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by
M. Bali |
Total Records (
10 ) for
M. Bali |
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N.S. Gill
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J. Bajwa
,
K. Dhiman
,
P. Sharma
,
S. Sood
,
P.D. Sharma
,
B. Singh
and
M. Bali
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The objective of present study was to evaluate the therapeutic potential of Cucumis melo seeds traditionally consumed and it was studied for free radical scavenging potential by hydrogen peroxide (H2O2) and DPPH method. Anti-inflammatory activity was evaluated using carrageenan-induced paw edema in rats. Analgesic activity was evaluated by tail immersion and tail flick methods in mice. The percentage scavenging of DPPH radical and H2O2 radical was 74.9% at 300 μg mL-1 and 58.91% at 200 μg mL-1 respectively concentration of. The H2O2 scavenging effect of MECM was 58.91%. The percentage reduction of paw edema was 56.6% at the dose of 300 mg kg-1. The high dose caused significant reduction in pain. Thus it can be concluded from the above results that Cucumis melo seeds have potent anti-inflammatory, antioxidant and analgesic activity. |
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N.S. Gill
,
Nistha Marwah
,
Rashmi Arora
and
M. Bali
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The present study was to investigate antioxidant, analgesic
and antiulcer effect of ethanolic seeds extract of Trichosanthes cucumerina.
Extraction was done by cold maceration method for 72 h using ethanol as solvent.
The preliminary phytochemical screening showed the presence of triterpenoids,
flavanoids and sterols. The antioxidant activity was determined by 1,1-diphenyl-2-picrylhydrazyl
(DPPH) radical scavenging method. The extract showed maximum scavenging activity
86.2% at 150 μg mL-1 by DPPH method as compared to standard
antioxidant ascorbic acid. Further extract was studied for antiulcer activity
by ethanol induced ulcer model and Non steroidal anti-inflammatory drugs induced
method and analgesic activity by Eddy’s
hot plate method. Ethanolic extract of Trichosanthes cucumerina cause
72.1 and 57.1% inhibition of ulcer in Non steroidal anti-inflammatory drugs
induced model and ethanol induced model at 500 mg kg-1. Result concluded
that Ethanolic extract of Trichosanthes cucumerina possess high antiulcer
activity which is due to high antioxidant activity and extract also showed potential
analgesic activity by Eddy’s
hot plate method. |
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S. Sood
,
A. Muthuraman
,
N.S. Gill
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M. Bali
and
P.D. Sharma
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The present study was designed to evaluate the antioxidant and anti-ulcerogenic potential of Citrus karna peel extract. Extraction of Citrus karna peels was carried out using different solvents. Phytochemical screening and evaluation of antioxidant activity of all the extracts were carried out. Further, anti-ulcerogenic activity of ethyl acetate extract of Citrus karna peels (EtCK) was assessed in water immersion (WIS) and hypothermic restraint (HRS) stress models at different doses (200, 300 and 400 mg kg-1). EtCK showed ulcer protective effect in both models in a dose dependent manner, which was indicated by decrease in the ulcerative index and thiobarbituric acid reactive species (TBARS) level in the blood and gastric tissue samples as compared to the disease control group. Moreover, antioxidant markers i.e., reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) in the blood and tissue samples were found to be significantly increased in medium and high doses of EtCK (300 and 400 mg kg-1) treated groups similar to that of ranitidine treated group. The present study concluded that EtCK has a significant anti-ulcer effect at a dose level of 300 and 400 mg kg-1. Hence, it may be considered as a useful herbal therapeutic agent for the treatment of peptic ulcer disease. |
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N.S. Gill
,
S. Singh
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R. Arora
and
M. Bali
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During the past few decades, the drugs from natural products have gained importance
in the field of medicine. Many plants and their products exhibit marked pharmacological
activities. Lagenaria siceraria fruit is one of the important natural
plant which is used in the treatment of various disorders. The present study
was designed to investigate the antioxidant, anti-inflammatory and analgesic
potential of ethanolic extract of Lagenaria siceraria seeds. The Lagenaria
siceraria seeds were evaluated for their antioxidant potential by 1,1-diphenyl-2-picrylhydrazyl
method. The extract showed significant antioxidant potential in a dose dependent
manner as compared to ascorbic acid. The extract showed maximum scavenging activity
i.e., 75.19% at 200 μg by 1,1-diphenyl-2-picrylhydrazyl free radical scavenging
method. Thus, it was further studied for anti-inflammatory activity by Carrageenan
induced rat paw edema and analgesic activity by Tail immersion method and Hot
plate method at different concentrations i.e., 100, 200 and 300 mg kg-1.
