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Articles by M. Hasan
Total Records ( 2 ) for M. Hasan
  M. Habibur Rahman , M. Badrul Alam , N.S. Chowdhury , M.K. Jha , M. Hasan , M.M. Khan , M.S. Rahman and M. Ekramul Haque
  In the present study crude methanolic extract of Stephania japonica leaf was investigated for possible antioxidant, analgesic and toxic activity. The extract showed antioxidant activity in DPPH radical scavenging activity, nitric oxide scavenging activity and reducing power assays. In both DPPH radical and NO scavenging assay, the extract exhibited moderate antioxidant activity and the IC50 values in DPPH radical scavenging and NO scavenging assays were found to be 105.55±1.06 and 129.12±0.15 μg mL-1, respectively while the IC50 values of ascorbic acid were 12.30±0.11 and 18.64±0.22 μg mL-1, respectively. Reducing power activity of the extract increased in a dose dependent manner. Analgesic activity of the crude extract was evaluated using acetic acid-induced writhing model of pain in mice. The crude extract at 200 and 400 mg kg-1 b.wt. doses displayed significant (p<0.001) reduction in acetic acid induced writhing in mice with a maximum effect of 75.89% reduction at 400 mg kg-1 b.wt. which is comparable to the standard, diclofenac sodium (86.52%). The extract was also investigated for toxic potentiality using Brine Shrimp lethality bioassay. In this bioassay the extract showed significant toxicity to Brine Shrimp nauplii with the LC50 value of 25.19±0.98 μg mL-1. The study clearly indicates that the extract possesses good analgesic and cytotoxic activity along with moderate antioxidant potential.
  M. Badrul Alam , M. Saifur Rahman , M. Hasan , M. Maruf Khan , Kamrun Nahar and Sheema Sultana
  Dillenia indica Linn. (Dilleniaceae) is widely used as food and reputed in the folk medicine of Bangladesh and India in particular, to relieve pain associated with gastrointestinal disturbance. Methanolic extract of the bark of Dillenia indica Linn. (MDI) was subjected to evaluate for its analgesic and antioxidant properties. The analgesic activity of MDI (200 and 400 mg kg-1 b.wt. p.o.) was determined for its central and peripheral pharmacological actions using hotplate as well as tail immersion method and acetic acid-induced writhing test with formalin induced pain in mice, respectively. To evaluate antioxidant potential of MDI, total antioxidant activity, scavenging of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical as well as total Reactive Oxygen Species (ROS) and assessment of reducing power were used. The extract, at the dose of 200 and 400 mg kg-1, produced a significant (p<0.05) increase in pain threshold in hotplate and tail immersion methods whereas significantly (p<0.05) reduced the writhing caused by acetic acid and the number of licks induced by formalin in a dose dependent manner. In DPPH and total ROS scavenging method, MDI showed good antioxidant potentiality with the IC50 value of 12.32±0.16 and 34.72±0.48 μg mL-1, respectively with a good reducing power. The findings of the study suggested that MDI has strong analgesic and antioxidant effects, conforming the traditional use of this plant for pain alleviation to its antioxidant potentiality.
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