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Articles by M. Ozaslan
Total Records ( 9 ) for M. Ozaslan
  Muhammet E. Guldur , A. Ozgonul , Ibrahim H. Kilic , O. Sogut , M. Ozaslan , M. Bitiren , M. Yalcin and D. Musa
  Cyperus rotundus (CR) is widely used as a traditional folk medicine for treating various diseases such as gastrointestinal disorders, inflammatory and infectious diseases in Middle Eastern countries. However, the protective effects of CR extract on gastric mucosa has not been well defined. Thus, the aim of the present study was to investigate the protective effects of CR on gastric mucosal damage induced by ischemia and reperfusion in rats. Ischemia/reperfusion model was designed as of 30 min ischemia followed with 60 min reperfusion by clamping the celiac artery. The CR extracts were given at the doses of 100 or 200 mg kg-1 for preventing postischemic gastric mucosal injury. The study was carried out on equal five groups (n = 6) namely as follows: group I (sham, control group), group II (untreated ischemia control group), group III (treated ischemia group) was treated with 200 mg kg-1 CR, group IV (treated ischemia group) was treated with 100 mg kg-1 CR and group V (treated ischemia/reperfusion group) was treated with 200 mg kg-1 CR. Antioxidant enzymes activity such as Malondialdehyde (MDA) and glutathione-peroxidase (GSH-Px) were measured in the gastric tissue. Histopathological sections were examined for ischemic injury. The mean ulcer index of rats treated with 200 and 100 mg kg-1 CR were significantly lower (p<0.05) than that of control rats. The activities of GSH-Px and MDA were significantly affected (p<0.05) by treatment of CR in group III and group IV. These results indicate that both doses of CR extract have gastroprotective effect against acute gastric mucosal lesions induced by ischemia/reperfusion.
  M. Bitiren , D. Musa , A. Ozgonul , M. Ozaslan , A. Kocyigit , O. Sogut , Muhammet E. Guldur , I.H. Kilic , Ali Z. Karakilcik and M. Zerin
  The present study was planned to investigate the protective effects of herbal methanol extracts of Hypericum perforatum (HP) and Urtica dioica (UD) and herbal agueous extract of Camelia sinensis (CS)-containing antioxidants on carbon tetrachloride (CCl4)-induced hepatic injury and lymphocyte DNA damage. Adult male albino rats (n 50) were separated into five groups of ten each, as follows: control group; CCl4 group; CCl4+HP extract group; CCl4+UD extract group; CCl4+CS extract group. All extract groups were fed with 200 mg kg-1 extracts of HP, CS and UD, respectively once every alternate day for 7 weeks. CCl4 injections were applied to the CCl4 and extract groups at the dose of 0.4 mL kg-1. Malondialdehyde, total oxidant status and total antioxidative capacity levels and catalase, superoxide dismutase and glutathione peroxidase activities were significantly changed in the CCl4 group and indicated increased oxidative stress. The DNA damages detected via commet assay were significantly higher than in the CCl4 group. Treatment by extracts of HP, CS or UD were significantly decreased this oxidative stress and ameliorated lymphocyte DNA damage. These results indicate that the herbal extracts of HP, UC and CS have beneficial effects on liver and lymphocyte DNA damage induced by CCl4 probably due to their antioxidant properties.
  I. Halil Kilic , M. Meltem Koruk , M. Ozaslan , I. Didem Karagoz , Yasemin Zer , Mehmet Koruk , Ceyda Uyar and Izzettin Guler
  The majority of hepatitis C virus (HCV) isolates are resistant to antiviral therapy. Although, the molecular mechanisms of resistance against to antiviral therapy were investigated in such studies in vivo and/or in vitro and the significant results were obtained, the resistance problem has not been solved yet. The aim of this study was to investigate the relationship between therapy and response by detecting the mutations in ISDR2209-2248 and PKR-BD2209-2274 site among HCV positive patients in Gaziantep. Fifty nine patients (25 men and 34 women) with chronic hepatitis C diagnosed at Gastroenterology Department of Gaziantep University Sahinbey Research Hospital between 2009-2010 years were included. The 59 HCV RNA positive patients: 34 women and 25 men were included. In ISDR2209-2248 site in PKR-BD2209-2274 site, 25 of 89 amino-acid substitutions (28.09%) of the sustained virologic responder patients; 12 of 78 amino-acid substitutions (15.38%) in the non-responder patients were determined. The significant relation between the number of mutation in interferon sensitivity determining region- ISDR2209-2248 and protein kinase binding domain- PKR-BD2209-2274 of NS5A gene and the response to interferon-alpha+ribavirin combination therapy was not determined (p>0.05). The number of mutation in this region was not significant in predicting the response of chronic hepatitis C patients to the treatment. The evaluation of age, individual immunization, nutritional situations, psychological situation of people infected with HCV and other gene regions would be useful.
