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Articles by M.S. Rahman
Total Records ( 14 ) for M.S. Rahman
  A. Sarwar , M.S. Rahman , T.B. Huq , K. Biswas , M.I. Hussain , J.F. Chaity , T. Begum , Md. E. Haque , A. Islam and Mst. M. Begum
  Background and Objective: To compare the prevalence of acute vomiting between patients receiving cisplatin as monotherapy or cisplatin in a combination regimen. Materials and Methods: The study was conducted at Delta Hospital Dhaka on a total of 70 patients (44 male and 26 female). The patients received either cisplatin alone or cisplatin with the following chemotherapeutic agents-docetaxel and 5 fluorouracil, docetaxel, etoposide, doxorubicin and capecitabine. The study was conducted in patients receiving chemotherapy for a total of the first 3 cycles. The patients were told to record the number of episodes of vomiting they experienced during the first 24 h after chemotherapy at each cycle. All 70 patients received prechemotherapy antiemetics a combination of 5HT3 receptor antagonist (ondansetron or palanosetron) and dexamethasone prior to chemotherapy. Results: In patients receiving the combination chemotherapy of cisplatin+docetaxel+5 FU experienced the lowest incidence of acute vomiting and cisplatin+capecitabine receiving patients experienced highest incidence of acute vomiting. All the other combination therapy resulted in emesis comparatively similar to that of cisplatin. In all the regimens except for cisplatin+etoposide the percentage of patients experiencing acute vomiting reduced along with progressive cycles. Conclusion: When cisplatin is given in combination regimen except for the combination regimen of cisplatin+capecitabine there is no significant increase in emesis between patients receiving cisplatin alone or in combination therapy.
  M.J. Islam , Shah Md. Helal Uddin , M.W. Zaman , R.I. Mahmood and M.S. Rahman
  A study was conducted to evaluate the water quality at Matiranga Upazilla under Khagrachari Hill District of Bangladesh. pH values (6.72-7.54) indicated that groundwater was slightly acidic to neutral. Ca (0.4-6.90 mg L-1) Mg (0.55-6.60 mg L-1), Na (4.00-44.00 mg L-1), K (4.75-13.50 mg L-1), HCO3 (0.15-1.20 me L-1 ) and CI (0.30-1.60 me L-1) were predominant along with Zn, Mn and P in lesser amounts. Fe, Cu, As, B and SO4 were found trace to very little amounts. Total dissolved solids (TDS) and sodium adsorption ratio (SAR) values were 35-200 mg L-1 and 0.36-3.40 respectively and indicated that all water were under freshwater’ and excellent’ class respectively. In terms of soluble sodium percentage (SSP), most water was doubtful. SAR (0.36-3.40) and EC (52-300 μS cm-1) values classified the water as CI-SI except one as C2-S1. All water was under the category of soft regarding hardness with ‘suitable’ RSC. Based on As, Fe, Mn, Zn, SO4, NO3 and CI all water was within the safe limit for drinking except 3 samples for Mn and one for As.
  M. Habibur Rahman , M. Badrul Alam , N.S. Chowdhury , M.K. Jha , M. Hasan , M.M. Khan , M.S. Rahman and M. Ekramul Haque
  In the present study crude methanolic extract of Stephania japonica leaf was investigated for possible antioxidant, analgesic and toxic activity. The extract showed antioxidant activity in DPPH radical scavenging activity, nitric oxide scavenging activity and reducing power assays. In both DPPH radical and NO scavenging assay, the extract exhibited moderate antioxidant activity and the IC50 values in DPPH radical scavenging and NO scavenging assays were found to be 105.55±1.06 and 129.12±0.15 μg mL-1, respectively while the IC50 values of ascorbic acid were 12.30±0.11 and 18.64±0.22 μg mL-1, respectively. Reducing power activity of the extract increased in a dose dependent manner. Analgesic activity of the crude extract was evaluated using acetic acid-induced writhing model of pain in mice. The crude extract at 200 and 400 mg kg-1 b.wt. doses displayed significant (p<0.001) reduction in acetic acid induced writhing in mice with a maximum effect of 75.89% reduction at 400 mg kg-1 b.wt. which is comparable to the standard, diclofenac sodium (86.52%). The extract was also investigated for toxic potentiality using Brine Shrimp lethality bioassay. In this bioassay the extract showed significant toxicity to Brine Shrimp nauplii with the LC50 value of 25.19±0.98 μg mL-1. The study clearly indicates that the extract possesses good analgesic and cytotoxic activity along with moderate antioxidant potential.
