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Articles by L.O. Ehigie
Total Records ( 2 ) for L.O. Ehigie
  B.M. Olabinri , M.T. Olaleye , O.O. Bello , L.O. Ehigie and P.F. Olabinri
  The influence of concentration on hydroxyl radical scavenging and antioxidant activities of polyphenol extracts of Mango and Pawpaw leaves were assessed in vitro. The polyphenol extract from Mango leaves failed to scavenge hydroxyl radical at all the concentrations (50-250 μg mL-1) while Pawpaw leaves failed to scavenge hydroxyl radical at three different concentrations out of five concentrations investigated (50-250 μg mL-1). The polyphenol extract from Pawpaw leaves was a poor scavenger of hydroxyl radical in vitro (4.2% maximum scavenging activity). The polyphenol extracts of Mango and Pawpaw leaves exhibited weak antioxidant activities in vitro at all the concentrations investigated. Mango leaves had the highest total phenolic concentration (128 mg mL-1) at the maximum extraction time (50 min). At 50 min extraction time both the aqueous extracts of the two plants demonstrated maximum antioxidants activity (86.95% for aqueous extract of Mangifera indica and 89.70% for Pawpaw aqueous extract). A non-significant moderate positive correlation was observed between total phenolic concentration and antioxidant activity of aqueous extract of Mangifera indica and that of Pawpaw leaves (r = 0.592; p = 0.05 for Mangifera indica; r = 0.469; p = 0.05 at 20 min extraction time).
  P.B. Fakunle , A.J. Ajibade , L.O. Ehigie , O.A. Alamu and E.A. Ashamu
  Alcohol abuse and misuse has been widely reported to impair vision with majority of information available implicating the retina but with very scanty literature laying emphasis on the visual relay centers. Hence, some effects of chronic administration of ethanol was studied on the neuronal cells population in the visual relay centers Lateral Geniculate Body (LGB) and Superior Colliculus (SC) of 40 adult Wistar rats of both sexes grouped into treatments T1 and T2 and controls C1 and C2. The treatment groups received 25% ethanol in 2% sucrose (ad libitum) for 6 weeks except T2 animals that were made to undergo an additional 2 weeks of ethanol withdrawal period while the control groups C1 and C2 received tap water and 2% sucrose solution, respectively for 6 weeks. At the end of administration, the animals were sacrificed and process for routine histological techniques and stained for nissl substances. Body weight loss was significantly (p<0.05) observed as well as significantly (p<0.05) reduced neuronal cells population of 47 and 40% for LGB and 42 and 38% for SC neuronal loss, respectively in treatment groups T1 and T2 compared to control group. Hence, these alterations may again underline visual imbalance associated with the malfunctioning of the visual relay center most especially in the maintenance of saccade and recoding of visual signals which are postretinal related functions.
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