  I.D. Karagoz , M. Ozaslan , I. Guler , C. Uyar , T. Yalim , U. Kazanci , A. Aslan and A. Cakir
  Lichens synthesize very special metabolites as differ from other plant species. Usnea longissima, which is usually spread in moist and shady areas, is a lichen species. Usnea longissima has many biological activities. Diffractaic acid is one of the major metabolites of Usnea species. The present study aimed to investigate the anticancer efficacy of a lichen metabolite, diffractaic acid, on experimentally induced in vivo Ehrlich ascites carcinoma. Diffractaic acid was isolated and its chemical structure was confirmed by UV, IR, 1H-NMR, 13C-NMR, 1D and 2D-NMR spectroscopic methods. A total of 50 Balb/C male mice were divided into 5 groups (n:10). About 1x106 carcinoma cells were inoculated intraperitonally to the animals and after 2 days 50-200 mg kg-1 diffractaic acid were given for 13 days. Heamatological parameters were measured from serum samples. The EAC fluid was collected by paracentesis and the cells were counted according to trypan blue dye exclusion method. Stomach, liver, kidney and small and large intestine tissues were examined histopathologically. Diffractaic acid showed the antitumor effect on EAC cells and histopathological and haematological studies showed lower doses of diffractaic acid has protective effect as compared with its higher doses.
  M. Ozaslan , I.D. Karagoz , R.A. Lawal , I.H. Kilic , A. Cakir , O.S. Odesanmi , I. Guler and O.A.T. Ebuehi
  Background: Tetrapleura tetraptera fruit is widely used in Southern Nigeria for a range of pharmacological actions. Methodology/Principal Findings: In this study, the cytotoxic and antiproliferative effects of the ethanolic extract of fruit were studied in vitro and in vivo by using ehrlich ascites carcinoma cells and tumor modelling, respectively. Cytotoxic activity was determined by incubating the ehrlich ascites carcinoma cells with 0.1, 1, 10 and 100 μg mL–1 of the extract. In vivo study, 20, 40 and 80 mg kg–1 b.wt., doses of the extract was inoculated by intraperitoneal administration to mice following to carcinoma cells inoculation by same way. The extract was cytotoxic to carcinoma cells as assessed by both in vitro and in vivo experiments. Conclusion/Significance: The IC50 of the extract was found to be 250 μg mL–1. Results showed that the Tetrapleura tetraptera increased the life span of mice via reducing the number of the viable EAC cells, decreasing in ascites fluid volume and tumor burden. The DNA fragmentation assay also showed that it has a possible pro-apoptotic effect.
