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Articles by Min Zhou
Total Records ( 10 ) for Min Zhou
  Wei Chen , Hao Luo , Min Zhou , Zhe-Ming Lu , Yong-Heng Shang and Fa-Xin Yu
  In this study a level converter based on GaAs pHEMT technology for a MFC (Multifunctional Chip) is designed, simulated and tested for the application of T/R (Transmit/Receive) module for an X band phase array radar system. It has the advantages of smaller chip size, lower power consumption, higher efficiency, lower cost and high stability. The circuit design is based on a feedback and feed-forward network which compensates the chip process variations during the wafer fabrication and operation temperature changing. It results the designed chip has a high stability. Its supply voltage is -5 v with a shared bias generator, this allows reducing the power consumption compared with the other design at -7.5 v in the literature. The testing results have shown that the proposed novel design has met all the specifications given in this project.
  Yi Zhang , Jinping Liu , Min Zhou , Feifei Liu , Lin Lan and Rui Zhang
  A large body of evidence has demonstrated that COO stereotype is a typical cognitive bias of Chinese consumers, how to inhibit the stereotype is an important research proposition. This study tends to choose information of two product-related attributes and information of two non-product-related attributes through reports materials of negative information of foreign brands in media in recent years to constitute four experimental groups. It finds that the negative information involving quality and price profiteering is of significant inhibition on quality evaluation, attitude preference and purchase intention of subjects on specific foreign brands while the negative information involving commercial bribery is not of significant inhibition, which shows that the inhibition on specific foreign brand preference by negative information of foreign brands is related to differences of product attributes. The inhibition on subject’s quality evaluation, attitude preference and purchase intention of abstract foreign brands by negative information involving food quality is significantly higher than by information of notebook quality, price profiteering and commercial bribery, which shows food safety is of the highest accessibility. Meanwhile, the quality evaluation, attitude preference and purchase intention of specific foreign brands by subjects are lower than those of specific local brands, which shows a significant inhibition on foreign brand preference and local brand bias by negative information of foreign brands.
  Xia Hu , Min Zhou and Shuang Li
  As is growing interest in the conduct of business transactions by electronic means through the Internet and dedicated networks this is often referred to as Electronic Commerce (EC). This paper reviews developments in electronic commerce with a particular focus on its applicability and uptake within the construction industry. Electronic commerce business models are reviewed and the enablers and barriers to their uptake in the construction sector presented. Therefore this paper concludes with future trends in electronic commerce and the need for construction organizations to make the necessary investments that will enable them to take advantage of these and further aiming to contributing in solving this problem by applying automated safety rule checking to enterprise information construction and countermeasure research under the environment of electronic commerce.
  Xia Hu , Min Zhou and Qing Xia
  In various wireless sensor networks applications, the sensor node positioning problem is the basis and key technology of IOF (internet of things), which is essential for IOF monitoring activities. Due to the influence of environment and many other factors, the data collected by sensor node is easily generate errors, leading to the existing location algorithm or model positioning effect not so satisfactory. Aiming to this problem, this paper using internet (Geometric) topology structure information, based on the model of Location Estimation-Locality Preserving Canonical Correlation Analysis (LE-LPCCA), through transforming the depiction of signal space and physical space local information, proposed a new IOF positioning model LE-RLPCCA. Compared with the kind methods at present, model LE-RLPCCA has a better robustness of error-tolerance technology, positioning accuracy and stability improved evidently.
  Qin Zheng , Yongheng Shang , Zhiyu Wang , Jiarui Liu , Min Zhou , Xiuqin Xu , Liping Wang , Hua Chen , Zhengliang Huang , Zheming Lu and Faxin Yu
  In this study, an automated testing system for a reflection-type Vector Modulators (VM) comprised of a Field Programmable Gate Array (FPGA) and a LabVIEW based testing software is presented. The testing system with a friendly Graphic User Interface (GUI) is able to evaluate all the functionality of the VMs and allows the user to test the FPGA module step-by-step or to automate the testing in a sequential way. In case of multiple VM testing, all the VMs can be tested in one time by automatically sending the control commands to manipulate the bias voltage of each VM. Only one FPGA based hardware is needed in the testing system for the bias voltage control. This present testing system is highly efficient for VM testing and can be easily generalized to the testing of other VMs.
  Wei Chen , Xiuqin Xu , Hui Xu , Ming Hong , Zhiyu Wang , Yongheng Shang , Dongdong Liu , Min Zhou , Zhengliang Huang and Faxin Yu
  This study presents the temporal Coupled-Mode Theory (CMT) analysis of a K-band MMIC (Microwave Monolithic Integrated Circuit) bandpass filter with dual orthogonal resonant modes. Two test methods are applied and compared in the filter response measurement. The dimensions of the MMIC filter, whose chip size is 1.9×1.35 mm, are optimized based on the FEM (Finite Element Method) simulation assisted temporal coupled-mode theory. As a two-port reciprocal system, the transmission and reflection responses of the filter are deduced. GaAs MMIC IPD (Integrated Passive Device) technology is applied for chip fabrication. The test results using a probe station fit well with the simulation results. A testing fixture is introduced to model the practical application scenario, whose measurement results, after de-embedment, have shown consistency with the simulation and the probe station test results.
