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Articles by K.A. Sanda
Total Records ( 6 ) for K.A. Sanda
  M.S. Auwal , K.A. Sanda , I.A. Mairiga , F.A. Lawan , A.A. Mutah , A.N. Tijjani , A. Shuaibu , A. Ibrahim , A.B. Njobdi and A.B. Thaluvwa
  The phytochemical, elemental and hematologic effect of the crude mesocarp extract of Hyphaene thebaica (doumpalm) in wistar albino rats to ascertain the claims by herbalists and traditionalists in the management of anemia was evaluated. The Phytochemistry revealed the presence of tannins, saponins, steroids, carbohydrates, cardiac glycosides, flavonoids, terpenes and terpinoids in low and moderate concentrations. Alkaloids, phlobatannins and anthraquinones were absent. The elemental analysis of the extract revealed the presence of calcium, magnesium, potassium, iron and sodium in moderate concentration when compared to WHO concentration in ppm. The amount of manganese, zinc and silicon is low, whereas the amount of nickel, cobalt, molybdenum, arsenic and lead is negligible. There is significant (p<0.05) increase in red blood and white blood cells production at 1-4 weeks of extract administration, while parked cell volume and hemoglobin concentration increased at the second and third week of oral administration of 400, 600 and 800 mg kg-1 for four weeks of the extract respectively. This research have therefore supported the folkloric claims by traditionalists and herbalists in application of the crude mesocarp extract of Hyphaene thebaica (doumpalm) in the management of anemia in Askira/Uba, Maiduguri and other Local Government areas in Borno State, Nigeria.
  K.A. Sanda , U.K. Sandabe , F.A. Sanda , M.B. Tijjani , Y.B. Majama and B.G. Gambo
  Phytochemical screening of aqueous root extract of Leptadenia hastata was investigated in Maiduguri northern Nigeria, to evaluate the active component of the plant. Soxhlet extraction method was used to determine the phytochemical component of the extract. Saponins and flavonoids had high scores in the extract, alkaloids and pentoses had moderate scores, while tannins and ketones had low scores. Combined anthraquinones, free anthraquinones, reducing sugar, carbohydrates, glycosides and monosaccharides were not detected in the extract. In conclusion, Leptadenia hastata aqueous root extract contains pharmacologically active components which support its Ethno-botanical claims of traditional herbalist in Northern Nigeria in the treatment of various ailments.
  K.A. Sanda , H.A. Grema , Y.A. Geidam and Y.M. Bukar-Kolo
  In recent years, the use of herbal products has been increasing in developing countries such as Nigeria. The common guava tree (Psidium guajava) is a medium sized tree belonging to the family Myrtaceae which is native to tropical and subtropical countries. It is popular in an indigenous system of folk medicine. Traditionally guava is used for the treatment of various ailments like diarrhoea wounds, rheumatism, lung problems, ulcers etc. Psidium guajava L. contains a number of major pharmacologically active ingredients such as flavonoids, guayavolic acid, guavanoic acid, guajadial, guajaverin and so many other active principles. This review summarizes the current knowledge of major pharmacological constituents with major emphasis on traditional and pharmacological activities. This plant reported to display various biological activities like antidiarrhoeal, antimicrobial, antioxidant, hepatoprotective, anti-allergy, anti-plasmodial, anti-spasmodic, cardioactive, anti-diabetic, anti-inflammatory anti-nociceptive and antitussive activity. In view of its wide pharmacological and biological activities, it seems to be having a great therapeutic potential.
  Y.A. Geidam , U.I. Ibrahim , H.A. Grema , K.A. Sanda , A. Suleiman and D.L. Mohzo
  Antibiotics are still deemed necessary for the treatment and prevention of infectious diseases in farm animals intended for food production and to protect public health from food-borne diseases. One possible approach to the resistance problem is the appropriate use of antibiotics for prevention and treatment of infections. A survey was conducted to determine the antibiotic usage in poultry farms and the brand of antibiotics sold over the counter in drug outlets. Reputable poultry farms and drug outlets were identified and questionnaires were administered to 20 poultry farmers. A yes or no type of response was developed to assess level of reported purchase and use of antibiotics without prescriptions. Majority of the respondents (80%) agreed to have purchased an antibiotic without a prescription and the most commonly named antibiotics used by poultry farmers was Tetracycline (Oxytetracycline) 36.5%. It was available in all the drug stores (100%) visited. This was followed by amino glycosides (Neomycin) with 15.2% in poultry farms and 27.2% in drug stores. The widespread access to antibiotics without prescription with resultant inappropriate use, may lead to increased development of resistant strains.
  M.B. Tijjani , A.A. Barkindo , S. I. Ngulde , B. Wampana and K.A. Sanda
  Decoction of Detarium microcarpum, used by traditional herbalist as antidiarrheal agents, was investigated for its efficacy. Determination of phytochemical constituents of the aqueous extract was carried qualitatively using standard laboratory procedures. Experimentally-induced diarrhoea and intraluminal pooling and charcoal transit time using castor oil was used as a model for assessing antidiarrheal efficacy of the plant. The result showed that the plant contain alkaloid, tannins, flavonoids and carbohydrates. The extract gave a protection against castor oil induced diarrhoea of 53% compared with standard drug loperamide that gave 91% protection. Intraluminal fluid volume was significantly (p≤0.05) decreased compared negative control. Distance travelled by charcoal meal was found to be significantly (p≤0.05) lower than the negative control and is comparable to with the positive control group that received atropine. The results of this study suggest that the plant was found to possess antidiarrheal effect as claimed by herbalist.
  K.A. Sanda , U.K. Sandabe , M.S. Auwal , I. Bulama , T.M. Bashir , F.A. Sanda and I.A. Mairiga
  This study was designed to evaluate the antidiabetic profile and the hypoglycaemic activity of aqueous root extracts of L. hastata in normal and alloxan-induced diabetic rats model. Eighty five albino rats were used for this study out of this thirty five were used subjected to experimental diabetes by the use of alloxan at a dose of 160 mg kg-1 body weight. Seven experimental groups of five rats per group (A-G) were used for this study. A standard antidiabetic drug (insulin) group (B) and normal saline group (G) serves as positive control. The blood glucose lowering activity of the extract, insulin and normal saline groups were monitored at 0, 1, 3, 6, 12 and 18 h post extract administration. On the other hand the remaining fifty albino rats were used to determine the acute toxicity and the hypoglycemic activity of the extract. The blood glucose levels of the rats were monitored at 0, 7, 14, 21 and 28 days post extract administration. Oral administration of aqueous root extract at 600 and 800 mg kg-1 b.wt have significantly (p<0.05) decreased the blood glucose in diabetic albino rats. On the other hand the hypoglycemic activity of the aqueous root extract on normal rats at dose of 1000 mg kg-1 b.wt have significantly (p<0.05) decreases blood glucose level in normal albino rats. The results of the current study have demonstrated the antidiabetic and hypoglycaemic effects of L. hastata aqueous root extracts and underscore its potentials in the management of diabetes mellitus especially following prolonged use in days.
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