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Articles by Kurdistan Sharifzadeh
Total Records ( 2 ) for Kurdistan Sharifzadeh
  Mohammad Sharifzadeh , Mahsa Raoufi , Amir Abbas Zahedinejad , Nourollah Aghaebrahimi , Kurdistan Sharifzadeh and Mohammad Abdollahi
  The effects of chronic lead acetate treatment on alterations of Auditory Brainstem Response (ABR) induced by gentamicin and amikacin were tested in guinea pigs. This study was designed to investigate the hypothesis that aminoglycoside antibiotics and lead via their effects on phosphoinositide pathway and calcium channels may influence ototoxicity mechanisms as tested on the auditory brainstem response. Intramuscular injection of different doses of gentamicin (5, 10 mg/kg/day) and amikacin (150, 300 mg/kg/day) for three weeks induced hearing loss. Administration of lead acetate (0.05%, 35 days) in drinking water changed ABR (absolute wave latency). The gentamicin-induced alteration of ABR were attenuated by chronic lead acetate pretreatment in guinea pig. Obtained data suggest the interactions between chronic lead acetate and aminoglycoside antibiotics in alterations of auditory functions which could be accounted for, at least partially, by perturbations of the phosphoinositide and calcium cascades within the inner ear.
  Mohammad Sharifzadeh , Kurdistan Sharifzadeh , Mahnaz Khanavi , Abbas Hadjiakhoondi and Abbas Shafiee
  The aim of this study was to evaluate the anti-inflammatory activities of total methanolic extracts isolated from aerial parts of Stachys persica and Stachys setifera. The anti-inflammatory properties of the extracts were assessed by using two well-characterized inflammatory models, carrageenan-induced paw edema and formalin test in rats and mice. Intraperitoneal injections of the extracts 60 min before carrageenan injection caused significant inhibition on carrageenan-induced paw edema over the dose range 50-200 mg kg-1. The extract of Stachys persica showed more inhibitory effect especially with higher doses (100 and 200 mg kg-1). In the formalin test, intraperitoneal injections of different doses (50, 100 and 200 mg kg-1) of either Stachys persica or Stachys setifera 30 min before formalin injection did not show any inhibitory effects in the first phase (0-10 min) of the formalin-induced pain, but all three doses of the extracts revealed a significant (p<0.01) blockade of the second phase (20-30 min) nociception. The anti-inflammatory properties of both extracts were comparable with indomethacin as a potent non-steroidal anti-inflammatory drug. In conclusion, the present findings provide further evidences for inhibitory effects of Stachys persica and Stachys setifera in inflammatory processes via possible interactions with cyclooxygenase products.
 
 
 
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