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Articles by Mahban Rahimifard
Total Records ( 2 ) for Mahban Rahimifard
  Mona Navaei-Nigjeh , Mahban Rahimifard , Nazila Pourkhalili , Amir Nili-Ahmadabadi , Mohsen Pakzad , Maryam Baeeri and Mohammad Abdollahi
  Oxidative stress is involved in complications of diabetes. This study investigated the hypothesis that the cerium oxide nanoparticle/sodium selenite combination can synergistically improve oxidative stress indexes in vital organs (kidney, heart, brain and lung) of diabetic rats. Diabetes was induced in overnight-fasted male Wistar rats via a single dose of streptozotocin (STZ, 60 mg kg-1). The effective doses of cerium oxide nanoparticle (60 mg/kg/day) and sodium selenite (5 μmol/kg/day) alone or in combination were administered for 14 days to diabetic rats. Rats with blood glucose of more than (300 mg dL-1) were selected and divided into six groups including vehicle control, STZ control, cerium oxide nanoparticles, sodium selenite, combination of cerium oxide nanoparticles with sodium selenite and metal form of cerium oxide. At the end of 2 weeks, organ tissues including brain, heart, lung and kidney of animals were removed and then oxidative stress markers including cellular Lipid Peroxidation (LPO), Total Antioxidant Power (TAP), Total Thiol Molecules (TTM) and Reactive Oxygen Molecules (ROM) were evaluated. Combination of cerium oxide nanoparticles and sodium selenite significantly reduced ROM and LPO levels in all the organs. The results of TTM showed an increase in all tissues expect the lung. TAP increased in combination group in all studied tissues expect the lung. The beneficial effect of cerium oxide nanoparticles/sodium selenite in diabetic rats is mediated through control of oxidative stress mechanisms. These effects were more noticeable in kidney, brain and heart.
  Mahban Rahimifard , Mona Navaii-Nigjeh , Amir Nilli-Ahmadabadi , Nazila Pourkhalili , Maryam Baeeri , Azadeh Mohammadirad and Mohammad Abdollahi
  Glycyrrhizic Acid (GA) a major component of licorice, has been reported to have potent antioxidant effects and used widely throughout the world. In the present study, the effects of GA on the function, viability and level of Reactive Oxygen Species (ROS) in isolated rat pancreatic islets were evaluated. After Laparotomy, pancreas was removed and islets were isolated and incubated in RPMI 1640 for 24 h and then islets were separated. GA at logarithmic doses (1, 10, 100 and 1000 μM) were added to islets and incubated for 24 h and then static insulin secretion was tested. Also, viability of cells and their ROS level were determined using Mitochondrial Toxicity Test (MTT) and fluorometric assay. Then islets were stained by dithizone and observed under microscope. The results of MTT test indicated that rang of 1-100 μM of GA is safe. In the dose of 1000 μM, GA increased ROS and reduced viability of islets. GA at 1 μM significantly increased secretion of insulin via isolated islets in the presence of stimulation level of glucose (16.7 mM). Results of dithizone staining showed a reduction in live cells at high dose of GA. The LC50 study was done to determine the toxicity of GA on rat pancreatic islets and a 24 h LC50 of 15 mM was found. GA showed remarkable anti oxidative effects at low doses and improved islet’s viability and insulin secretion in stimulation level of glucose. Interestingly, high dose of GA induced oxidative stress and reduced function of islets. The results of the present study indicate that GA is a good candidate to be examined in islet transplantation procedures to maintain islets viable and functional.
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