  N. Hallal , O. Kharoubi , I. Benyettou , K. Tair , M. Ozaslan and A.E.K. Aoues
  Background and Objective: Artemisia absinthium L. has long been used as traditional herbal medicine for the treatment of gastric pain, cardiac stimulation to improve memory and to restore declining mental function. Aim of the present study was designed to investigate the effects of Artemisia absinthium L. on cerebral oxidative stress induced by mercury. Aqueous extract (AEAA) (500 mg L–1 b.wt. day–1) was administered orally to experimental rat and brain injury was induced by administration of HgCl2 (5 mg kg–1 b.wt., i.p.). Methodology: The activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), Glutathione Reductase (GR), catalase (CAT) and thioredoxin reductase (TrxR) were measured in different brain regions: Cerebral cortex (CX), cerebellum (CE), hippocumpus (HI) and striatum (ST). Lipid peroxidation (LPO) and Protein Oxidation (PO) levels were determined by evaluated the levels of malondialdehyde (MDA) and Protein Carbonyl (PC). Results: Lipid peroxidation was significantly higher in all brain regions vs. control after HgCl2 treatment. In CX and HI, it is observed a significant depletion of activities, respectively in glutathione peroxydase (11 and 81%), glutathione reductase (32 and 15%), superoxide dismutase (98 and 77%) and catalase (18 and 44%). Further, thioredoxine system was also significantly impaired by mercury as compared with control group. Conclusion: Obtained results demonstrated that treatment with AEAA reduce significantly (p<0.001) MDA level by 26.99, 31.81 and 80.70% in CE, CX and ST, respectively and increase catalase activity in CE. Furthermore, AEAA significantly (p<0.001) restored activities of defense antioxidant enzymes SOD and GPx, GR and TrxR towards normal levels in brain regions.
  I.H. Kilic , M. Ozaslan , T. Karsligil , I.D. Karagoz and Y. Zer
  Pathogens causing summer diarrhea examined to detect among children less than 5 years of age in Gaziantep. We conducted among 100 children with diarrhea during summer at the pediatric hospital of Gaziantep. In stool samples from children, Rotavirus with Rotatect kit (Dade Behring, Germany), Entamoeba spp. with direct microscopy and bacterial pathogens with cultural techniques investigated. Cystic form of Entamoeba spp. was determined in 61 (61%) and Rotavirus antigen in 25 positive samples (25%). A predominant bacterium was determined in total 87 stool samples (87%). Despite of only cystic form of Entamoeba spp. was determined in seven, only bacteria in 22 and only Rotavirus in one; two of them were determined in 67 out of stool samples. According to comparison with stool samples belong to various months we have found that, Rotavirus and E. coli are the most pathogenic agents in August more than June and July.
  I.H. Kilic , M. Ozaslan , I.D. Karagoz , Y. Zer and V. Davutoglu
  Mobile phones are dispensable accessories in social life and normally they are not cleaned properly. Therefore, they serve as a reservoir of bacteria and may cause nosocomial infections in hospitals. The purpose of this study was to investigate microbiological colonization of mobile phones used by healthcare staffs. The study was carried out collecting swab samples with Cary-Blair transport medium from mobile phones of attending healthcare staffs from different departments of three hospitals in March, 2008. All collected samples were inoculated in 5% sheep blood agar, eosin-methylene blue agar and Sabouraud Dextrose agar. Isolated bacteria were identified using by classic technique and Vitec2 (Biomerieux, France) full automated bacteria identification system. Growth was observed in 65 of collected 106 samples, corresponding to 61.3%. The most frequent bacteria were Staphylococcus epidermidis followed by Staphylococcus aureus, Bacillus sp., Corynebacterium sp. and Escherichia coli, respectively. In conclusion, bacteria were colonized on mobile phones frequently and mobile phones may become reservoir of microorganism for nosocomial infections.
  M.E Guldur , M. Ozaslan , T. Aytekin , I.H. Kilic and I.D. Afacan
  The ability of zinc to retard oxidants and to be antioxidant has been recognized for many years. In the present study, it is aimed to determine histological toxic effects of zinc supplementation on hepatic tissue. It was also planned to determine effect of zinc on TAL. In this study, 24 male Wistar albino rats were used. All animals were divided 4 groups; 1 control, 3 experimental group. Three milliliter (227 mg L-1 day-1) zinc-sulphate was treated in experimental groups during 15, 30 and 45 days, respectively. TAL, AST and ALT levels from collected cardiac blood samples (3 mL) were measured. For histological investigation, liver tissue was removed and stained with Haematoxilen-eosin. It was determined that, TAL reduced in group I which was given zinc during 15 days and TAL increased in group II and Group III which was given zinc 30 and 45 days, respectively compared to that of group control. Results of the histological investigation showed that no toxicity in even experimental groups.
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