  Mengyao Su , Jiarui Liu , Hua Chen , Dongdong Liu , Min Zhou , Zhiyu Wang , Yongheng Shang , Zhengliang Huang and Faxin Yu
  This study presents a design of a highly reliable shift register based on TSMC 0.18 μm process which can efficiently fight against the Single Event Upset (SEU). A bilateral Power on Reset (POR) block, together with bit-line segregation and tri-mode redundancy technologies are applied in this design to comprehensively enhance the SEU hardening performance at both system level and circuit level. Assisted by the theory of transient circuit analysis, the shift register’s SEU hardening performance is achieved from the aspects of both schematic and layout. A current pulse which is used to emulate the SEU effect, is injected in the circuit for verification. The result of simulation shows great improvement of the SEU tolerance. With its high reliability and radiation tolerance, the present shift register can be applied to CMOS chip designs in the field of aerospace.
  Jing Cui , Weiyan Jing , Shuyuan Guo , Jianying Cui and Min Zhou
  Background and Objectives: Breast cancer is one of the leading cancers types globally. Several strategies have been followed to control breast cancer. Triphala is an Ayurvedic formulation that is composed of three different plant extracts. The current work aims at evaluating the effect of Triphala against ovarian cancer cell line PA-1 on the proliferations and the potential molecular mechanism of action. Materials and Methods: Breast cancer PA-1 cell lines were cultured in vitro and proliferation was measured using an MTT assay. Intracellular ROS level was measured using the Dichloro–Dihydro-Fluorescein Diacetate (DCFH-DA) assay and apoptosis were observable with AO/EB staining while; the expressions of associated genes were determined by polymerase chain reaction. Results: Cell viability was reduced by the dose-dependent manner of Triphala. Further, treatment with Triphala induced morphological changes indicative of apoptosis, displayed elevated levels of oxidative stress and typical signs of apoptosis were observable with AO/EB staining. Most importantly, Triphala abolished the cell adhesion in PA-1 cells. At the molecular level, Triphala caused a dose-dependent increase in the expression of cMyc, an oncogene responsible for the induction and maintenance of cancer. Another apoptotic regulator Bax was over-expressed by Triphala. Conclusion: This studies have shown the possibility of exploiting Triphala as an anti-cancer agent, especially against ovarian cancer.
  Anthony J. O`Donoghue , Cathal S. Mahon , David H. Goetz , James M. O`Malley , Denise M. Gallagher , Min Zhou , Patrick G. Murray , Charles S. Craik and Maria G. Tuohy
  The thermophilic filamentous fungus Talaromyces emersonii secretes a variety of hydrolytic enzymes that are of interest for processing of biomass into fuel. Many carbohydrases have been isolated and characterized from this fungus, but no studies had been performed on peptidases. In this study, two acid-acting endopeptidases were isolated and characterized from the culture filtrate of T. emersonii. One of these enzymes was identified as a member of the recently classified glutamic peptidase family and was subsequently named T. emersonii glutamic peptidase 1 (TGP1). The second enzyme was identified as an aspartyl peptidase (PEP1). TGP1 was cloned and sequenced and shown to exhibit 64 and 47% protein identity to peptidases from Aspergillus niger and Scytalidium lignocolum, respectively. Substrate profiling of 16 peptides determined that TGP1 has broad specificity with a preference for large residues in the P1 site, particularly Met, Gln, Phe, Lys, Glu, and small amino acids at P1` such as Ala, Gly, Ser, or Thr. This enzyme efficiently cleaves an internally quenched fluorescent substrate containing the zymogen activation sequence (kcat/Km = 2 x 105 M-1 s-1). Maximum hydrolysis occurs at pH 3.4 and 50 °C. The reaction is strongly inhibited by a transition state peptide analog, TA1 (Ki = 1.5 nM), as well as a portion of the propeptide sequence, PT1 (Ki = 32 nM). Ex vivo studies show that hyphal extension of T. emersonii in complex media is unaffected by the aspartyl peptidase inhibitor pepstatin but is inhibited by TA1 and PT1. This study provides insight into the functional role of the glutamic peptidase TGP1 for growth of T. emersonii.
  Theresa C. O`Brien , Zachary B. Mackey , Richard D. Fetter , Youngchool Choe , Anthony J. O`Donoghue , Min Zhou , Charles S. Craik , Conor R. Caffrey and James H. McKerrow
  Cysteine proteases of the Clan CA (papain) family are the predominant protease group in primitive invertebrates. Cysteine protease inhibitors arrest infection by the protozoan parasite, Trypanosoma brucei. RNA interference studies implicated a cathepsin B-like protease, tbcatB, as a key inhibitor target. Utilizing parasites in which one of the two alleles of tbcatb has been deleted, the key role of this protease in degradation of endocytosed host proteins is delineated. TbcatB deficiency results in a decreased growth rate and dysmorphism of the flagellar pocket and the subjacent endocytic compartment. Western blot and microscopic analysis indicate that deficiency in tbcatB results in accumulation of both host and parasite proteins, including the lysosomal marker p67. A critical function for parasitism is the degradation of host transferrin, which is necessary for iron acquisition. Substrate specificity analysis of recombinant tbcatB revealed the optimal peptide cleavage sequences for the enzyme and these were confirmed experimentally using FRET-based substrates. Degradation of transferrin was validated by SDS-PAGE and the specific cleavage sites identified by N-terminal sequencing. Because even a modest deficiency in tbcatB is lethal for the parasite, tbcatB is a logical target for the development of new anti-trypanosomal chemotherapy.
 
 
 
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