The results showed that ethanolic extract of Lagenaria siceraria seeds
possess good therapeutic potential and may be useful as a natural antioxidant
and it can be used in the treatment of inflammation and pain. |
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N.S. Gill
,
J. Bajwa
,
P. Sharma
,
K. Dhiman
,
S. Sood
,
P.D. Sharma
,
B. Singh
and
M. Bali
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The present study was to investigate the anti-ulcer activity of methanolic extract of Cucumis melo (MECM) seeds. The seeds were extracted with methanol and the extract was evaluated for its free radical scavenging activity by DPPH. It shows maximum antioxidant activity. Thus extract was further evaluated against gastric ulcerations by Pyloric Ligation (PL), Water Immersion Stress (WIS) and NSAID (indomethacin) induced ulcer (NIU) models. In case of PL method, the extract inhibited gastric ulcerations in a dose-related manner (150 and 300 mg kg-1). Then it was evaluated for gastric volume, free acidity, total acidity, ulcerative index. The ulcerative index was also measured in WIS model and NIU with same doses. The MECM caused 57.6, 67.6 and 61.9% inhibition of ulcers in pyloric ligation, water immersion stress, NSAID induced ulcer models respectively at 300 mg kg-1. The results concluded that MECM possess high antiulcer potential which is due to its higher antioxidant activity. |
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N.S. Gill
,
P. Sharma
,
J. Bajwa
,
K. Dhiman
,
S. Sood
,
P.D. Sharma
and
M. Bali
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The present study was designed to investigate Cucumis melo var. utilissimus seeds for their antioxidant and therapeutic potential. The antioxidant activity of methanolic extract was measured by DPPH method and hydrogen peroxide free radical scavenging activity. The methanolic extract of Cucumis melo var. utilissimus seeds (MECU) showed maximum antioxidant potential. Hence, it was further evaluated for anti-inflammatory activity by carrageenan induced rat paw edema and analgesic activity by tail immersion method and tail flick method at different concentrations, i.e., 100, 200 and 300 mg kg-1. The significant results was found at maximum dose. The results suggested that methanolic seed extract possess great therapeutic potential. |
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N.S. Gill
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R. Sharma
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R. Arora
and
M. Bali
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The present study was carried out to evaluate the antioxidant and antibacterial activity of methanolic leaf extract of Hippophae rhamnoides L. (Sea buckthorn, SBT) leaves under in vitro conditions. The chemical composition of the methanolic leaf extract was quantified in terms of total phenol and flavonoid contents. The Hippophae rhamnoides methanolic leaf extract exhibited potent antioxidant activity determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and then by 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), assays. The scavenging capacity by DPPH and ABTS of the extracts was found to increase with every unit increase of Hippophae rhamnoides leaf extracts reaching 68% at 30 μg mL-1 concentration. Further, the extract was evaluated for antibacterial activity against three human pathogenic bacteria E. coli, A. protophormial and M. luteus, however, it was maximum against E. coli. The study shows that the methanolic extract of Hippophae rhamnoides leaves have marked antioxidant and antibacterial activities. |
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S. Sood
,
S. Bansal
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A. Muthuraman
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N.S. Gill
and
M. Bali
