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Articles by M. Dhanalakshmi
Total Records ( 3 ) for M. Dhanalakshmi
  S. Nirmala Devi , M. Dhanalakshmi and N. Kumaravel
  We propose a method for segmentation of vascular structures and determination of blood flow velocity in coronary angiograms. The angiogram images of normal and abnormal-collateral patients are acquired at a rate of 15 frames/sec. In each frame, blood vessel is segmented from background using a backpropagation network. The input is given to two network topologies (121-17-2 and 4-3-2 layer configuration) and tested for their performance. The 4-3-2 configuration was able to classify blood vessel with less number of iterations comparatively and it can detect even small vessels with less computation time. The blood flow velocity in angiogram is determined in two methods. First method is by measuring the distance traversed by the contrast agent in each frame. The second method is based on determining the change in concentration of the contrast agent in two fixed region of interest. By first method, the flow velocity for normal and collateral angiograms are found to be 38 pixels/frame(p/f) and 15 p/f, respectively and by the second method, it is calculated as 45 and 28 p/f, respectively. The results show delayed arrival of contrast in abnormal collaterals than in normal images.
  S. Kameshwaran , C. Jothimanivannan , R. Senthilkumar , S. Thenmozhi , R. Sundaraganapathy and M. Dhanalakshmi
  Objective: Diarrhea is one of the widespread wellbeing situation upsetting people in less developed countries. This study was done to appraise anti-diarrheal influence of the ethanolic flower extract of Tecoma stans (EETS) using Wistar albino rats to determine the acute toxicity in mice. Material and Methods: The flowers were collected and extracted with 70% ethanol. The dry extract was reconstituted using normal saline for the oral administration to diverse groups of rats at doses of 200, 400 and 600 mg kg-1. Anti-diarrheal activity was resulted using the percentage fall in the incidence of defecation in rats with castor oil-induced diarrhea. Loperamide (1 mg kg-1) was worn as positive control. Acute toxicity was evaluated by fortitude of LD50 and observations of toxic signs. Results: EETS showed momentous (p<0.05) antidiarrheal activity evidenced by the lessening in rate of defecation by up to 78.33% at 600 mg kg-1 b.wt. analogous to loperamide (100%). This activity could be accredited to the phytochemicals such as flavonoids and tannins in Tecoma stans that were present in high levels and have been reported to demonstrate antidiarrheal activity through denaturing protein hence forming protein tannates which curtail the intestinal mucosa permeability. The LD50 of the crude EETS was 10,715 mg kg-1. Conclusion: The findings of this study illustrate that the flower of Tecoma stans have a very significant antidiarrheal commotion and are not dangerous to use as indicated by the high LD50 value. This ropes the conventional use of the EETS as herbal therapy for treatment of diarrhea.
  S. Kameshwaran , R. Senthilkumar , S. Thenmozhi and M. Dhanalakshmi
  Background: The entire wound healing process is a complex series of events that begins at the moment of injury and can continue for months to years. The stages of wound healing are inflammatory phase, proliferation phase, fibroblastic phase and maturation phase. The present study provides a précised valuation for the wound healing potential of ethanolic extract of Tecoma stans (EETS). Materials and Methods: Excision, incision and burn wounds were inflicted upon three groups of six rats each. Group I was assigned as control (ointment base). Group II was treated with 10% ethanolic extract of Tecoma stans (EETS) ointment. Group III was treated with standard silver sulfadiazine (0.01%) cream. The parameters observed were percentage of wound contraction, epithelialization period, hydroxyproline content, tensile strength including histopathological studies. Results: Result showed that the EETS ointment showed significant (p<0.01) healing in all wound models when compared with the control group. All parameters such as wound contraction, epithelialization period, hydroxyproline content, tensile strength and histopathological studies showed considerable (p<0.01) changes when compared with the control. Conclusion: Finally, it was accomplished that the EETS ointment efficiently stimulates wound contraction; increases tensile strength of excision, incision and burn wounds.
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