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Articles by Jasem Estakhr
Total Records ( 2 ) for Jasem Estakhr
  Vahid Rostamian , Farzaneh Shakeri and Jasem Estakhr
  Now-a-days, no-drug treatments (medicinal plants) are novel therapeutic approaches in the treatment of diabetes. This study aimed at assessing the effect of grape seed extract on the blood glucose and lipid profile in diabetic rats. A total of 30 male adult rats were randomly selected and divided into 3 groups as; non-diabetic control, diabetic control and diabetic rats treated with hydroalcoholic extract of grape seed. In diabetic groups, alloxan monohydrate (120 mg kg-1) was injected intraperitoneally to develop diabetes. Then the test group received intraperitoneal injection of hydro-alcoholic extract of grape seed (100 mg kg-1). At last, glucose, cholesterol, triglyceride, HDL, VLDL, LDL and insulin contents of the rats' serum sample were determined. Diabetic rats treated with extract showed a significant decrease in blood glucose level (p<0.05). Furthermore, compared diabetic group, in the extract-treated rats, there was a significant decrease in serum contents of Total Cholesterol (TC), LDL, VLDL and TG but a significant increase in insulin level and HDL (p<0.05). These results show that the hydroalcoholic extract of grape seed may be effective in the treatment of diabetes. This effect can be due to the presence of flavonoides and their antioxidant features.
  Nasim Javdan and Jasem Estakhr
  The present study was undertaken to determine the antioxidant activities of various extracts of whole plant of salvia hypoleuca in different in vitro methods. The antioxidant activity was evaluated by total antioxidant activity (Phosphomolybdic Acid Method), FRAP assay with reference standard ascorbate and total phenol content, respectively. The methanolic extract of salvia hypoleuca was the most effective total antioxidant activity among the three extracts. The IC50 values of the methanolic extract of salvia hypoleuca and ascorbate were found to be 160 and 410 μg mL–1, respectively. The methanolic extract of salvia hypoleuca was found more effective in FRAP assay than that of petroleum ether and ethyl acetate extracts. But when compare to the all the three extracts with ascorbate (standard), the methanolic extract of the salvia hypoleuca showed the significant result. The methanolic extract of Salvia hypoleuca contains high amount of phenolic compounds than that of other two extracts. So, the in vitro study clearly shows that the methanolic extract of salvia hypoleuca has a strong antioxidant activity. This study indicated that methanolic extract of salvia hypoleuca comprise effective potential source of natural antioxidant which might be helpful in preventing the progress of various oxidative stresses.
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