  Md. Aminul Islam , M.S. Rahman , S.A. Rony , M.J. Uddin , A.K.M.A. Rahman , M.T. Islam and M. Ariful Islam
  Feline Influenza Virus (FInV) and Feline Leukemia Virus (FeLV) are two important viruses causing cat flu and neoplastic disease all over the world, respectively but to the knowledge, there is no epidemiological survey report available for these two killer diseases in cat in Bangladesh. Therefore, the present study was aimed to determine the prevalence of FInV and FeLV infection through an epidemiologic survey in selected areas of Bangladesh. For this purpose, a total 60 randomly selected cats consisting of 48 pet and 12 stray cats at Tangail district in Bangladesh during May to October, 2009 were used. Nasal swab and blood sample were collected from all cats and tested by commercial rapid RapiGEN® Feline Influenza Virus (FInV) Ag Test kit and RapiGEN® Feline Leukemia Virus (FeLV) Ag Test kit, respectively following the manufacturer’s (RapiGEN Inc., Korea) instructions. Results revealed the overall prevalence of feline influenza and feline leukemia recorded 5.0 and 1.67%, respectively in cats. There was no significant relationship between the diseases (FInV and FeLV) and different variables. However, the knowledge of the status of FInV and FeLV in cats in the study area will be helpful to undertake preventive measures for FInV and FeLV infection.
  M.S. Rahman , Kuasha Mahmud , M.S. Hossain and M. Eunus
  An experiment was carried out at Modhupur agro-ecological zone during the period from October 1995 to December 1996 in order to study the effect of different types of settling of different varieties on the yield and yield contributing characters of sugarcane. The yield and yield contributing characters were influenced by the variety and the different types of settling. Results revealed that the variety Isd 16 exhibited the best performance in terms of number of millable cane, weights, heights and finally cane yield. The local variety Misrimala produced higher number of tillers and lower number of millable cane than Isd 16 but yet it produced significantly higher cane girths and weights. The modern varieties Isd 16 and Isd 18 produced higher numbers of millable canes than Misrimala. The polythene bag settling appeared superior to two eyed soil bed settling following by one eyed soil bed settling. The variety Isd 16 produced the highest yield (144.5 t ha-1) with polythene bag settling. In contrast, one eyed soil bed settling yielded the lowest (112.6 t ha-1) with Isd 21.
  B.C. Roy , M.S. Rahman and M.A. Rahman
  Amorphous silica-alumina catalyst samples of different Si:Al ratio as of 90:10, 70:30 and 50:50 were prepared from sodium metasilicate and aluminum sulphate by co-precipitation and gelation methods without pore regulating agent. Surface acidity of these catalyst samples were determined by Tamele method (amine titration method) using n-hexane and n-heptane as solvent instead of benzene used in Tamele method that having a carcinogenic effect and using n-butylamine solution as adsorbate. The effects of concentration of adsorbate, amount of catalyst sample and types of catalyst sample on the surface acidity were studied. Investigation of reproducibility measurement indicated that by selecting a moderate amount of sample and concentration of n-butylamine solution as minimum as possible surface acidity of the silica-alumina catalyst sample could be estimated with a fair degree of confidence. The total surface acidity of all the catalyst samples was greater in n-hexane than that of in n-heptane used as solvent. This result reveals that n-hexane or n-heptane can be used for the measurement of surface acidity of catalyst sample, as solvent instead of benzene in Tamele method but n-hexane is better.
  B. Roy , M.R. Alam , Bikash C. Sarker , M.S. Rahman , M.J. Islam , M.A. Hakim and R.I. Mahmood
  An experiment was conducted on naturally occurring growth substances in aqueous extracts of some common weeds viz., Bathua (Chenopodium album), Bhijli ghas (Striga densiflora), Shetdrone (Leucus aspera), Mutha (Cyperus rotundus ), Chapra (Eleusine indica) and Khude Anguli (Digitaria ischaemum) with the attempt for chemical investigation on effective extracts. Boiled and unboiled extracts of all the weed species under test significantly reduced and delayed germination of wheat and jute seeds compared with control. The highest germination (96 and 85.3%) and maximum growth of wheat and jute were observed in seeds treated with control. The effect of boiled and unboiled extracts of Bathua (Chenopodium album) showed the lowest germination in seeds of wheat. The root and shoot length of wheat and jute were also decreased in presence of the weed extracts. The thin layer chromatography (TLC) examination of crude extract of Khude Anguli (Digitaria ischaemum) showed four separate compound at hex: ethyl acetate (20:1, v/v) and the crude extract of Bathua (Chenopodium album) showed three separate component at hex: ethyl acetate (10:1, v/v).
