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Articles by Maha Z. Rizk
Total Records ( 3 ) for Maha Z. Rizk
  Hanan F. Ali , Laila M. Faddah , Maha Z. Rizk and Hisham El-Ebiary
  In view of radiation injuries to tissues, the present study was carried out to provide information on the deteriorative effects induced by γ-irradiation (5.7Gy) after 24 h and 14 days and to determine both the prophylactic and curative influences of intraperitoneally administered anserine and/or zinc on liver nucleic acids and on total serum total protein, albumin and also different serum protein fractions, namely, prealbumin, α- and β-lipoproteins, α-1 antitrypsin, α-1 acidic glycoprotein, α-1 macroglobulin, cholinesterase, transferrin, ceruloplasmin, haptoglobin and haemopexin. The data obtained revealed that all liver and serum parameters measured significantly declined in rats exposed to whole body irradiation in the two time phases except for the lipoprotein fractions. Administration of anserine and/or zinc either pre or post radiation dose induced a significant improvement in all parameters. It could be concluded that either anserine or zinc has a pronounced effect in overcoming the disturbances induced by γ-irradiation especially when administered post irradiation and the action of each can be potentiated by supplementation of the other. It is thus recommended to use a collective combination of both anserine and zinc as radioprotectors as well as for treatment of radiation hazards.
  Maha Z. Rizk , Mohga S. Abdallah , Hayat M. Sharara , Sanaa A. Ali , Nabaweya A. Ibrahim and Magda M. Moustafa
  The methanolic extracts of both Cupressus sempiverens and Juniperus phoenicea were investigated for their efficiency in reducing CCl4-induced hepatotoxicity in rats. Several biochemical analyses were performed, namely, serum aminotransferases (AST and ALT), alkaline phosphatase (ALP), bilirubin (Bil), triglycerides (TG) and total cholesterol (HDL and LDL). On the other hand, liver antioxidant parameters, namely, glutathione (GSH), lipid peroxides (LP) and nitric oxide (NO) were also measured. The data obtained demonstrated that rats injected with a single toxic dose of CCl4 and sacrificed after 24 h induced remarkable disturbances in the levels of all tested parameters. However, rats injected with the toxic agent and left for one and a half month to self recover showed moderate improvements in the serum and liver biochemical parameters. On the other hand, treatment with both extracts ameliorated the levels of the disturbed biochemical parameters, Cupressus sempiverens revealing a more remarkable effect. It could be concluded that the two extracts under study possess potent activities against hepatotoxicity compared to hepatic self recovery and may thus be helpful in treatment and safe recovery of liver disorders.
  Maha Z. Rizk , Thanaa A. Fayed , Hohey D. Badawy and Nagy S. El-Rigal
  The levels of lipid peroxides, glutathione, vitamin C, vitamin E catalase and superoxide dismutase enzymes were measured in the livers of Schistosoma mansoni infected mice (CD strain weighing 20-25 g) at different durations post infection (1, 2, 4, 6 and 8 weeks). Moreover, the liver weight, body weight, liver to body weight and total protein were studied in the same animal groups. Control non-infected groups were run simultaneously with each infected mice group. The data obtained showed that lipid peroxides were elevated throughout the different durations of infection while glutathione decreased with infection. On the other hand, both vitamins C and E showed a reduction in the livers of mice during the different durations of infection. The activity of catalase showed an insignificant change after one and two weeks and a high significant decrease in the livers of four, six and eight weeks S. mansoni infected mice, while, superoxide dismutase significantly decreased one and two weeks post infection with a significant elevation four, six and eight weeks post infection. Moreover, a significant reduction was observed in body weight after four, six and eight weeks of infection accompanied with an elevation in liver weight only after six and eight weeks. Consequently, liver weight/body weight showed an elevation after four, six and eight weeks of infection. Finally, the protein content was significantly lower at one, six and eight weeks post infection with S. mansoni. It could thus be concluded that host-parasite association results in production of free radicals as a result of an oxidative stress where the parasites struggle to overcome the immune response of the host and changes in host liver antioxidants occur as a means to scavenge these radicals.
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