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Articles by J. Zhou
Total Records ( 5 ) for J. Zhou
  A Takakura , L Contrino , X Zhou , J. V Bonventre , Y Sun , B. D Humphreys and J. Zhou

The ‘two-hit’ model is a widely accepted genetic mechanism for progressive cyst formation in autosomal dominant polycystic kidney disease. We have previously shown that adult inactivation of Pkd1 using the Mx1Cre+ allele causes a late onset of focal cystic disease. An explanation for the delayed appearance of cysts is the requirement for an additional independent factor, or ‘third hit’. Here we show that renal injury leads to massive cystic disease in the same mouse line. Cysts are labeled with a collecting duct/tubule marker, Lectin Dolichos biflorus Agglutinin, which correlates with the site of Cre-mediated recombination in the collecting system. 5-Bromo-2'-deoxyuridine labeling reveals that cyst-lining epithelial cells are comprised of regenerated cells in response to renal injury. These data demonstrate, for the first time, a role for polycystin-1 in kidney injury and repair and indicate that renal injury constitutes a ‘third hit’ resulting in rapid cyst formation in adulthood.

  J. Zhou and X. Huang
  In this study, the nonlinear fault detection and isolation (FDI) scheme is successfully applied to the aerocraft’s nonlinear closed-loop control system, which is established by using the dynamic inversion theory. The nonlinear FDI scheme consists of a bank of nonlinear adaptive estimators. One of them is the fault detection and approximation estimator, whereas the others are used for fault isolation (each associated with a specific type of fault). A type of fault that has occurred can be isolated if the residual associated with the matched isolation estimator remains below its corresponding adaptive threshold and at least one of the components of the residuals associated with all the other estimators exceeds its threshold at some finite time. The simulation results show the effectiveness of the application.
  Z. Zhang , S. Li and J. Zhou
  Estimate request service demand is vital for resource management and capacity planning in large web servicing system. Most existing works assume the service demand is load-independent. This study showed that it is not the case for modern processors with Dynamic Frequency Scaling (DFS) and Simultaneous Multi-Threading (SMT) capabilities. Through experiments in a Xeon processor under Linux, this study showed that the CPU demand can be modeled as a polynomial function of CPU utilization with degree 2 or 3. This study proposed a quadratic programming based optimization method to infer the polynomial coefficients from readily available CPU utilization and response time data. Comparing with widely used regression method, proposed optimization method can reduce the error by more than half in most cases. Proposed method is also more accurate than the existing load-dependent estimation method, particularly in workload of requests with different sizes.
  X Huang , X Bai , Y Cao , J Wu , M Huang , D Tang , S Tao , T Zhu , Y Liu , Y Yang , X Zhou , Y Zhao , M Wu , J Wei , D Wang , G Xu , S Wang , D Ma and J. Zhou

Angiogenesis is increasingly recognized as an important prognosticator associated with the progression of lymphoma and as an attractive target for novel modalities. We report a previously unrecognized mechanism by which lymphoma endothelium facilitates the growth and dissemination of lymphoma by interacting with circulated T cells and suppresses the activation of CD4+ T cells. Global gene expression profiles of microdissected endothelium from lymphoma and reactive lymph nodes revealed that T cell immunoglobulin and mucin domain–containing molecule 3 (Tim-3) was preferentially expressed in lymphoma-derived endothelial cells (ECs). Clinically, the level of Tim-3 in B cell lymphoma endothelium was closely correlated to both dissemination and poor prognosis. In vitro, Tim-3+ ECs modulated T cell response to lymphoma surrogate antigens by suppressing activation of CD4+ T lymphocytes through the activation of the interleukin-6–STAT3 pathway, inhibiting Th1 polarization, and providing protective immunity. In a lymphoma mouse model, Tim-3–expressing ECs promoted the onset, growth, and dissemination of lymphoma by inhibiting activation of CD4+ T cells and Th1 polarization. Our findings strongly argue that the lymphoma endothelium is not only a vessel system but also a functional barrier facilitating the establishment of lymphoma immune tolerance. These findings highlight a novel molecular mechanism that is a potential target for enhancing the efficacy of tumor immunotherapy and controlling metastatic diseases.

  J. Zhou , Z. Wang , Z.-Q. Wu , S.-J. Qiu , Y. Yu , X.-W. Huang , Z.-Y. Tang and J. Fan

Aim: Sirolimus (SRL) acts as a primary immunosuppressant or antitumor agent. The aim of the present study was to evaluate the influence of SRL on the recurrence rate and survival of patients after orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC) exceeding the Milan criteria.

Materials and Methods: We retrospectively examined 73 consecutive patients who underwent OLT for HCC exceeding the Milan criteria from March 2004 through December 2005. Among them, 27 patients were treated with SRL-based immunosuppressive protocols after OLT, and 46 patients by an FK506-based protocol. Statistical analysis was based on the intent-to-treat method.

Results: The 2 groups were comparable in all clinicopathologic parameters. The mean overall survival was 594 ± 35 days in the SRL group and 480 ± 42 days in the FK506 group (P = .011); the mean disease-free survival period was 519 ± 43 days in the SRL group and 477 ± 48 days in the FK506 group (P = .234). Multivariate analysis revealed Child`s status (P = .004) and immunosuppressive protocol (P = .015) were the significant factors affecting overall survival. Only microvascular invasion (P = .004) was significantly associated with disease-free survival. Among 24 surviving patient in the SRL group, 2 patients had SRL discontinued for toxicity; 10 had SRL monotherapy immunosuppression.

Conclusion: The SRL-based immunosuppressive protocol improved the overall survival of patients after OLT for HCC exceeding the Milan criteria, probably by postponing recurrence and with better tolerability.
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