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Articles by Jacques Simpore
Total Records ( 4 ) for Jacques Simpore
  Jacques Simpore , Denise Ilboudo , Damintoti Karou , Virginio Pietra , Marisa Granato , Maria Esposito , Roberta Santarelli , Salvatore Pignatelli , Augustin Bere and Antonio Angeloni
  We analyzed the prevalence of Human Herpes Virus-8 (HHV-8), Human Immunodeficiency Virus (HIV), Hepatitis C Virus (HCV), Hepatitis B Virus (HBV) infections among pregnant women in Burkina Faso, to estimate the seroprevalence of HHV-8 infection in this sub-Saharan country and to evaluate the co-infection rates for these viruses. Sera collected from pregnant women (n = 1420) were assayed to determine HIV prevalence. Subsequently, (n = 429) were tested to detect HHV-8, HCV and HBV infections. 108/1420 (7.61%) subjects were found HIV seropositive and the risk of being infected increases with age. Among the 429 women screened, 49 were HHV-8 infected (11.4%), 26 were seropositive for HCV (6.1%) and 40 were HBsAg positive (9.3%). Co-infection rates among HIV infected individuals were: 16/108 HHV-8 positive (14.8%), 14/108 HBV (12.9%) HBsAg positive, 8/108 (7.4%) HCV positive. Prevalence of HHV-8 infection in the analyzed population of Burkina Faso is lower than that found in other regions of Central Africa and this is in keeping with the low incidence of Kaposi`s sarcoma observed in this country. Moreover, this research enabled us to estimate the prevalence of the co-infections of the HIV, hepatitis B and hepatitis C within our group of study. Considering only the three types of infections: HHV-8, HCV and HBV without taking into account the HIV, only 75.06% (322/429) of these women do not have any viral infection. This remark is very significant and it must be taken in consideration in the hospitals, at the time of the blood transfusions in emergency.
  Cecilia Zuppi , Jacques Simpore , Bruno Zappacosta , Cinzia Carrozza , Mariano Malaguarnera and Salvatore Musumeci
  Biological aging implies a progressive decrease of endocrine and metabolic resources, which correspond to a reduction of working activity and caloric intake. The aim of this study was to measure DHEA-S and IGF-1 and products of methionine metabolism in 76 postmenopausal African women (50 to 100 years of age) compared to 22 adult African fertile women (30 to 45 years of age). Determination of plasma DHEA-S in elderly women gave a markedly low mean concentration and the same was observed for plasma IGF-1 (450.1±263.2 and 64.2±38.1 ng mL-1, respectively). The correlation between DHEA-S and IGF-1 was significantly positive only in 71-100 years women (r = 0.44, p<0.05). There was a significant decrease of plasma glutathione in all elderly women (3.5±0.4 μMol L-1), while the plasma homocysteine (Hcy) was markedly elevated (18.7±0.5 μMol L-1), whilst that of folic acid, Vit B12 and Vit B 6 levels were found in the normal range. A significant positive correlation between DHEA-S and plasma glutathione levels (r = 0.56, p<0.025) was found only in the 50-60 old years women group, while the correlation between IGF-1 and plasma glutathione was negative but not significant (r = -0.36, p = NS) in the same age group. In this study a low level of IGF-1 and DHEA-S in old humans is firstly considered as consequence of hypo-caloric alimentation, moderate physical activity and absence of psychophysics stress. Moreover a positive correlation between IGF-1 and DHEA-S in oldest age populations, ranging from 71 to 100 years, suggests that endocrine and metabolic systems must be maintained in a lower equilibrium to compensate the physiological reduction of the oxidant/antioxidant balance (low level of plasma glutathione).
  Jacques Simpore , Frederic Zongo , Youssouf Ouattara , Fatoumata Kabore , Deleli Dansou , Augustin Bere , Jean-Baptiste Nikiema and Salvatore Musumeci
  The objective of the study was to assess the impact of an alimentary integrator composed by Spiruline (Spirulina platensis), produced at the Centre Medical St Camille (CMSC) of Ouagadougou, Burkina Faso, on the nutritional status of undernourished HIV-infected and HIV negative children. We compared two groups of children: 84 children HIV-infected and 86 HIV-negative. The duration of this study was eight weeks. Anthropometrics and haematological parameters allowed us to appreciate both the nutritional and biological effects of Spiruline supplement to traditional meals. The rehabilitation with Spiruline shows on average a weight gain of 15 and 25 g/day in HIV-infected and in HIV negative children, respectively. The level of anaemia decreased during the study in all the children, but the recuperation was less efficient among the HIV-infected children, in fact, 81.8% of HIV negative undernourished children recuperated against 63.6% of HIV-infected children [Z: 1.70 (95% CI: -0.366, -0.002, p=0.088)]. Present results allow to confirm that Spiruline is a good food supplement for undernourished children. In particular the rehabilitation by Spiruline seems to correct the anaemia and the weight loss also in HIV-infected, but more quickly in HIV negative undernourished children.
  Simplice Damintoti Karou , Tchadjobo Tchacondo , Micheline Agassounon Djikpo Tchibozo , Saliou Abdoul-Rahaman , Kokou Anani , Koffi Koudouvo , Komlan Batawila , Amegnona Agbonon , Jacques Simpore and Comlan de Souza
  Context: The Tem tribe in the Central Region of Togo is a population with an extensive knowledge of medicinal plants. However, little is known about their medical practices, principally the use of plants in the management of diabetes mellitus (DM) and hypertension (HTN). Objective: The present study documented the indigenous medicinal plant utilization for the management of DM and HTN in the Togo Central Region. Methodology: From March to October 2010, 55 traditional healers were interviewed about their knowledge on the use of plants for DM and HTN treatment. Results: The results revealed that 35/55 (63.64%) healers had treated at least one case of DM and/or HTN. They highlighted the use of 64 species belonging to 31 families in the treatment of DM and/or HTN. The most used plants against diabetes were Psidium guajava L. (Myrtaceae), Khaya senegalensis A. Juss. (Meliaceae), Sarcocephalus latifolius (Sm.) E.A. Bruce (Rubiaceae), Annona muricata L. (Annonaceae), Bridelia ferruginea Benth. (Phyllanthaceae), and Securidaca longepedunculata Fresen. (Polygalacae), while Allium sativum L. (Liliaceae) and Parkia biglobosa Benth. (Fabaceae), followed by Khaya senegalensis A. Juss. (Meliaceae), Gardenia ternifolia Schumach. (Rubiaceae), and Persea americana Mill. (Lauraceae) were the most commonly cited as antihypertensive. Conclusion: The issue revealed that traditional healers of the above mentioned region have basic knowledge regarding herbal medicine for DM and HTN in comparison with previous published reports. Further pharmacological screening of the identified plants should be conducted to ascertain the effectiveness of these plants.
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