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Articles by M. Abdollahi
Total Records ( 14 ) for M. Abdollahi
  G. Saki , M. Hashemitabar , M. Abdollahi and S.H. Razie
  The aim of this study was to evaluate the effects of Vero cells on early embryonic cleavage rate and overcome cellblock of mice embryos in vitro. Female mice were super-ovulated by Intra-peritoneal injection of 5 IU Pregnant mare serum gonadotropine (PMSG) and 5 IU Human Chorionic Gonadotropine (HCG) 48 h later. The super-ovulated female NMRI mice placed individually with NMRI (Noda Medical Research Institute) males of proved fertility. The following morning, the females with positive vaginal plug were killed and cumulus-enclosed single cell embryos (2PN) were recovered. Two pronuclear (n=170) embryos were divided randomly into 2 groups: (1) co culture with vero cells (2) culture in simple culture medium. The rate of the development and the morphological appearance of mouse embryos in two groups were recorded daily for 120 h after retrieval in each system using inverted microscope. On day 5 of development the results showed that embryos cultured on vero cells had a significantly higher blastocyst and hatching formation rate than those in simple culture medium alone (p<0.05). It is concluded that Vero cells may improve mouse embryo development partly by increasing blastocyst formation, hatching blastocyst rate.
  H.R. Rahimi , M. Gholami , H.R. Khorram-Khorshid , F. Gharibdoost and M. Abdollahi
  Hepatoprotective effect and mechanisms of a novel selenium/electromagnetically treated multiherbal mixture named Setarud (IMODTM) in combination with silymarin (SM) a known hepatoprotective compound was investigated in acetaminophen-induced acute hepatic failure rat model. Animals were divided into five groups and pre-induced with phenobarbital (0.1 mg kg-1, i.p.) before administration of a single dose of acetaminophen (1 g kg-1, i.p.) except group 1 which was considered as normal. Group 2 was remained without treatment and considered as control while groups 3 to 5 were treated with SM (50 mg kg-1, p.o.), IMOD (30 mg kg-1, i.p.) and IMOD+SM, respectively 24 h post administration of acetaminophen. Blood was collected at 0, 24 and 72 h post acetaminophen treatment. Elevated serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) confirmed hepatic failure induced by acetaminophen. After 48 h of treatment, the rats were anesthetized and the liver was removed and the right lobule was homogenized and then measured for catalase (CAT), malondialdehyde (MDA) and glutathione (GSH) value. Part of liver was left in paraffin for histopathology examination. CAT and GSH were significantly decreased in the acetaminophen-treated group while ALT, AST, ALP and MDA increased when compared to normals. Histopathological examination of acetaminophen-treated animals showed necrosis, inflammation, hyperplasia of kupffer and infiltration of mononuclear cells, dilation of sinusoids and disruption of hepatocytes, while treatment with IMOD+SM normalized protected hepatic architecture in accordance to biochemical results. Treatment of animals with IMOD and SM alone or in combinations considerably protected the hepatic failure by diminishing ALT, AST, ALP and MDA. Both IMOD and SM and their combination improved acetaminophen-induced histopathological hepatic damage. Conclusion is that combination of IMOD and SM considerably protect from acute hepatic failure via enzymatic and non-enzymatic mechanisms.
  S. Nikfar , R. Rahimi and M. Abdollahi
  Interferon beta (IFNβ) an immunomodulatory agent has been approved for Multiple Sclerosis (MS) patients with a relapsing course. The aim of this meta-analysis was to compare three different formulations of IFNβ including intramuscular IFNβ-1a (Avonex®), subcutaneous IFNβ-1a (Rebif®) and subcutaneous IFNβ-1b (Betaseron or Betaferon) in Relapsing Remitting MS (RRMS). Pubmed, Scopus and Cochrane Central Register of controlled trials were searched for studies comparing efficacy of different formulations of IFNβ in RRMS. Data were collected from 1966 to 2009 (up to July). Mean change in Expanded Disability Status Scale (EDSS) and number of patients with at least one relapse were the key outcomes of interest for assessment of efficacy. Six studies met our criteria and were included. Comparison of Avonex with Rebif yielded a non-significant Relative Risk (RR) of 0.85 (95% CI of 0.57-1.25, p = 0.3954). A non-significant RR of 0.91 (95% CI of 0.75-1.10, p = 0.3378) was obtained when Avonex compared with Betaferon. Comparison of Rebif with Betaferon yielded a significant RR of 0.9 (95% CI of 0.82-1, p = 0.0481). Although, not statistically significant, Rebif or Betaferon work better than Avonex whereas Betaferon was even better than Rebif in management of RRMS.
