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Articles by K.O. Ajeigbe
Total Records ( 3 ) for K.O. Ajeigbe
  K.O. Ajeigbe , E.O. Nwobodo , T.O. Oyesola , D.A. Ofusori and S.B. Olaleye
  The aim of this study was to investigate the effect of Chloroquine phosphate (at therapeutic dose) on existing gastric ulceration in albino rats. Rats were treated with Chloroquine phosphate (8.5 mg kg-1) intramuscularly for 24 h after formation of ulcers induced by acidified ethanol and indomethacin. Following sacrifice, colorimetric assays were applied to determine the concentration of protein and mucus, activities of catalase and lipid peroxidation in homogenized gastric mucosal samples. Chloroquine phosphate worsens gastric lesions produced by both indomethacin and acidified ethanol. Also, it seemed to elaborate the indomethacin and acidified ethanol induced effects on gastric juice volume, pH and acid output. On the other hand, thiobarbituric acid reactants (TBAR) was further increased and protein, catalase and mucus were decreased in the gastric mucosal samples. The data indicates that the use of Chloroquine may be dangerous to the integrity of the stomach, especially in existing gastric ulcers. It increases oxidative stress in the gastric mucosa caused by indomethacin and acidified ethanol.
  S.B. Olaleye and K.O. Ajeigbe
  The aim of the present study was to investigate the effect of the therapeutic dose of sulfadoxine-pyrimethamine on experimentally induced gastric ulceration in albino rats. Rats were given sulfadoxine-pyrimethamine (22.5 mg kg-1) intramuscularly for 24 h after formation of ulcers induced by indomethacin or by acidified ethanol. Upon sacrifice, colorimetric assays were applied to determine the concentration of protein and mucus, activities of catalase and superoxide dismutase and lipid peroxidation in homogenized gastric mucosal samples. Sulfadoxine-pyrimethamine was observed to alleviate gastric lesions produced either by indomethacin or acidified ethanol. Also, the drug seemed to attenuate the indomethacin or acidified ethanol induced effects on gastric juice volume, pH and acid output. On the other hand, thiobarbituric acid reactants (TBAR) was decreased and superoxide dismutase (SOD) and catalase (CAT) activities increased in the gastric mucosal samples, though, however, protein and mucus concentrations remained statistically unchanged. The use of sulfadoxine-pyrimethamine may be safe on the integrity of the stomach, especially in existing gastric ulcers. It ameliorates oxidative stress in the gastric mucosa caused by indomethacin and acidified ethanol.
  K.O. Ajeigbe , S.B. Olaleye and E.O. Nwobodo
  In this study, the effects of two antimalarials-amodiaquine hydrochloride and artemisinin were investigated in ulcerated albino rats of Wistar strain. Rats were treated with amodiaquine (30 mg kg-1) and Artemisinin (2.86 mg kg-1) for 24 h after formation of ulcers induced by indomethacin. Treatments with Amodiaquine Hydrochloride led to significantly increased gastric lesions while artemisinin led to significantly decreased gastric lesions. Also, amodiaquine hydrochloride seemed to elaborate the indomethacin induced effects on gastric juice volume, pH and acid output, while artemisinin attenuated these changes. The data indicates that the use of amodiaquine hydrochloride may be dangerous to the integrity of the stomach, especially in existing gastric ulcers, while artemisinin is mild and ameliorating, may result from their lipid peroxidation/apoptosis activity interference.
 
 
 
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