  M.M.R. Chowdhury , M. Shahjahan , M.S. Rahman and M. Sadiqul Islam
  An experiment on duckweed (Lemna minor) as supplementary feed in monoculture of nile tilapia (Oreochromis niloticus) was conducted for a period of 90 days. The experiment had two treatments each with three replications. In treatment-1 ponds were supplied with duckweed as supplementary fish feed and in treatment-2 ponds were kept as control (without supply of duckweed). Ponds were stocked at a stocking density of 80 fingerlings per decimal. The ponds were fertilized fortnightly with poultry dropping at the rate of 5 kg decimal-1, urea 60 g decimal-1 and TSP 90 g decimal-1. Duckweeds were supplied to the ponds (treatment-1) at the rate of 60% of the total body weight (wet weight basis) of the fish. During the experimental period, the ranges of physico-chemical parameters viz., water temperature, transparency, dissolved oxygen, pH, total alkalinity, free CO2, PO4-P and NO3-N were within the productive limit and more or less similar in all the ponds under treatments 1 and 2. There were 27 genera of phytoplankton under five major groups and 11 genera of zooplankton under three major groups were found in the experimental ponds. Mean survival rates in treatments 1 and 2 were 94.37 and 93.75%, respectively. Specific growth rate (SGR, % per day) of the fish in treatments 1 and 2 were 1.16 and 0.80%, respectively. Calculated net production of the fish in treatment-1 was 16.28 kg decimal-1 year-1 and in treatment-2 was 8.92 kg decimal-1 year-1. By t test it was found that the net production of fish in treatment-1 was significantly (p< 0.05) higher than that of treatment-2.
  Mst. M. Begum , M.S. Rahman , R.R. Swarna , M. Das , A.H.M.R. Imon , I. Jahan , M. Rahman , Md. E. Haque , R.R. Saha , A.H.M. Quamruzzaman , Md. A. Obaida , M. Maniruzzaman , A. Islam , Md. T. Islam and A. Sarker
  Background and Objective: Combination of dosages regimen of an antidiabetic agent (Glibenclamide) with a lipid lowering drug can be an effective medication for the patient with high blood glucose level and liver enzyme disfunctionality. The present study was undertaken to investigate the effect of a fixed dose combination of glibenclamide (1.2 mg/70 kg b.wt.) and simvastatin (10 mg/70 kg b.wt.) on blood glucose and liver enzymes dysfuntionality in alloxan-induced diabetic rats for an extended time period. Materials and Methods: Two protocols were developed to carry out the experiment. The first is designated as 4 weeks short-term and second one is termed as 12 weeks long-term treatment protocols, respectively. Diabetes Mellitus (DM) was induced by single intraperitoneal (i.p.) injection of freshly prepared alloxan solution in 0.9% saline. Diabetic rats received treatment with i.p., injection of glibenclamide (1.2 mg/70 kg b.wt.) and simvastatin (10 mg/70 kg b.wt.) for 4 weeks as monotherapy and combination therapy (glibenclamide 0.6 mg/70 kg b.wt., simvastatin 5 mg/70 kg b.wt.) for 12 weeks. Graph pad was used and the results were expressed as Mean±SEM. A one-way analysis of variance (ANOVA) followed by Dunnett’s post hoc test or students paired or unpaired t-test was used in the study where appropriate. Results: Results were considered to be significant when p-values were less than 0.05 (p<0.05). Combination therapy demonstrated a significant (p<0.05) decrease in blood glucose and liver enzymes elevation compared with diabetic control group. The study also demonstrated that the short term treatment has satisfactory effect on lowering SGPT by 41% and SGOT by 50%. Long term administration of combination therapy showed more significant (p<0.05) potentiality on lowering SGPT (46%) and SGOT (53%), respectively and this level remain steady during total treatment period. Conclusion: The present study demonstrates that combination of glibenclamide with simvastatin at the dose level tested exhibits significant glucose and liver enzymes lowering activity in alloxan induced diabetic rats. When monotherapy with oral antidiabetic agents fails, combination therapy with glibenclamide plus simvastatin seems to be stable and effective for the treatment of diabetes mellitus.
  A. Tabassum , R.R. Saha , M.S. Rahman , M.A. Nure , R. Karim , A.H.M.R. Imon , M. Maniruzzaman , A.K.L. Kabir , A. Islam , J.F. Chaity , B.C. Adhikary , A. Sarwar , T.B. Huq and Mst. M. Begum
  Background and Objective: Pain management has been an area of a great deal of attention for pharmacists for many years. In this study, we report a study which is designed to investigate how a combination of existing effective drugs performs for the relief of pain management. Materials and Methods: A combined solid dosage containing paracetamol (500 mg) and ibuprofen (150 mg) is developed and tested under an observational analytical study. The performance of this combined oral solid dosage named maxigesic tablet in order to reduce pain is investigated on the basis of European patent specification. This assay is carried out by employing HPLC system with UV detection at 222 nm. Results: The results show the presence of active components to the tune of 112.12% for paracetamol and 101.86% for ibuprofen. The formulated solid dosage is further subjected to separate groups of artificially pain induced mice for a comparative study and it shows more efficacy than single analgesic used in pain management. We observe that the respective potencies for paracetamol and ibuprofenare 98.57 and 102.90%. Conclusion: The characterization of both granules and tablets of newly developed formulation demonstrates significant improvement in results of analytical test that not only met the standard specification, but they also reveal that the combined dosage will improve the product quality, efficacy and patient safety in the long run. This trial also shows a significant difference in the percentage of pain inhibition between the two sets of formulations (single and combination of them).
