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Articles by L. O. Ehigie
Total Records ( 1 ) for L. O. Ehigie
  B. M. Olabinri , O. O. Odedire , M. T Olaleye , A. S. Adekunle , L. O. Ehigie and P. F. Olabinri
  The hydroxyl and nitric oxide radical scavenging activities and total phenolic content of artemether were investigated in vitro. The concentrations of artemether (200-1000 μg mL-1) did not exhibit hydroxyl radical scavenging activity except at 200 μg mL-1 concentration. The mean values for the hydroxyl radical scavenging for the different concentration (200, 400, 600, 800 and 1000 μg mL-1) of artemether were 47.55±11.28, -3.49±13.16, -30.09±6.09, -34.74±4.29 and -49.00±7.75%, respectively. The total phenolic content of artemether in ethylacetate ranged from 208.00±48.33 (SD) to 340.00±14.14 μg mL-1, while the total phenolic content of artemether in methanol ranged from 90.00±6.3 (SD) to 122.00±35.44 μg mL-1. Total phenolic content of artemether was significantly higher in ethyl acetate than in methanol at all concentration investigated (p<0.05). The total phenolic content arthemeter was influenced by the organic solvent used as a medium for preparing artemether.
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