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by
M. Rajkumar |
Total Records (
2 ) for
M. Rajkumar |
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D. Senthil Rajan
,
M. Rajkumar
,
R. Srinivasan
,
R.P. Harikumar
,
S. Suresh
and
Senthil Kumar KL
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Seaweeds have been used by mankind as medicine and food for
more than 13,000 years. Marine algae are considered to produce a valuable phytoconstituents
characterized by a broad spectrum of antitumor activities. The aim of the present
study was to explore the effect of different solvent extracts of Sargassum
wightii, Greville against Dalton’s
Ascitic Lymphoma (DAL) in Swiss male albino mice. DAL cells were injected intraperitoneally
1x106 cell to the mice. Two days after cells injection the animals
were treated with different solvent extracts of Sargassum wightii at
dose of 200 mg kg-1 for 14 days. 5-fluorouracil (20 mg kg-1)
was used as reference drug. On day 11, cancer cell number, packed cell volume,
decrease in tumour weight of the mice, increase in life span and hematological
parameters were evaluated and compared with the same parameters in control.
A significant increase in the life span and a decrease in the cancer cell number
and tumour weight were noted in the tumour-induced mice after treatment with
the extract. The haematological parameters were also normalized by the ethanolic
and chloroform extracts in tumour-induced mice. These observations are suggestive
of the protective effect of ethanolic extract of Sargassum wightii is
comparatively better than other two tested extracts against Dalton’s
Ascitic Lymphoma (DAL). |
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M. Rajkumar
,
R. Thavasi
,
P. Perumal
and
Jean-Paul Trilles
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The attempt of the present study is to achieve an approach of the magnitude of parasite induced secondary infection estimation of Vibrio, Salmonella and Pseudomonas loads as well as the total heterotrophic bacteria using a battery of biochemical tests. The parasitic isopod Nerocila phaiopleura was collected from commonly available fish Stolephorus commersonii at Parangipettai, India. Parasites settled on the branchial and external body surface of the fish causes red coloured skin lesions, where secondary bacterial infections were detected. THB and Vibrio counts were higher in the infected hosts than in the healthy fish and it was found to 7.2x105 and 3.5x103 cfu g-1 in branchial regions and 5.4x105 and 2.3x103 cfu g-1 in the body surfaces, respectively. Salmonella counts were found as 6.0x103 and 3.6x101 cfu g-1 in branchial regions of the infected and uninfected fish and in body regions, 3.9x103 and 1.03x102 cfu g-1, respectively. Pseudomonas counts were 7.0x102, 4.9x101 cfu g-1 in branchial regions and 6.2x102, 5.8x101 cfu g-1 in the body surfaces of the infected and uninfected fish. Statistical analysis of the results (t-test) showed high significant value (p<0.05). |
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