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Articles by M.R. Sulaiman
Total Records ( 6 ) for M.R. Sulaiman
  Z.A. Zakaria , A.M. Mat Jais , M. Mastura , S.H. Mat Jusoh , A.M. Mohamed , N.S. Mohd. Jamil , M.S. Rofiee and M.R. Sulaiman
  The present study was carried out to evaluate the antibacterial activity of the aqueous, methanol and chloroform extracts of several plants available in Malaysia, namely Muntingia calabura (L.), Melastoma malabathricum (L.), Bauhinia purpurea (L.), Corchorus capsularis (L.) and Dicranopteris linearis (L.) using the single screening in vitro microtiter plate dilution methods. The extracts, at the dose of 5 μg μL-1, were screened against various strains of Staphylococcus aureus, namely S. aureus 29213α, S. aureus 33591, S. aureus 700699, vancomycin-intermediate S. aureus (VISA) and vancomycin-resistant S. aureus (VRSA). Results: Interestingly, only the methanol extracts of D. linearis exhibited an antibacterial activity against all strains of S. aureus whereas all extracts of M. calabura were effective only against the S. aureus 29213α, S. aureus 33591 and S. aureus 700699. The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) for D. linearis range between 0.625-1.250 and 1.250-2.500 μg μL-1, respectively whereas for the M. calabura extracts the MIC and MBC range between 1.250-5.000 and 2.500-5.000 μg μL-1, respectively. Although the other plants gave negative results in this study, their potential antibacterial properties should not be disregarded as the present study was carried out using only one low concentration (5 μg μL-1) and that the activity was determined using crude, but not pure, extracts. The present study demonstrated the potential of chloroform extract of D. linearis, which indicate the present of non-polar bioactive compounds, as VRSA antibacterial agents and all extracts of M. calabura as a potential source of antibacterial agents for the treatment of normal S. aureus infection.
  Z.A. Zakaria , N.I. Abdul Rahman , Y.W. Loo , A.H. Abdul Ayub , M.R. Sulaiman , A.M. Mat Jais , H.K. Gopalan and C.A. Fatimah
  Bauhinia purpurea L. (Leguminosae), has been used traditionally to treat ailments like sores, wounds and diarrhea. The present study was carried out to establish the antinociceptive and anti-inflammatory activities of chloroform extract of B. purpurea leaves using animal models. The air-dried, powdered leaves (≈ 20 g) were soaked in chloroform (1:20; w v-1) for 72 h and the supernatant obtained was then evaporated to dryness. The crude dried extract (≈ 1.323 g), dissolved in dimethyl sulfoxide, was prepared in the doses of 20, 100 and 200 mg kg-1 and then subjected to the respective antinociceptive (abdominal constriction, hot plate and formalin tests) and anti-inflammatory (carrageenan-induced paw edema test) assays. The results obtained indicate that the extract possess significant (p<0.05), but concentration-independent, antinociceptive activity when assessed using the abdominal constriction-and hot plate-test. This activity was also, significantly (p<0.05) observed in the early and late phases of the formalin test. The extract also exhibited significant (p<0.05) anti-inflammatory activity in a non-concentration-dependent manner. Unexpectedly, the 100 mg kg-1 extract showed a less remarkable anti-inflammatory activity compared to the other doses tested. The chloroform extract of B. purpurea contain bioactive compounds with potential peripheral and central antinociceptive and anti-inflammatory activities that requires further investigation.
