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Articles by J.N. Efienokwu
Total Records ( 1 ) for J.N. Efienokwu
  L.E. Okonko , N.O. Sam-Uket and J.N. Efienokwu
  Background and Objective: Globally, there is growing interest in plant based antioxidants since some synthetic products are reported as carcinogenic. This research was, therefore, designed to investigate in vivo antioxidant activities of African basil and African nutmeg aqueous extracts in Wistar rat. Materials and Methods: Fifty female Wistar rats were divided randomly into 10 groups (I-X) of five each. Rats in group I received only water, group II received 10 mg kg1 b.wt., of carbon tetrachloride (CCl4) and groups III and IV received 200 and 300 mg kg1 b.wt., of O. gratissimum, respectively. Groups V and VI received CCl4 plus 200 mg kg1 b.wt., and CCl4 plus 300 mg kg1 b.wt., of O. gratissimum, respectively. Groups VII and VIII received 200 and 300 mg kg1 b.wt., of M. myristica, respectively whereas, groups IX and X received CCl4 plus 200 and CCl4 plus 300 mg kg1 b.wt., of M. myristica, respectively. Treatments were administered via oral gavage for 60 days. Animals were sacrificed and blood samples were collected for biochemical analysis (alanine transaminase, aspartate transaminase, alkaline phosphatase, albumin, total bilirubin and total protein). Results: Rats administered CCl4 exhibited significant (p<0.05) elevation in all the analyzed parameters (except total protein and albumin) compared to the control. Aqueous extracts of O. gratissimum and M. myristica maintained liver enzymes within the control values, whereas each extract plus CCl4 reduced liver enzymes compared to CCl4 treated group. Conclusion: The findings of this study suggest that both extracts could offer protection against CCl4-induced liver damage (oxidative stress) due to their antioxidant activities.
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