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Articles by M. Helal U. Biswas
Total Records ( 2 ) for M. Helal U. Biswas
  M. Zakir Sultan , Zakia Sultana Sathi , M. Helal U. Biswas , M. Akteruzzaman Choudury , M. Aziz Abdur Rahman and M.A. Gafur
  The ethyl acetate extract of yeast extract-glucose broth medium of an Actinomycete strain, Streptomyces yielded three active metabolites C-1, C-2 and C-3, among which C-3 was identified as 2-N-butanamide-3-methyl-4-methoxy-5-β-L-arabinosyl-propanophenone on the basis of spectral data. The cytotoxic activity of the crude ethyl acetate extract and compound 1, 2 and 3 were determined by brine shrimp lethality bioassay. The compounds showed lower LC50 values indicating that these compounds were significantly cytotoxic. The LC50 of the crude ethyl acetate extract, C-1, C-2, C-3 and standard ampicillin trihydrate were 6.69, 12.30, 4.67, 6.62 and 10.28 μg ml-1 respectively.
  M. Shah Alam Bhuiyan , Yuji Ito , Naotaka Tanaka , Golam Sadik , Kiyotaka Fujita , Atsuko Nakamura , M. Helal U. Biswas , Hiroshi Fukui and Kaoru Takegawa
  In order to obtain more insights into the molecular mechanisms of action of polyene antibiotics in yeast cells, a number of nystatin sensitive mutants of Saccharomyces cerevisiae were isolated by ethylmethane sulfonate mutagenesis. The mutants were characterized in terms of their sensitivity test to stresses such as high temperature or high concentration of monovalent and divalent cations. The invertase overlay assay method suggests that some of these mutants are defective for vacuolar protein sorting. By tetrad analysis four of these mutants were found to possesses single gene mutation.
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