, the stoichiometry of the complexes 1:1, 1:2 and 1:3 (metal: ligand) was found. The metal complexes were screened for antibacterial activity against Gram -ve organisms as Escherichia coli and Pseudomonas aeruginosa, Gram +ve organisms as Bacillus subtilis and Bacillus cereus and antifungal organisms such as Aspergillus niger, Aspergillus flavus and Aspergillus oryzae. The resulted Ibu compounds has proved the thermal stability feature. The antimicrobial activities of the metal complexes of Ibu recorded a significant effect against some bacteria and fungi.
  Ahmed M. Naglah , Mohamed A. Al- Omar , Abdel Majid A. Adam and Moamen S. Refat
  Saccharin (sacH) is a sugar substitute sweetening agent used extensively in dietary products. It is about 300 times sweeter than sucrose. This study highlighted the structural chemistry of Charge Transfer (CT) complexes formed from the interactions of two acido acceptors (CLA and PA) with sacH. The IR and 1H NMR revealed evidence of significant intermolecular interactions between N-H group in the sacH and O-H group in the acido acceptors based on their characteristic shifts. The TG and DTA experiments were carried out to investigate the thermal properties of the obtained complexes. Their morphological features were also investigated using Optical Light Microscope (OLM). The OLM micrograph patterns indicate the formation of high quality colored crystals. This study provided the essential basics for understanding the complexation chemistry of saccharin.
  Abd El-Galil E Amr , Mohamed A. Al- Omar and Mohamed M. Abdalla
  A series of chiral linear and macrocyclic bridged pyridines (1-8) has been prepared starting from pyridine-2,6-dicarbonyl dichloride and they screened as antimicrobial agents before. Screening of the compounds for their Inhibition of type A and type B monoamine oxidase activities in mitochondria preparation revealed that the tested compounds showed selective inhibition of type A monoamine oxidase activities in the following order 4a, 6, 5a, 3, 4b, 5b, 1, 4c, 7, 8 and 2, this confirmed by the in vivo tryptamine seizure potentiation model in rats. The tested compounds showed in vivo good pharmacokinetic and pharmacodynamic profiles.
  Abd El-Galil E Amr , Mohamed A. Al- Omar and Mohamed M. Abdalla
  A series of synthesized 2,6-bis(tetracarboxamide)-pyridine and macrocyclic tripeptide derivatives 1-6 were previously prepared and screened as antimicrobial, anti-inflammatory and anticancer agents. The compounds for evaluation of analgesic, anticonvulsant and antiparkinsonian activities were used. Analgesic activities of selected compounds determined by hot plate assay, all tested compounds showed this property. Anticonvulsant activities of selected compounds measured their abilities to antagonize yohimbine-induced clonic seizure, all tested compounds showed this property. The antiparkinsonian activity measured by the ability of compounds to protect animals against the parkinsonian like signs induced by agonists, all tested compounds showed this property. All tested compounds showed analgesic, antipakinsonian and anticonvulsant activities and the order for these activities were 5b, 6a, 3, 5a, 5c, 4, 6c, 2, 6b and 1.
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