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Articles by K. Anam
Total Records ( 3 ) for K. Anam
  K. Anam , R.M. Widharna and D. Kusrini
  Terminalia arjuna, Terminalia ballerica, Terminalia chebula, Terminalia catappa, Terminalia kaerbachii and Terminalia microcarpa leaves were tested for their α-glucosidase inhibitory activity in vitro. The α-glucosidase activity was determined by measuring the p-nitrophenol release from pNPG at 400 nm. Terminalia kaerbachii has the highest α-glucosidase inhibitor activity with IC50 value of 0.27±0.17 μg mL¯1 and is a promising antidiabetic herbal medicine candidate. However, most of the Terminalia species are also potential as antidiabetic medicine candidates as the IC50 values are approximately 5 μg mL-1, which is near the IC50 value of 1-deoxynojirimycin, the reference compound, except for Terminalia microcarpa, which has IC50 value of 25.15±0.04 μg mL-1 (above 21 μg mL-1). From the phytochemical screening, Terminalia kaerbacchi contains alkaloids, flavonoids and cathechic tannins, but does not contain saponin, quinon, steroid/terpenoids and gallic tannins. It is estimated that there is a correlation between α-glucosidase inhibitory activity and its phytochemical content.
  K. Anam , A.G. Suganda , E.Y. Sukandar and L. Broto S. Kardono
  A component of ethylacetate extract of Terminalia muelleri Benth. leaves, was found to inhibit Staphyloccoccus aureus and Methicillin-resistant Staphylococcus aureus growth therefore, the aims of this study were to investigate the effect of the active components on morphology of bacteria cell which was observed by Scanning Electron Microscope (SEM) and Transmission Electron Microscope (TEM). Tetracycline HCl, penicillin G and vancomycin HCl were used as reference antibiotic. The active component at twice of the MIC caused shrinkage and thinning of the cell wall. The cell damage pattern which is caused by the active compound was similar to the damage caused by vancomycin HCl. It was explained that the antibacterial target of action of the active compound was inhibit the synthesis of the cell wall.
  K. Anam , A.G. Suganda , E.Y. Sukandar and L.B.S. Kardono
  The objective of this study was to know the antibacterial compound from T.muelleri. Extraction of leaf of T. muelleri using solvents of increasing polarity, namely, n-hexane, ethyl acetate and methanol, respectively, yielded dry extracts. The extracts were tested for antibacterial activity. Ethyl acetate extract exhibited the strongest activity against standard strains of Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922. The ethyl acetate extracts had been fractionated, yielded 9 fractions.The fraction EH exhibited the strongest activity against S. aureus. The separation of chemical contents of fraction EH was carried out by Sephadex LH-20 column chromatography, yielded a pure substance. The substances was identified as 3,4,5-trihidroxybenzoic acid by chromatographic and spectroscopic analysis. This substance is a well-known antibacterial activities. The activity of 1 mg 3,4,5-trihydroxybenzoic acid was equal to 0.1396 μg tetracycline HCl against S. aureus and 0.6455 μg against Methicilin-Resistant Staphylococcus aureus, also equals to 40.6035 μg penicillin G against S. aureus and equals to 2.9823 and 2.1213 μg vancomycin HCl against S. aureus and Methicilin-Resistant Staphylococcus aureus, respectively.
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