  Z.A. Zakaria , A.M. Mat Jais , E.F.P. Henie , H. Zaiton , M.N. Somchit , M.R. Sulaiman and F.O. Faizal
  The present study was carried out to evaluate the potential of aqueous (AETT), ethanol (EETT) and chloroform (CETT) extracts of Tinosprora crispa as antibacterial agent against selected Gram positive (Bacillus cereus, Staphylococcus aureus, Listeria monocytogenes, Stretococcus pneumoniae and Clostridium diphtheriae) and Gram negative (Shigella flexneri, Salmonella typhi, Klebsiella pneumoniae, Proteus vulgaris and Escherichia coli) bacteria using the in vitro disc diffusion methods. Twenty microliter of the extracts, prepared in the concentrations of 25, 50, 74 and 100% (stock solution) by diluting the stock solution in distilled water (DH2O) or dimethyl sulfoxide (DMSO), were impregnated on sterilized blank discs (6 mm diameter) and tested against the respective bacteria. The AETT, at all concentrations, was effective only against S. pneumoniae and C. diphtheriae but show an activity against E. coli at the concentrations of 50% and above. At all concentrations used, the EETT was effective against S. aureus, S. pneumoniae, C. diphtheriae and S. flexneri while the CETT was effective against S. pneumoniae, C. diphtheriae and S. flexneri. Furthermore, the CETT, at the concentrations of 50% and above, was effective against E. coli. As a conclusion, T. crispa possesses potential antibacterial properties and further studies are being carried out to isolate and identify the responsible compound.
  Z.A. Zakaria , M.R. Sulaiman , A.K. Arifah , A.M. Mat Jais , M.N. Somchit , K. Kirisnaveni , D. Punnitharrani , M. Safarul , C.A. Fatimah and R. Johari
  The objective of this study was to elucidate the effects of C. olitorius as agent for relieving inflammation and fever. The aqueous extract of C. olitorius, in the concentration of 10, 50 and 100%, was used throughout the studies. The carrageenan-induced paw edema and brewer`s yeast-induced pyrexia assays were used as the anti-inflammatory and anti-pyretic assays, respectively. The extract, in the concentrations ranging from 50 to 100% and 10 to 100%, also exhibited significant (p<0.05) anti-inflammatory and anti-pyretic activities that lasted until the end of the experiments, respectively. In conclusion, the present studies provide scientific proof for the folklore medicinal used of C. olitorius as agent in the treatment of inflammation and fever.
  Z.A. Zakaria , R.N.S. Raden Mohd Nor , M.R. Sulaiman , Z.D.F. Abdul Ghani , G. Hanan Kumar and C.A. Fatimah
  The present study was carried out to establish the antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves chloroform extract in experimental animals. The antinociceptive activity was measured using the abdominal constriction, hot plate and formalin tests, while the anti-inflammatory was measured using the carrageenan-induced paw edema. The extract, obtained after 72 h soaking of the air-dried leaves in chloroform followed by evaporation under vacuo (40°C) to dryness (4.38 g), was dissolved in dimethyl sulfoxide to the doses of 20, 100 and 200% and administered subcutaneously 30 min prior to subjection to the above mentioned assays. The extract, at all concentration used, was found to exhibit significant (p<0.05) antinociceptive and anti-inflammatory activities. Only the effect observed with the formalin test occurred in a concentration-dependent manner. It is concluded that the lipid-soluble compounds within the chloroform extract of M. malabathricum leaves possess potential antinociceptive and anti-inflammatory agents that require further attention.
  Z.A. Zakaria , I. Reezal , A.M. Mat Jais , M.N. Somchit , M.R. Sulaiman , A.H.I. Marmin , H. Sidek , S.H. Husin , M.H.A. Rahim and L. Abdul Rahman
  The present study was carried out to evaluate the potential of C. nucifera as antipyretic, anti-inflammatory and wound healing agents. The fresh juice of C. nucifera (FJCN) was directly used while its aqueous kernel extract (AKCN) was obtained after 72 h soaking of 1:2 (w/v) fresh kernel in 2:1 (v/v) chloroform:methanol. The extracts, in the concentrations/strengths of 10, 50 and 100%, were used in the anti-pyretic and anti-inflammatory studies while those in the concentration of 100% were used only in the wound healing study. The fresh juice and aqueous kernel extract of C. nucifera exhibited significant (p<0.05) anti-inflammatory and antipyretic activities and promote wound healing with the latter producing a more effective effects in all assays used. This finding has scientifically supported the folkloric used of C. nucifera in the treatment of inflammation, pyrexia and wound.
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