  M. Ashrafuzzaman , M.A.H. Khan , S.M. Shohidullah and M.S. Rahman
  A pot culture experiment was conducted with five levels of salinity (EC 0, 2.0, 4.0, 6.0 and 8.0 dSM-1) obtained by dissolving NaCl in distilled water to study the effect of salinity on chlorophyll content, yield and yield components of Quality Protein Maize (QPM) CV. Nutricta. Ear length, ear diameter, number of seeds per ear and 100 seed weight were also reduced at high salinity levels. Increasing salinity decreased the content of chlorophyll a, chlorophyll b and total chlorophyll and had little or no effect on chlorophyll a/b. A gradual and significant decrease in nitrogen and potassium contents was recorded in maize shoot and grain with an increasing salinity. Accumulation of N+ and K+ in grains were smaller than in shoot or straw. Due to its high yield potential I normal soil and high yield reduction in salinity it is regarded as a highly saline sensitive crop.
  M.S. Rahman , M. Eunus , M. A. Mannan , M. R. Ali and M. M. Hoque
  Two planting methods viz. line and broadcast, five varieties viz. Local, Barimung 2, Barimung 3, Binamung 2 and Binamung 5 and five sowing dates viz. February 5, February 20, March 5, March 20 and April 5 were tested to know the relation between dry matter production and yield of munbean. The highest seed yield (890 kg ha‾1) was obtained from Barimung 2 and significantly higher seed yield (870 kg ha‾1) was obtained from February 20 sowing, while March 20 sowing yielded the lowest (593 kg ha‾1). Barimung 2, Barimung 3 and Binamung 2 performed better in line sowing compared with broadcast method. Line sowing method was found good when the crop was sown on February 20. Binamung 5 gave the highest seed yield (1071 kg ha‾1) when sown on February 20. Binamung 2 gave the highest seed yield (1163 kg ha‾1) when sown on February 20 in line sowing method.
  M.S. Rahman , K. Roy and M.S. Dey
  Production performance of two broiler strains (Starbro and Hubbard) was investigated in three different season of the year under rural environment in Bangladesh. Both strains were reared separately from day old chick to 31 days of age during (October 2001 to September 2002) winter, summer and rainy season. Each season was treated as treatment with 2 batches, each of 50 birds as replicates within the treatment. Live weight gain was highest in winter, lowest in rainy and intermediate in summer and data showed significant differences among the treatment (P< 0.01). In rainy season growth rate was lower in Starbro strains and has a significant difference (P< 0.01) but intermediate in Hubbard with low significant difference (P< 0.05). It concluded that both strains performed well and satisfactorily in rural environment. However, Hubbard seems to be superior to Starbro and Hubbard could be grown profitably and uniformly under rural environment in Bangladesh.
  M.A. Hoque , D.H. Baik , M.S. Hussen and M.S. Rahman
  This experiment was conducted with 21,153 cows and heifers of 3 (three) genetic groups viz. Pabna (PB), PabnaxSahiwal (PBxSL) and PabnaxFriesian (PBxFN) inseminated with frozen semen of Sahiwal (SL), Friesian (FN) and SahiwalxFriesian (SLxFN) bulls to investigate the effects of breeding groups and environmental factors on conception rate (CR). Among the factors considered, it was reflected that parity of dam (p<0.05), time of insemination (P<0.01), season of insemination (p<0.05) and all interactions (p<0.05) had significant effects on CR. The highest CR were found for cows in 0 parity (heifer) (52.11%) or cows inseminated in spring season (51.30%) or inseminated between 8 to 14 hours after onset of estrus (53.24%). The highest CR were also observed in the interaction effects of PBxFN damsxSL sires (52.75%) or SL siresxspring season (52.17%) or PBxFN damsxwinter season (52.21%) or cows inseminated within 8 to 14 hours after the onset of estrusxspring season (54.55%)-indicating that combination of inseminating dams in right time of estrus using appropriate sire in appropriate season would contribute greatly to improve the status of CR in PB and its crossbred with SL and FN cows of Bangladesh.
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