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Articles by Mehdi Nematbakhsh
Total Records ( 2 ) for Mehdi Nematbakhsh
  Mehdi Nematbakhsh , Zahra Heydarzadeh , Lila Borjian and Shaghayegh Haghjooyejavanmard
  Nitric Oxide (NO) donors such as L-arginine are a candidate to restores endothelial function. NO itself may change endothelial permeability which is an important factor to control vascular homeostasis. So, the effect of L-arginine on aorta and coronary arteries permeability was the objective of this study. 20 male rats were randomly divided into two groups of oral administrated L-arginine (4 g/l) and control. After five weeks of experiment, the serum level of nitrite by Griess reagent method and direct blood pressure were measured. The aorta and coronary arteries permeability were determined by extravasation of injected Evan Blue dye. The results indicate that after the 5 weeks of experiment, L-arginine increases mean arterial pressure (group I: 157±6, group II: 108.2±10.1 mmHg; p<0.05) and the serum level of nitrite(group I: 35.69±6.88, group II: 23.21±2.72 µmol/l; p<0.05) significantly. No statistical differences were observed in endothelial permeability of aorta (group I: 66.6±5.4, group II: 85.23±10.64 µg/g.tissue) and coronary arteries (group I: 28.2±3.17, group II: 22.83±1.39 µg/g. tissue) between the groups. Low dose L-arginine may increases the level of nitrite; last metabolite of NO in plasma, but its effect on aorta and coronary arteries permeability is not certain.
  Shaghayegh Haghjooyjavanmard , Mehdi Nematbakhsh and Masoud Soleimani
  Vascular Endothelial Growth Factor (VEGF) and Nitric Oxide (NO) play an important role for maintaining endothelial integrity. The purpose is to investigate the VEGF alteration during early atherosclerosis lesion formation in an animal model of hypercholesterolemia. We also measured nitrite to observe the relationship between VEGF and endothelial NO production. 20 white male rabbits randomly assigned in 2 groups (1% high-cholesterol diet, HC group, n = 14, or standard diet, control, n = 6) for 4 weeks. The serum levels of VEGF and nitrite (NO metabolite) were determined. Fatty streaks were measured in rabbit’s aortas. The results indicated that the serum level of VEGF concentration was significantly higher in hypercholesterolemic rabbits and negatively correlated with fatty streak lesions (r = -0.89, p<0.05). The serum level of nitrite was significantly higher in HC group than the control (p<0.05). There was a significant negative correlation between serum level of nitrite and VEGF (r = -0.55, p<0.05). It is concluded that, the increased VEGF in early atherosclerosis may be regarded as a safeguarding response to endothelial injury, which is responsible for maintaining endothelial integrity.
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