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Articles by Manoj Singh
Total Records ( 5 ) for Manoj Singh
  S. Manikandan , S. Ganesapandian , Manoj Singh and A.K. Kumaraguru
  The distribution and spatial variation of seagrass in the coral reef ecosystem of the Gulf of Mannar was assisted with Line Intercept Transects (LIT) with help of SCUBA diving during January-March 2009. Overall percentage of seagrass was 63% among this 42% distributed towards the shoreward side and 21% towards the seaward side. There were 13 species of seagrass found, among this Cymodocea serrulata was dominant species and the least was Halophila stipulacea. The shoot density of seagrass varied between 63 and 13.4 shoot m-2 in the shoreward side, while in seaward side it was between 65.1 and 2.4 shoot m-2. Seagrass biomass was 179.2 g dwt m-2 at shoreward side and 63.62 g dwt m-2 at in seaward side. Distribution of seagrass along the islands of Gulf of Mannar varies in a very less proportion. But the spatial variation between the shoreward side and seaward side was very high. The present study reveal that seagrass distribution, diversity; shoot density and biomass were significantly higher in shoreward relative to seaward side. This study of seagrass in Gulf of Mannar would be the base line data to know the changes in seagrass population in future.
  S. Manikandan , S. Ganesapandian , Manoj Singh , N. Sangeetha and A.K. Kumaraguru
  Nowadays, emergence of bacterial resistance poses a significant clinical problem. Hence, the aim of this study was to describe the current susceptibility patterns of Multi Drugs Resistant (MDR) strains of Urinary Tract Infections (UTI) isolates to current chemotherapeutic agents, as well as to find out antimicrobial characteristics in the extract of seaweeds against MDR. The extract of Padina tetrastromatica, Stocheospermum marginatum and Grateloupia lithophila exhibited strong activity against Non-MDR strains, whereas, the extract of Grateloupia lithophila only exhibited moderate activity against MDR strains. The extract of Caulerpa sp., Gracilaria corticata and Valaniopsis paachanima exhibited week antimicrobial activity. The extract of Grateloupia lithophila inhibited the growth of both MDR and Non-MDR Staphylococcus aureus. Moreover, extract of Grateloupia lithophila inhibited the growth of Non-MDR E. coli, Pseudomonas aeruginosa and Klebsiella. From our findings, the most potent antimicrobial seaweed extract was Grateloupia lithophila which showed maximum inhibitory activity against MDR and Non-MDR Staphylococcus aureus. This study recommends extracts of Grateloupia lithophila can also be used as antibacterial substance for treating multidrug resistant microbes causing acquired infections.
  S. Manikandan , S. Ganesapandian , Manoj Singh , M. Anand and A.K. Kumaraguru
  Coral reef ecosystem in the Gulf of Mannar and Palk bay have been extensively damaged due to over fishing, sedimentation, dynamite fishing etc. Coral bleaching is an usual phenomena in summer and at extreme case the bleaching response is fatal to the coral. Bottom temperature during the months of April and May 2010 had significant change in both GoM and Palk bay and ranged between 31 to 31.9°C. Massive corals Porites solida, Porites lutea and Favia spp. and branch corals Acropora cytherea, A. intermedia, A. formosa, A. nobilis and Mantipora digitata were affected. Percentage of coral bleaching during April 2010 was 72 and 75% in GoM and Palk bay, further this level increased to 85.1 and 87.2%, respectively. Coral recovery was found during June to August 2010 in GoM and Palk Bay region. The phenomenon of coral bleaching has been taking place periodically all over the world. Therefore, in spite of the odds, the corals will resurge under the sea, which we need to protect and conserve for our benefit.
  Manoj Singh , S. Manikandan and A.K. Kumaraguru
  The convergence of nanotechnology and biomedical sciences opens the possibility for a wide variety of biological research topics and medical uses at the molecular and cellular level. Current and future research achievements in nanobiotechnology could ultimately lead to the development of revolutionary new modalities of biomolecular manufacturing, early diagnostics, medical treatment and disease prevention beyond the cellular level to that of individual proteins, the building blocks of the life process. This study attempts to explain the diversity of the field, starting with the history of nanotechnology, the properties of the nanoparticle, various strategies of synthesis, the various advantages and disadvantages of different methods and finally ends with its application.
  Vikas DASH , Sujeet K. MISHRA , Manoj SINGH , Amit K. GOYAL and Goutam RATH
  The present study was oriented towards microencapsulation of aspirin and the study of its release kinetics. The desired encapsulation was achieved by emulsion solvent evaporation method using ethyl cellulose (EC), cellulose acetate phthalate (CAP) and their mixture (1:1) of polymeric constituents. Characterization of the formulations was performed by size, shape, drug loading efficiency and in-vitro drug release analysis. The in-vitro release profiles from different polymeric microcapsules were applied on different kinetic models. The prepared microcapsules were found free flowing and almost spherical in shape with particle sizes ranging from 300-700μm, having a loading efficiency of 75- 85%. The best fit model with the highest correlation coefficient was observed in Higuchi model, indicating diffusion controlled principle. The n value obtained from Korsemeyer-Peppas model varied between 0.5-0.7, confirming that the mechanism of drug release was diffusion controlled. Comparative studies revealed that the release of aspirin from EC microcapsules was slower as compared to that of CAP and their binary mixture.
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