  P. Salari Sharif and M. Abdollahi
  Nowadays β-blockers are commonly used for a broad spectrum of diseases including cardiovascular diseases but their effects on the bone are an issue of concern. Animal studies support their protective effects on bone however, human studies are controversial. We followed this issue by conducting a systematic review of all existing materials through all available search engines. Results indicate a major controversy existing among studies. Most of studies are limited to lack of considering pharmacokinetic/pharmacodynamic properties of this class of drugs, Body Mass Index (BMI) as well as physical activity of patients, adequacy of sample size or ability to sub-analyze data, smoking behavior and patients’ lifestyle that all can be a source of bias and cause controversy. Further studies by paying attention to above-mentioned bias sources are highly recommended to help making sure about the safety of this class of medications on bone.
  S. Hasani- Ranjbar , H. Vahidi , S. Taslimi , N. Karimi , B. Larijani and M. Abdollahi
  Several drugs may increase blood prolactin concentration. Dopamine receptor antagonists are one of the most common causes of hyperprolactinemia. To reduce happening of hyperprolactinemia, some medicinal plants have been traditionally used. This review focuses on the efficacy of effective herbal medicines in the management of human drug-induced hyperprolactinemia. PubMed, Scopus, Web of science, Cochrane library database were searched for any relevant studies that investigated the effect of herbal medicines on drug induced hyperprolactinemia up to May 2010. The inclusion criteria were clinical trials studied efficacy of herbal medicines in drug-induced hyperprolactinemia. Among different compounds, four herbal supplements including Shakuyaku-kanzo-to (TJ-68), Peony-Glycyrrhiza Decoction (PGD), Zhuangyang capsule, Tongdatang serial recipe (TDT) were found clinically effective and safe in management of drug-induced hyperprolactinemia. Although, the quality of included clinical trials was low not allowing us to conduct a meta-analysis but positive results on efficacy (TJ-68), (PGD), Zhuangyang capsule and (TDT) cannot be ignored. Interestingly compounds with prolactin-suppressive effects have a number of diterpenes mainly clerodadienols that seem almost identical for their efficacy. Further studies to isolate and characterize constituents of the effective herbs are needed to reach novel therapeutic and more effective agents.
  N. Amini-Shirazi , R. Ahmadkhaniha , S. Shadnia , M.H. Ghahremani , M. Abdollahi , A. Dadgar and A. Kebriaeezadeh
  In this study, we determined and evaluated the correlation between the dose of Valproate (VPA) and the concentrations of VPA and two important metabolites (2-ene-VPA and 4-ene-VPA) in serum of intoxicated patients referred to Loghman hospital. VPA poisoning is an increasing clinical problem. 2-ene-VPA is neurotoxic and the 4-ene-VPA has a key role in hepatotoxicity of VPA. Following clinical evaluations, two blood samples at referring time (time zero) and 12 h later were collected from 19 intoxicated patients. VPA and its metabolites were extracted from serum samples and measured using Gas chromatography-mass (GC-MS) spectrometry analysis. There was a correlation between VPA dose and concentration of VPA in serum of intoxicated cases at referring time (p<0.01). Significant reduction between mean serum concentration of VPA and metabolites was observed after 12 h (For VPA p<0.05, for 2-ene-VPA and 4-ene-VPA p<0.01). Evaluation of serum levels of VPA metabolites can provide information about potential risk of side effects and better management of patients.
  S. Nikfar , M. Darvish-Damavandi and M. Abdollahi
  Pouchitis is the most frequent long-term complication of Ileal Pouch-Anal Anastomosies (IPAA) surgery for Ulcerative Colitis (UC) which is a nonspecific inflammation of the ileal reservoir. Its clinical frequency varies depending on the definition and the follow up but is approximately 50% after a decade. Antibiotics and probiotics are currently the most widely accepted treatment in pouchitis patients. Objective of this study was to meta-analyze efficacy of probiotics and antibiotics in the management of pouchitis. All databases specially Pubmed, Web of Science, Scopus, Cochrane and Google Scholar were searched between 1965 and December 2009 and relevant controlled clinical trials were extracted, reviewed and validated according to the study protocol. The outcome of interest was defined by a Pouchitis Disease Activity Index (PDAI)<7. Thirteen clinical trials were included in the meta-analysis. Pooling of the results from eight trials yielded a Relative Risk (RR) of 5.33 with a 95% CI of 2.12-13.35 and a significant RR (p = 0.0004) in all kind of probiotics treatment group in comparison with the placebo group. Summary RR for clinical improvement in six trials was 14.17 with a 95% CI of 1.19-168.93 (p = 0.036) in efficacy of VSL#3 (all doses) comparing to placebo and slightly more effective for VSL#3 (6 g day-1) comparing to placebo with RR of 20.35 with a 95% CI of 6.16-67.22 (p<0.0001). Efficacy of antibiotics comparing to placebo showed a summary RR of 2.68 with a 95% CI of 0.4-17.99 and p = 0.3107 for clinical improvement in three trials. The summary RR for efficacy of ciprofloxacin comparing to metronidazole was 0.68 with a 95% CI of 0.44-1.06 (p = 0.8913). In conclusion, alongside the benefit of probiotics and antibiotics in the management of pouchitis, effects of probiotics and antibiotics on pouchitis vary according to different mixtures of microorganisms strains in probiotics and different spectrums of antibiotics.
