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Articles by M.T. Gapor
Total Records ( 4 ) for M.T. Gapor
  J. Kamsiah , W. Muhaizan , M.T. Gapor and O. Roslin
  This study examined the effects of vitamin E on the prevention of aspirin induced gastric lesions. Sixty-four rats of Sprague-Dawley species (200-250 g) were randomized into four groups. Group I was fed a normal diet, Groups II to Group IV were fed with palm vitamin E and tocopherol enriched diet in a dose of 100, 150 and 30 mg kg-1 food, respectively. After four weeks of feeding with the respective diets the rats were challenged with a single intragastric dose of 400 mg kg-1 body weight aspirin suspended in propylene glycol. The rats were killed 6 h post-aspirin exposure for the determination of histological changes, gastric lesion index and gastric acid and malondialdehyde. The gastric mucosal thickness was significantly higher in the groups treated with palm vitamin E in the dose of 100 mg kg-1 body weight and 150 mg kg-1 body weight compared to control and tocopherol treated group. Gastric lesions index was significantly lower in all the vitamin E groups compared to control. However, there was no significant difference in ulcer indices between palm vitamin E and tocopherol treated groups. The lower ulcer index and better histological changes were accompanied by lower gastric MDA and gastric acid content. It is concluded that the histological changes post aspirin exposure was better in palm vitamin E treated group compared to tocopherol group. However palm vitamin E in a dose of 100 and 150 mg kg-1 body weight as well as tocopherol in a dose of 30 mg have an equal effect on gastric lesions index, gastric acid and malondialdehyde. It thus appear that the protective effect of vitamin E on aspirin induced gastric lesion mediated through it ability in limiting lipid peroxidation and gastric acid secretion.
  Y. Kamisah , A. Adam , W.Z. Wan Ngah , M.T. Gapor , O. Azizah and A. Marzuki
  Palm olein (PO) and red palm olein (RPO) are rich in tocopherols and tocotrienols. In addition, RPO also contains a high content of carotene. This study was to determine the effect of chronic intake of diets containing palm oils, varying in their vitamin E and carotene contents, on lipid profile in rats. Weaning male Wistar rats were fed either 18% RPO, 18% PO or 18% vitamin E-stripped palm olein (SPO) for 12 weeks. Plasma total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL) and low density lipoprotein cholesterol (LDL) were measured at weeks 4, 8 and 12. Feeding the different types of palm oil did not affect TC and HDL from week 4 through week 12, but there were reductions in TG in all dietary groups at week 12 compared to week 4 but differences between groups were not observed. The RPO group had lower LDL at week 12 (vs weeks 4 and 8) but LDL was not reduced in the PO and SPO groups. TC/HDL was reduced in the RPO group at week 12 compared to both weeks 4 and 8, but the PO group only reduced this ratio at week 12 compared to week 4. This finding suggests that chronic feeding of diets high in palm oils did not cause any detrimental effects on blood lipid profile. In addition, red palm olein which is rich in antioxidants in the forms of vitamin E and carotene, showed better effect in terms of reduction in LDL and TC/HDL.
  A.Y. Asmadi , A. Adam , W.Z. Wan Ngah , M. Norazlina , Y. Kamisah , M.F. Nur-Azlina , M.S. Qodriyah , N.S. Ahmad , M.T. Gapor and A. Marzuki
  The effect of dietary tocotrienols and α-tocopherol acetate supplementation on paraquat-induced lung toxicity was investigated in rats. The administration of a single dose of paraquat (20 mg/kg, i.p.) to rats increased lung malondialdehyde (MDA) levels and produced lung edema. Tocotrienols (150 mg/kg pellet) or α-tocopherol (34 mg/kg pellet) supplementation of two months significantly reduced lung MDA levels in rats exposed to paraquat but lung edema was unaffected. However lower doses of tocotrienols in the diet did not significantly lower lung MDA levels compared with the unsupplemented controls. Our results showed that dietary supplementation of tocotrienols and α-tocopherol provides protection against paraquat toxicity possibly through their antioxidant property.
  Y. Kamisah , M.Y. Norhayati , B. Zakri , M. Mazliadiyana , O. Faizah , M.T. Gapor and A.Y. Asmadi
  This study was carried out to compare the patterns of hepatic distribution of palm vitamin E (palmvitee) in suckling and adult rats. Suckling and male adult Wistar rats were given palmvitee in a dose of 0, 30 or 60 mg/kg body weight intra peritoneally for 14 days. The palmvitee was administered in the neonates from day 1 of life. It contained alpha-tocopherol (α TP, 21%), α-tocotrienol (alpha T3, 17%), Y-tocopherol (Y TP, 4%), Y-tocotrienol (Y T3, 33%) and δ- tocotrienol (δT3, 24%). Twenty-four hours after the last injection of palmvitee, the rats were sacrificed and vitamin E concentrations in the liver of each rat were determined. All isomers of vitamin E were detected in groups given palmvitee. Administration of palmvitee increased total vitamin E and its isomers in suckling rats, and in adult rats that received 60 mg/kg palmvitee compared to the respective control groups. In adult rats given 30 mg/kg palmvitee, all tocotrienol isomers and total vitamin E but not alpha TP and YTP were raised. The patterns of hepatic vitamin E distribution in both groups of palmvitee-treated neonates and adult rats treated with 60 mg/kg palmvitee corresponded well with the composition of palmvitee used, dissimilar to the adult rats given with 30 mg/kg palmvitee which had the highest proportion in alpha TP concentration (64%). This preliminary study showed that tocotrienols were distributed differently in liver when given at 30 and 60 mg/kg body weight, postnatally or during adulthood.
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