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Articles by Md. Aziz Abdur Rahman
Total Records ( 4 ) for Md. Aziz Abdur Rahman
  Md. Akteruzzaman choudury , Md. Aziz Abdur Rahman and Md. Abdul Gafur
  The research work was conducted to investigate the in vitro antibacterial and cytotoxic activities of a antibiotic metabolite. The chloroform (CHCl3) extract of Yeast extract-broth media (acidic) of an Actinomycetes strain yielded a brown, amorphous antibiotic pigment Di- (2-ethyl hexyl)-phthalate [AK2]. The antibiotic and the extract exhibited significant antibacterial activity against both gram positive and gram negative organisms. The zones of inhibition produced by the test materials were found to be between 10 to 22mm. The Minimum inhibitory concentration (MIC) values of the antibiotic were determined against six strains of bacteria and were found to be between 128 to 256μg ml‾1. The cytotoxic activity of the antibiotic and CHCl3 extract was done by brine shrimp lethality bioassay and the LC50 (median lethal concentration) values were 15.8 and 12.5μg ml‾1 respectively, calculated by extrapolation from graph.
  Naznin Ara Khatune , Md. Ekramul Islam , Md. Aziz Abdur Rahman , Md. Asik Mosaddik and Md. Ekramul Haque
  The potential cytotoxic effect of a new benzofuran derivative, 4-hydroxy hexahydrobenzofuran-7-one isolated from Nyctanthes arbor-tristis Linn was evaluated on Ehrlich Ascite Carcinoma (EAC) cells in Swiss Albino mice. 4-Hydroxy hexahydrobenzofuran-7-one was administered in a daily dose of Bangladesh 20 mg kg-1 of mouse after inoculation of Ehrlich Ascite Carcinoma (EAC) cell to the mice. After 5 days, the growth inhibition of cell in percentage was determined in comparison with control mice and it was found that there was no significant difference between average no. of cells counted after treatment in mice receiving 4-hydroxy hexahydrobenzofuran-7- one and in control mice (2.15±0.031) x 107 vs (3.79±0.019) x107 cells, respectively. The compound inhibited the cell growth by 43.27% only. 4-Hydroxy hexahydrobenzofuran-7-one (20mg kg-1 mouse day-1) over 5 days had no significant cytotoxic effect in mice in dose of 20-mg kg-1 mouse for 5 days.
  Zakia Sultana Sathi , Md. Aziz Abdur Rahman and M.A. Gafur
  A pure antimicrobial compound was isolated from the chloroform extract of the broth culture of Streptomyces species by preparative thin layer chromatography (PTLC) and was characterized as 4-hydroxy nitrobenzene (ZS-3) on the basis of spectral data (UV, IR, 1H-NMR, HMBC and HMQC). The compound showed significant antimicrobial activity against six gram positive bacteria, ten gram negative bacteria and three pathogenic fungi. The minimum inhibitory concentration (MIC) of the compound determined against ten pathogenic organisms was found to be between 32-64 g/ml.
  A.H.M. Khurshid Alam , Md. Harun-or-Rashid , Md. Aziz Abdur Rahman , Abdullahil Baki and M. Golam Sadik
  Phytochemical examination of the petroleum ether extract of Hemigraphis hirta has led to the isolation of squalene (1), lupeol (2) and β-sitosterol (3) by a combination of column and preparative thin layer chromatography. The structures of these compounds were determined by spectroscopic analysis (UV, IR, 1H-NMR, 13C-NMR) as well as by comparison of their spectral data with previously reported values.
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