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The research work was conducted to investigated the in vitro antibacterial activity
of the compound isolated from Trapa bispinosa. Antibacterial activity of the
compounds was observed against fifteen pathogenic organisms (both Gram
positive and Gram negative Bacteria) by disc diffusion method. Compound MTC-4 isolated from chloroform extract showed significant in vitro antibacterial
activity against almost all of the test organisms but maximum activity showed
against Bacillus subtilis and shigella dysenteriae and produced zone of
inhibition in between 12 to 15mm. While the compound MTE-1 showed
moderate activity (08 to 12mm) against most of the test organisms. The other two
compounds MTC-3 and MTC-5 were found comparatively less active. The MIC
values of the compounds were also determined against two test organisms
Bacillus subtilis and Shigella dysenteriae. The values were found to be between 8
to 128μg ml‾1. Thus MTC-4 possesses strong antibacterial activity and suggested
its therapeutic use as an antimicrobial agent.
