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Articles by Mansoria Belmokhtar
Total Records ( 1 ) for Mansoria Belmokhtar
  Imene Benyettou , Omar Kharoubi , Nouria Hallal , Hadj Ali Benyettou , Kaddour Tair , Mansoria Belmokhtar , Abdelkader Aoues and Mehmet Ozaslan
  Background and Objective: Aluminium (Al) is a widely recognized neurotoxin that inhibits more than 200 biologically important functions inducing severe behavioral abnormalities, impaired cognitive functions and metabolic dysfunction. The present study was designed to investigate oxidative stress of aluminium induced toxicity in developing rat brain and enlarged to investigate the possible ameliorating role of omega-3 and omega-6 fatty acids with low and high ratio. Methodology: Aluminium was administered intraperitoneally (100 mg kg–1 b.wt., twice a week) to female adult rats. Postnatally (30 days), pups were given orally by gavage the low and high ratio of omega-6/omega-3 for 5 weeks. The antioxidative and protective properties of omega-6/omega-3 ratio against the effects of aluminium toxicity (Al) on behavior, redox status and leptin level was analysed by using the one way ANOVA test. Results: The results revealed that AlCl3 significantly increased (p<0.05) the level of Thiobarbituric Acid Reactive Substances (TBARS), Nitric oxide (NO), the antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and Glutathione Peroxidase (GPx), while Glutathione Reductase (GR) was significantly decreased (p<0.05) in the cerebral cortex in intoxicated pup rats. Moreover, the leptin concentration was significantly increased (p<0.05) in cortex. On the other hand, the results exhibited that, omega-6/omega-3 when given in low or high dose were able to ameliorate the mentioned parameters approaching them to the normal ranges. Conclusion: It is concluded that aluminium may be attributed to induce disturbance of locomotor and stereotype behavior, anxiety, disturb antioxidant system and leptin level. Furthermore, the results suggested that the omega-3 and omega-6 could be able to antagonize Al neurotoxicity perhaps by its antioxidant properties.
 
 
 
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