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Articles by J.O. Ayo
Total Records ( 5 ) for J.O. Ayo
  B.I. Onyeanusi , A.A. Adeniyi , J.O. Ayo and J.O. Nzalak
  Morphometric studies were carried out using standard procedures on the kidney of the African Giant Rat (AGR). The average kidney weight was 2.085±0.044 g. The right kidney was significantly (p< 0.05) heavier than the left. The male kidneys were larger than those of the female and the values obtained were 2.119±0.062 g and 2.053±0.009 g, respectively. The average liveweight of the AGR was 8.63.520±3.74 g. The relative thickness of the medulla was 4.30. The results of the present study provide baseline morphometric data on the kidney of the AGR which had been lacking. The value of the relative thickness of the medulla (4.3), similar to those of the dog (4.2) and the cat (4.8), suggests that the AGR does not have special anatomical adaptation in the urinary system for water economy. The capability to thrive well in arid environment probably lies somewhere else.
  L.J. Hamidu , J.O. Ayo , A.B. Adelaiye and M.S. Abubakar
  This study evaluated the central action of Waltheria indica extract. Aqueous ethanolic extract of the plant showed bioactivity in acetic-acid induced stretches in animal model. The central effects of the most biologically active fraction (ethyl acetate) of extract of Waltheria indica was evaluated in mice using the elevated plus maze paradigm and the strychnine and leptazol-induced convulsions. Sedative effect was studied using the amylobarbitone-induced sleeping time. The extract fraction significantly (p< 0.05) increased the amylobarbitone sleeping time and protected (100%) mice from death due to pentylenetetrazole convulsion. The extract failed to protect mice against strychnine convulsion, even though it delayed the time of onset of death. The exploratory activity was also significantly (p< 0.05) decreased in the extract treated mice. The extract blocked leptazole-induced convulsion, potentiated amylobarbitone sleeping time and decreased exploratory activity, indicating anticonvulsant and sedative actions.
  S.F. Ambali , M. Mamman , A.O. Adaudi , K.A.N. Esievo , J.O. Ayo and M.S. Abubakar
  The aim of this study is evaluate the curative and protective effects of penicillin G in mice poisoned with the lyophilized extract of Chlorophyllum molybdites. Fifty Swiss albino mice were divided into 5 groups of 10 mice each. Mice in group 1 were pretreated with penicillin G at 38, 280 IU kg-1, i.p. and then dosed with LD99 of C. molybdites (741 mg kg-1) i.p., mice in group 2 were dosed with the extract and then treated with penicillin G, while mice in group 3 were dosed with the extract only. Mice in groups 4 and 5 were dosed with penicillin G and physiological saline solution, respectively. The mice were monitored for clinical signs of toxicity, pathological lesions and death over a period of 72 h. The mean time of death in mice from penicillin-treated groups 1 and 2 were compared with those in the extract-treated group using one-way analysis of variance (ANOVA) and values of p<0.05 were considered significant. The result showed a significant reduction in the severity of clinical signs and mortality in penicillin-treated groups 1 and 2 compared to the group dosed with only the extract. There was a significant difference in the mean time of death in mice from groups 1, 2 and 3. However, there was no reduction in the severity of lesions in mice from groups 1 and 2 treated with penicillin G compared with extract-treated group. Therefore, this study has shown that penicillin G has significant curative and protective effects in mice poisoned with the lyophilized extract of C. molybdites. This result may prove useful in the treatment of humans and animals suffering from C. molybdites poisoning.
  N.S. Minka , A. Fayomi and J.O. Ayo
  The study investigated the effect of ethanol extract and ethyl acetate soluble fraction of Calyces of Hibiscus sabdariffa (C.H.S) on hyperthermia, hematology and behaviour of laying hens during the hot-dry season. Experimental layers administered orally ethanol extract or ethyl soluble fraction of C.H.S at doses of 200 mg kg 1, respectively, maintained a normal rectal temperature value and lower Heterophil Lymphocyte (H L 1) ratio. They did not exhibit any stressful behaviours of excess water intake, wing fluffing or panting. The control layers not administered with any extract had higher (p< 0.01) rectal temperature values, H L 1 ratio and exhibited stressful behaviours, including 10% mortality rate. The correlated results between the atmospheric temperature and rectal temperature and behaviour of panting were significant and negative (p< 0.05) in experimental layers. In control layers the correlation was significant and positive (p< 0.05). The results showed that C.H.S reduced or eliminated the effect of heat stress in the layers. The calyces might have direct or indirect inhibitory and immuno-modulating effects on the nervous system, apart from its antioxidant and antibacterial property. Hence, could be used in ameliorating the negative effect of heat stress on laying hens predominantly reared under hot climatic conditions.
  A.Y. Adenkola and J.O. Ayo
  Experiments were performed on 40 indigenous turkeys with the aim of investigating, fluctuations in their Rectal Temperature (RT) and the effect of Ascorbic Acid (AA) on during the hot-dry season. Twenty turkeys which served as experimental birds were administered AA orally at the dose of 52 mg g 1, while the remaining 20 turkeys which served as control were given ordinary water. Measurements of RT were taken for 3 days, one week apart, every hour from 06:00-19:00 h. The results showed that RT values in both experimental and control turkeys significantly (p<0.01) fluctuated with the h of the day (r = 0.614, 0.612, respectively) and the dry-bulb temperature (r = 0.794, 0.928, respectively). The RT value of 41.20.03C recorded in experimental turkeys was significantly lower (p<0.05) than the corresponding value of 41.50.03C obtained in control turkeys. The results demonstrated that AA significantly reduced RT values in experimental turkeys. In conclusion, AA administration may be of value in turkeys subjected to unavoidable stressful conditions during the hot-hours of the day.
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