Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the
coverage of the most important and influential journals
to meet the needs of the global scientific community.
This study was planned to determine the levels of uric
acid (UA) and CRP at preeclampsia and their association with the severity
of the disease. In a cross-sectional, case-control study we measured UA
and CRP levels in blood samples from 46 women with preeclampsia, 23 normal
pregnant women and 23 non pregnant women matched for age, BMI, parity
and gestational age were measured. Twenty three patients had developed
severe and 23 mild preeclampsia. UA and CRP were measured by enzymatic
method and enzyme-linked immunosorbent assay, respectively. Roc curve
was used to determine the optimal cutoff value. Results showed CRP and
UA concentrations were higher in Preeclamptic group (33.77 ±25.97,
5.93 ±0.75) compared with normal pregnant group (17.31 ±19.54,
5.47 ±0.41). CRP levels were also significantly elevated in women
with severe preeclampsia compared to those mild preeclampsia (42.26 ±24.04,
16.81 ±22.03). Determination of serum CRP levels may be used as
marker for the severity of preeclampsia. We also suggest that serum UA
level of 5.5 mg dL-1 is best cutoff point for the diagnosis
of preeclampsia.
