|
|
| |
| Articles
by
Madiha Mahmoud |
Total Records (
2 ) for
Madiha Mahmoud |
|
 |
| |
|
| |
Saedia A. Sayed El-Ahl
,
Mai A. Hegazi
,
Madiha Mahmoud
,
Fatma El. Zahraa
,
M. Awadallah
and
Mona A. Abd Rabo
|
| |
The study explores the direct effect of somatostatin (SOM) on some stages of
Schistosoma mansoni. Experimentally infected mice with Schistosoma
mansoni were investigated following administration of either SOM, artemether
(ART) or their combination. Each regimen was administered at 2, 5 and 13 weeks
Post-infection (PI) to separate groups. The most presented period of worm reduction
was in mice group received SOM at 5 weeks PI (44.28%), 2 weeks PI in ART administration
(79.90%) and 2 weeks PI in combined treated group (84.16%). A significant reduction
in mature ova (p<0.05) was recorded in ART and combined treated groups at
administration 2 weeks PI in addition to an increase in immature and dead ova
in all treated groups than controls. The highest percentage reduction of total
egg load was recorded in combined treated groups at 2, 5 and 13 weeks PI (88.4,
85.74 and 56.93%), respectively compared to other regimens. The morphological
changes of the adult worms in SOM treated groups were elongation, erraticism,
agitation and fragility. Male worms showed poorly developed suckers and tuberculations.
Both male and female worms showed empty intestines. In ART treated group the
male worms showed stunted growth and deformity of suckers. In female worms beside
stuntedness, they showed moderately developed ovary, empty intestine and absence
of vitelline glands. These observations were highly pronounced in worms recovered
from combined treated groups. The study concluded that SOM has an inhibitory
role on the parasite of Schistosoma mansoni itself regarding physiological
development, worm reduction, egg production and maturity. |
|
| |
|
| |
Mai A. Hegazi
and
Madiha Mahmoud
|
| |
The study aimed to examine the effect of combined therapy of artemether (ART)
and somatostatin (SOM) on liver fibrosis in experimentally infected mice with
Schistosoma mansoni. Infected mice were investigated following administration
of either SOM, ART or their combination. Each regimen was administered at 2,
5 and 13 weeks post-infection (PI) to separate groups which were respectively
sacrificed at 5, 8 and 16 weeks PI. Liver fibrosis was assessed by chemical
measurement of heptic hydroxyproline as a marker of collagen content in liver.
The extent of infection was monitored by liver egg load. The results were interpreted
in comparison with corresponding ones in untreated S. mansoni-infected
mice and age-matched normal control mice. Combined treated group showed the
highest significant lower mean of hepatic hydroxyproline content than the infected
control in 2, 5 and 13 weeks PI (793.41±64.91, 1010.87±75.67 and
1021.42±135.60) respectively in comparison to control group. ART administration
group attained nearby significant lower measures as that of combined therapy
group in the three successive periods of the experiment (893.57±31.83,
1035.91±42.24, 1228.34±26.52) in comparison to control group.
SOM treated group attained significant lower hydroxyproline content in only
5 weeks PI (1145.30±80.91) and 13 weeks PI (1154.53±60.84). The
study concluded that the combined therapy seemed not to be more effective than
ART alone. By implication SOM therapy does not appear to have an additive effect
on ART treatment. |
|
|
|
|
| |
|