  S. Shadnia , S. Ashrafivand , S. Mostafalou and M. Abdollahi
  Since oxidative stress markers are increased in Organophosphates (OPs) toxicity, the efficacy of the antioxidant N-acetyl-L-cysteine (NAC) as an adjunct therapy to atropine and pralidoxime for acute OPs toxicity was evaluated. Twenty-four adult subjects with acute OP toxicity were included in a randomized single blind controlled trial on the use of intravenous NAC. Among included subjects, twelve were randomized to receive NAC and the rest did not receive NAC. The results showed that the needing to atropine but not pralidoxime was reduced in NAC group. The duration of hospitalization was reduced in the NAC group. Addition of NAC to current treatment protocol of acute OPs poisoning is recommended.
  F. Soleymani , G. Shalviri and M. Abdollahi
  To compare the prescribing and usage pattern of all dosage forms of tramadol and to assess the type and frequency of tramadol-induced adverse drug reactions. All insured prescriptions which were collected in special software called Rx Analyst in the National Committee of Rational Drug Use were reviewed for prescriptions included at least one dosage form of tramadol. Data related to dispensing of tramadol were obtained from the official databank of national regulatory authority. All registered tramadol forms that induced adverse drug reactions in the database of Iranian Adverse Drug Reaction Monitoring Center were analyzed. The study period for all mentioned data was defined from 2006 to 2010. There were 291, 940 dosage forms of tramadol in 336, 610, 664 insured prescriptions in comparison to 1, 474, 680, 760 number of all dosage forms which dispensed from wholesaler to retail pharmacies during five years in the study. There were 461 different adverse reactions occurred in 249 patients. The most reported reactions included convulsion (73 items), nausea (56 items) and vomiting (47 items). We detected three death suspected to be induced by tramadol. Assessment of the trend of adverse reactions showed that the total number of reports was reduced from 89 cases in 2006 to 21 in 2010. There is a gap between number of tramadol prescribed and dispensed in the country that may be related to self-medication of this medicine. This has important value for priority setting in implementing interventions for promoting rational use of tramadol.
  M. Khanavi , H. Azimi , S. Ghiasi , S. Hassani , R. Rahimi , S. Nikfar , Y. Ajani , M.R. Shams-Ardekani and M. Abdollahi
  In the present study, cAMP and cGMP phosphodiesterase inhibitory (PDEI) activities of the ethanolic extracts of nineteen plants of Traditional Iranian Medicine (TIM) with aphrodisiac effects were investigated. The plants were extracted in a similar way and then three concentrations (0. 1, 1, 5 mg mL-1) from each were tested for PDEI activity against control and sildenafil. Among plants tested, 8 including Allium cepa, Trigonella foenum-graecum, Brassica rapa, Alpinia officinarum, Tribulus terrestris, Urtica pilulifera, Linum usitatissimum and Zingiber zerumbet exhibited a significant dose-dependent cAMP-PDEI activity and 6 including A. cepa, A. officinarum, T. terrestris, L. usitatissimum, Withania somnifera and Z. zerumbet gave a remarkable dose-dependent cGMP-PDEI effects in comparison to control. Among tested herbs, Zingiber officinalis and Peganum harmala at dose of 5 mg mL-1 demonstrated better cGMP-PDEI in comparison to sildenafil. The results of this study give idea for discovery of safe and better drugs in management of erectile dysfunction.