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In this study, we planned to evaluate the antioxidative, anti-inflammatory and analgesic potential of Citrus medica peel extract. Antioxidant activity in different solvent systems was evaluated. Ethyl acetate extract of Citrus medica peel (EtCM) showed maximum 1,1-diphenyl-2-picrylhydrazyl (DPPH) and hydrogen peroxide radical scavenging activity in a dose dependent manner as compared to ascorbic acid. Further, anti-inflammatory and analgesic activities of EtCM (200, 300 and 400 mg kg-1) were studied on carrageenan induced inflammatory pain in rats. Anti-inflammatory activity was assessed by measuring paw volume in rats. Analgesic activity was evaluated for its central and peripheral pharmacological actions by using hot plate, plantar, pin prick and mechanical allodynia tests in rats. EtCM (400 mg kg-1) produced significant decrease in paw volume and pain as compared to diclofenac. Therefore, the Citrus medica peel extract may be used as a future antioxidant for the treatment of inflammation and pain. |
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N.S. Gill
,
K. Dhiman
,
P. Sharma
,
J. Bajwa
,
S. Sood
,
P.D. Sharma
,
B. Singh
and
M. Bali
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In the present study free radical scavenging and antiulcer potential of Benincasa hispida seeds was evaluated. The powdered seeds were extracted with methanol. The extract was evaluated for its free radical scavenging activity by DPPH method followed by antiulcer activity using pyloric ligation, water immersion stress and NSAID (indomethacin) induced gastric ulcer model (NIU) in rats. The parameters assessed were gastric volume, free acidity, total acidity, ulcer index and percentage ulcer protection. Ranitidine was used as the reference antiulcer drug. The methanolic extract showed concentration dependent DPPH radical scavenging activity. The methanolic extract of Benincasa hispida seeds (MEBH) inhibited gastric ulceration by decreasing the gastric volume, free and total acidity. The high dose (300 mg kg-1) showed significant reduction in the above parameters which was comparable to the standard drug ranitidine (p<0.05). The MEBH caused 52.7, 67.4 and 61.2% inhibition of ulcers in pyloric ligation, water immersion stress and NSAID induced ulcer models, respectively at 300 mg kg-1. Thus it can be concluded that the seeds of Benincasa hispida possess potent antiulcer activity. The antiulcer action may be exerted through free radical scavenging mechanism. |
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N.S. Gill
,
S. Dhawan
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A. Jain
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R. Arora
and
M. Bali
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These seeds have been traditionally used for various diseases like dysentery, diarrhoea, piles, keeping in mind of their traditional value our present study was to explore wild Punica granatum seeds for its antioxidant and antiulcer potential. The phytochemical screening of the ethanolic seed extract indicates the presence of triterpenoid, sterols, alkaloids, flavonoids, tannins and coumarin glycoside. Antioxidant activity of the wild Punica granatum ethanolic seed extract was measured by 1,1-diphenyl-2-picrylhydrazyl and hydrogen peroxide free radical scavenging method. Further it was evaluated for its anti-ulcer activity by pyloric ligation model in wistar albino rats. Gastric volume, ulcerative index and free and total acidity were measured in this model. The extract showed maximum scavenging activity i.e., 82.80±0.267 and 74.91±0.235 at 100 μg mL-1 by 1,1-diphenyl-2-picrylhydrazyl and hydrogen peroxide method respectively as compared to the standard (ascorbic acid) in case of quantitative analysis and showed yellow coloration with 1,1-diphenyl-2-picrylhydrazyl scavenging radical in case of qualitative analysis. In pyloric ligation method, the extract showed optimum percentage inhibition of 74.51% at 100 μg mL-1 which was comparable to the standard (ranitidine). The present study concludes that wild Punica granatum ethanolic seed extract possesses significant antioxidant and anti-ulcer activities. |
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