  S. Mostafalou and M. Abdollahi
  Not Available
  A.H. Abdolghaffari , S. Nikfar , H.R. Rahimi and M. Abdollahi
  Although, positive role of special bacteria in induction of Inflammatory Bowel Disease (IBD) including Ulcerative Colitis (UC) and Crohn’s Disease (CD) have been demonstrated in several studies but the consensus on etiology of IBD and beneficial effect of antibiotics has not been reached yet. And, also, no well-designed clinical trials in this regard have been done yet. This review focuses on various clinical trials which have been done in according to beneficial use of antibiotics in UC and CD from 1978 to date. For this purpose, all electronic databases such as PubMed, Scopus, Google Scholar and Cochrane library were searched. The results of clinical trials suggested that metronidazole, ciprofloxacin or the combinations of these antibiotics are effective in CD. However, ciprofloxacin is the first choice, because it has good coverage on gram negative and anaerobic bacterium which plays an important role in CD. However, there is a controversy on the use of antibiotics in UC and the efficacy of them in long-term treatment of UC is still in doubt. Various antibiotics such as anti-tuberculosis, macrolides (clarithromycin), fluoroquinolones, 5-nitroimidazoles, rifaximin, rifamycin derivatives (rifampin), aminoglycosides (tobramycin), rifabutin, clofazimine, tetracyclines (tetracycline and doxycycline) and vancomycin have been under attention of researchers in the recent years. Furthermore, other antibiotics with lower cost and adverse effects, effectiveness and availability are the third generation of cephalosporins and gentamicin and also penicillin or clindamycin that should be evaluated in future studies.
  H.A. Arab , S.H. Mardjanmehr , A. Shahbazfar , A. Rassouli , M. Abdollahi and O. Nekouie
  The present study aimed to find LD50 of artemisinin and to characterize the single dose toxicity of the drug following oral exposure. 49 day-old Ross broilers divided into 7 groups; one control, one drug vehicle and five treatment groups. The treatment groups received artemisinin alcoholic solution at doses of 10, 50, 250, 1250 and 2500 mg/kg on day 30 by a crop tube. The control and drug vehicle groups received normal saline and ethyl alcohol, respectively. In the period of study just in 1250 and 2500 mg/kg groups there were a few transient neurological signs like depression and unconsciousness. These signs were also observed in drug vehicle group. None of the birds died, so they were euthanised on day 40. In microscopic examination, only in treatment groups a slight degeneration in liver and kidney as intracytoplasmic eosinophilic inclusions, hepatocellular swelling and bile retention in liver were evident. In brain central chromatolysis, scattered neuronal necrosis, spongy change and focal axonal swelling were observed. It is concluded that artemisinin has a good margin of safety in poultry but in very high doses it may cause some adverse effects.
  D. Shahbazi , A. Gookizadeh and M. Abdollahi
  The aim of this study is to determine and compare the dosimetric consequences of prostate and normal structures (rectum, bladder and right femoral heads) in pelvis region using different conventional radiotherapy techniques 4-field (box), 3-field with one anterior and two oblique 115 and 245 ° fields and anterior-posterior technique) with two different energies of 9 and 18 MV. In this study two high-energy linear accelerators (Neptun 10 and Saturn 20) located in Seyed-Alshohada hospital in Isfahan were used. An anthropomorphic pelvic phantom was designed and fabricated for dosimetry applications based on the pelvic CT images of an adult patient with an average size of prostate cancer patients referring to the medical center. Measurements of the organ doses was performed in phantom using TLD (TLD-100) dosimeters, which was suited at different depth especially in prostate, rectum, bladder and femur head. After drawing the fields on the phantom, the photon beam at a dose of 200 cGy with various levels of photon energy (9 and 18 MV) were used. One way ANOVA test was used to data analysis. The measured percentage depth dose (DD%) in 4-field technique using photon 9 MV to the prostate, rectum, bladder and right femoral heads were 94.8, 85.71, 77.51 and 65.81%, respectively and using 18 MV photon beam they were 95.81, 86.73, 77.5 and 63.45%, respectively. The amount of DD%, in the 3-field technique with 9 MV photon, to the prostate, rectum, bladder and right femoral heads was found to be 91.7, 78.83, 93.4 and 63.25%, respectively and 92.38, 79.05, 93.31 and 62.05% when 18 MV photon beam were used. Using the 9 MV photon beam in AP-PA technique, prostate, rectum, bladder and right femoral heads received 96.23, 96.77, 96.3 and 28.77% of prescribed doses, while with 18 MV photon radiation they were 95.77, 96.91, 95.82 and 26.69%, respectively. Differences among the techniques have been found for all of four considered organs with total prescribed dose of 60 Gy and there was no significant difference among all considered techniques. Technique 3-filed give the best sparing of the rectum; the bladder is better spared with technique box and the best technique for sparing the femoral head is AP-PA. Differences between energies were low and using 18 MV photons give the more satisfied results.
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